Correlation of the Inflammatory Parameters With Pain and Radiological Findings in Coxarthrosis

NCT04796129 | Completed

• 1 other identifier: 2020/329
• Study Type: observational
• Target: 135
• Locations: 1 country
• Sites: 1

Brief Summary

Osteoarthritis (OA) is a functional disease with joint degeneration with subchondral and periosteal lesions. Coxarthrosis (or hip osteoarthritis) is an important cause of disability, especially in the advanced age group.Although hip osteoarthritis is often thought to be a non-inflammatory pathology, recent studies have shown that joint degeneration is correlated with the production of inflammatory factors and cartilage destroying enzymes. There are very few studies evaluating the correlation of Neutrophil lymphocyte ratio, monocyte lymphocyte ratio and Platelet lymphocyte ratio with inflammatory parameters CRP and ESR levels in hip osteoarthritis and its relation with the staging of hip osteoatritis.

Conditions

Osteoarthritis, Hip; Inflammation; Pain

Keywords

hip osteoarthritis; inflammation; pain severity; pain level

Outcome Measures

Primary Outcomes (8)

• Visual Analog Scale

  pain of the hip joints of the participants. It will be evaluated by using Visual Analog Scale(VAS). The scale is a unidimensional measure of pain intensity, which has been widely used in diverse adult populations. The pain range is from 1 to 10. The minimum value is 1 and it means the pain is so mild. The maximum value is 10, it means the pain is so much, like a knife stabs.

  1 day

• NLR

  neutrophil lymphocyte ratio

  1day

• PLR

  platelet lymphocyte ratio

  1 day

• MLR

  monocyte lymphocyte ratio

  1 day

• ESR

  Erythrocyte Sedimentation Ratio

  1 day

• CRP

  C-reactive protein

  1 day

• X-ray of hip joints

  an AP X-ray for the painful hip joints

  1 day

• Lequesne Index

  pain severity

  1 day

Study Arms (2)

patients with hip osteoarthritis

the patients who aged 45 and older and have paint in the hips. and also without having any other comorbidities about inflammatory status.

Other: the patients with hip osteoarthritis and their inflammatory status

control

the participants who have any other comorbidities for impact on the inflammatory status and also no hip pain.

Other: the patients with hip osteoarthritis and their inflammatory status

Interventions

the patients with hip osteoarthritis and their inflammatory status OTHER

The participants in the experimental group will be evaluated for the hip osteoarthritis. They will take and X-ray for hip joints and also hemogram for the excluding the inflammatory diseases.

control; patients with hip osteoarthritis

Eligibility Criteria

• Age: 45 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

the participants in the experimental group are at aged 45 years or older and have hip osteoarthritis the participants in the control group are at aged 45 years or older and have no any other diseases that effect the inflammatory status

You may qualify if:

• Being diagnosed with hip osteoarthritis
• Being aged at 45 years or older

You may not qualify if:

• Not accept being participation in the study.
• Having any systemic disease like the diabetes mellitus, hypertension, coronary after disease
• Having any inflammatory rheumatologic disease
• Having any disease that prevent to participate the study like mental retardation, dementia and psychotic disorders.

Sponsors & Collaborators

• Istanbul University: lead
• Kanuni Sultan Suleyman Training and Research Hospital: collaborator
• Abant Izzet Baysal University: collaborator

Study Sites (1)

Kanuni Sultan Suleyman Training and Research Hospital

Istanbul, 34303, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Osteoarthritis, Hip; Inflammation; Pain

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Merve Damla Korkmaz, 1

  Istanbul University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle investigator

Study Record Dates

• First Submitted: February 10, 2021
• First Posted: March 12, 2021
• Study Start: February 11, 2021
• Primary Completion: November 10, 2021
• Study Completion: January 10, 2022
• Last Updated: February 21, 2022

Record last verified: 2022-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: The data will be available after publication
• Access Criteria: The data will share with permission and request.

Locations

TU (1)