COVID-19 and Acute Invasive Fungal Rhinosinusitis

NCT04809480 | Completed

• 1 other identifier: 20- 11- 002
• Study Type: observational
• Target: 56
• Locations: 0 countries
• Sites: N/A

Brief Summary

Data for acute invasive rhinosinusitis was obtained from the Otorhinolaryngology departments at our tertiary hospital at the period from January 2017 to December 2020. Then the risk factors of comorbid diseases and fungal types between post-Covid-19 and non-Covid-19 groups regarding the incidence of invasive rhinosinusitis are compared.

Conditions

Covid19

Keywords

fungal sinusitis; rhinosinusitis

Outcome Measures

Primary Outcomes (1)

• Fungus detection

  Culture and microscopic examination by the light microscope to examine the different types of the fungi using hematoxylin \& eosin stain and Periodic acid-Schiff stain which is positive in fungi

  2 weeks

Study Arms (2)

Non-COVID19 patients

All acute invasive fungal rhinosinusitis patients managed in our hospital from January 2017 up to February 2020

Diagnostic Test: Fungal rhinosinusitis

COVID19 patients

All acute invasive fungal rhinosinusitis patients managed in our hospital from February 2020 up to December 2020 with positive COVID19 PCR test

Diagnostic Test: Fungal rhinosinusitis

Interventions

Fungal rhinosinusitis DIAGNOSTIC_TEST

Pathology examination

COVID19 patients; Non-COVID19 patients

Eligibility Criteria

• Age: 15 Years - 90 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients of any age and sex medically managed in AlAzhar Hospitals in Egypt for invasive rhinosinusoitis

You may qualify if:

• Patients of any age and sex. invasive rhinosinusoitis diagnosis based on clinical , endoscopic diagnosis
• Positive findings for acute sinusitis on sinus computed tomography (CT) scan in addition to fungal determination by histopathological examination of specimen of affected tissues for detection of the type of fungi.
• Positive PCR was confirmed from the patient's files at the isolation hospitals for COVID 19 group.

You may not qualify if:

• Patients who completed management outside our hospital

Sponsors & Collaborators

• Al-Azhar University: lead

MeSH Terms

Conditions

COVID-19; Rhinosinusitis

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Rhinitis; Sinusitis; Paranasal Sinus Diseases; Nose Diseases; Otorhinolaryngologic Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: laboratory manager

Study Record Dates

• First Submitted: March 19, 2021
• First Posted: March 22, 2021
• Study Start: January 1, 2017
• Primary Completion: December 31, 2020
• Study Completion: December 31, 2020
• Last Updated: March 22, 2021

Record last verified: 2021-03