Conditions

Chronic Coronary Insufficiency Non ST Elevation Myocardial Infarction

Keywords

FFRPPGPCI

Outcome Measures

Primary Outcomes (1)

Predictive capacity of the PPG index for post-PCI FFR.
Describe the relationship between pre PCI PPG and post-PCI FFR
1 year

Secondary Outcomes (2)

To assess the relationship between baseline PPG index and major adverse cardiovascular events (cardiac death, peri-procedural and spontaneous myocardial infarction and target vessel revascularization) at one, two and three years.
3 years after completion of inclusion
Difference between baseline and 12 month follow-up in the Seattle Angina Questionnaire (SAQ) stratified by PPG index.
1 years after completion of inclusion

Other Outcomes (1)

Rate of patients with intended PCI but deferred after PPG calculation.
1 year

Study Arms (1)

Stable CAD or stabilized NSTEMI (ACS) with significant epicardial lesions defined as FFR≤0.80.

The PPG Global Registry an investigator-initiated, observational, multicenter study of patients with an indication for PCI based on coronary angiography and FFR ≤0.80. After confirmation of intention to treat with PCI, a manual pullback with PPG analysis will be performed. A second level of decision making is then performed concerning PCI, coronary artery bypass grafting (CABG) or medical therapy (OMT). Patients will undergo PCI at operator discretion and post-PCI FFR will be measured. Clinical follow-up will be performed at 1, 2 and 3 years.

Eligibility Criteria

Age18 Years - 100 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Consecutive patients with stable coronary artery disease or stabilized acute coronary syndrome and indication for hemodynamic assessment by FFR and subsequent confirmation of significant epicardial CAD assessed by an invasive FFR measurement ≤0.80.

You may qualify if:

Consecutive patients with stable coronary artery disease or stabilized acute coronary syndrome and invasive FFR measurement ≤0.80.

Sponsors & Collaborators

VZW Cardiovascular Research Center Aalst
Otherlead

Study Sites (23)

Stanford University

Stanford, California, 94305, United States

St Francis Hospital and Heart Center

New York, New York, 11576, United States

Memorial Hermann Texas Medical Center

Texas City, Texas, 77030, United States

Monash Medical Center

Melbourne, Australia

Concord Repatriation General Hospital

Sydney, Australia

OLV Aalst

Aalst, Belgium

Aalborg University Hospital

Aalborg, Denmark

Related Publications (5)

Collet C, Sonck J, Vandeloo B, Mizukami T, Roosens B, Lochy S, Argacha JF, Schoors D, Colaiori I, Di Gioia G, Kodeboina M, Suzuki H, Van 't Veer M, Bartunek J, Barbato E, Cosyns B, De Bruyne B. Measurement of Hyperemic Pullback Pressure Gradients to Characterize Patterns of Coronary Atherosclerosis. J Am Coll Cardiol. 2019 Oct 8;74(14):1772-1784. doi: 10.1016/j.jacc.2019.07.072.
PMID: 31582137BACKGROUND
Hada M, Mizukami T, Ikeda K, Munhoz D, Brouwers S, Sonck J, Matsuo H, Shinke T, Ando H, Ko B, Biscaglia S, Rivero F, Engstrom T, Arslani K, Leone AM, Galante D, van Nunen LX, Fearon WF, Christiansen EH, Fournier S, Desta L, Yong A, Adjedj J, Escaned J, Nakayama M, Eftekhari A, Zimmermann FM, Sakai K, Storozhenko T, da Costa BR, Campo G, Berry C, Collison D, Johnson T, Amano T, Perera D, Jeremias A, Ali Z, De Bruyne B, Barbato P, Corradetti S, Stalikas N, Kechichian A, Bouisset F, Kakuta T, Johnson NP, Collet C. Impact of Sex on Residual Angina After Percutaneous Coronary Interventions. Catheter Cardiovasc Interv. 2026 Mar;107(4):987-996. doi: 10.1002/ccd.70419. Epub 2025 Dec 17.
PMID: 41408672

MeSH Terms

Conditions

Non-ST Elevated Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial InfarctionMyocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosis

Study Officials

Carlos Collet, MD PhD
OLV Hospital
PRINCIPAL INVESTIGATOR

Pullback Pressure Gradient (PPG) Global Registry

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Other Outcomes (1)

Study Arms (1)

Stable CAD or stabilized NSTEMI (ACS) with significant epicardial lesions defined as FFR≤0.80.

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (23)

Related Publications (5)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Other Outcomes (1)

Study Arms (1)

Stable CAD or stabilized NSTEMI (ACS) with significant epicardial lesions defined as FFR≤0.80.

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (23)

Related Publications (5)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations