Observational Study of the Clinico-biological Evolution and Standard of Care Offered to Patients With Ebola Virus Disease

NCT04815174 | Completed

• 1 other identifier: ALIMA01
• Study Type: observational
• Target: 711
• Locations: 1 country
• Sites: 1

Brief Summary

This study highlighted the possibility, even in epidemic settings, of providing advanced supportive care for patients with VMEs. Indeed, while the prospect of offering any invasive medical care was widely discussed in 2014 in West Africa with the aim of limiting the exposure of caregivers, the epidemic of 2018-2019 has on the contrary seen the development of a number of medical care strategies, in parallel with the deployment of specific treatments. This study aims to describe a cohort of patients receiving this upgraded supportive care during the tenth epidemic in the DRC.

Conditions

Ebola Virus Disease

Outcome Measures

Primary Outcomes (1)

• Mortality

  Any type mortality during hospitalization

  Through the end of the hospitalization, with an average of 11 days

Interventions

Standard of Care OTHER

(i) advanced clinical and biological monitoring system (ii) symptomatic treatment adapted to the patient's needs, such as antibiotic therapy, oxygen therapy and blood transfusion; (iii) dialysis or mechanical ventilation.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients with positive RT-PCR admitted in ETC's during the inclusion period were included in the study

You may qualify if:

• Laboratory confirmed Ebola Virus Disease

Sponsors & Collaborators

• Alliance for International Medical Action: lead

Study Sites (1)

BENI ETC

Beni, North Kivu, Democratic Republic of the Congo

Location

MeSH Terms

Conditions

Hemorrhagic Fever, Ebola

Interventions

Standard of Care

Condition Hierarchy (Ancestors)

Hemorrhagic Fevers, Viral; RNA Virus Infections; Virus Diseases; Infections; Filoviridae Infections; Mononegavirales Infections

Intervention Hierarchy (Ancestors)

Quality Indicators, Health Care; Quality of Health Care; Health Services Administration; Health Care Quality, Access, and Evaluation

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 17, 2021
• First Posted: March 24, 2021
• Study Start: August 1, 2018
• Primary Completion: December 31, 2019
• Study Completion: December 31, 2019
• Last Updated: March 24, 2021

Record last verified: 2021-03

Locations

DE (1)