TMS-based Assessment of Mental Training Effects on Motor Learning in Healthy Participants

NCT04784832 | Recruiting

• 2 other identifiers: C19-192020-A00305-34 / 1
• Study Type: interventional
• Target: 556
• Locations: 1 country
• Sites: 1

Brief Summary

The general purpose of this research project is to analyze the specific role of motor imagery on motor learning, assessed through corticospinal excitability measurements and behavioral data collection. This project is based on four sequences. For Sequence 1, the main objective is to examine the effect of mental training on movement speed and accuracy in a manual motor sequence task, as well as the influence of sensory feedback in immediate post-test (i.e., execution of a similar, but not identical, manual motor sequence, other manual tasks) on performance in delayed post-test. The secondary objective will be to examine corticospinal changes (i.e., amplitude of motor evoked potentials) induced by mental training, by measuring the amplitude of motor evoked potentials before and after mental training. For Sequence 2, the main objective is to examine the impact of a motor disturbance induced by a robotic arm at different intervals during the motor imagery process. The secondary objective will be to examine the corticospinal changes (i.e. amplitude of evoked motor potentials) induced by mental training as a function of the applied perturbations, before and after perturbation. For Sequence 3, the main objective will be to examine the influence of neuroplasticity on the quality of mental training. More specifically, the investigators will study the links between brain plasticity and motor learning through mental training. The secondary objective will be to examine the corticospinal changes (i.e. amplitude of evoked motor potentials) induced by mental training at different levels of the neuromuscular system (cortical, cervicomedullar, peripheral) after a training period. For Sequence 4, the main objective will be to examine the effect of short-term arm-immobilization of on the retention of motor learning induced by mental training. The secondary objective will be to examine the corticospinal changes (i.e., amplitude of motor evoked potentials) induced by of short-term arm-immobilization, or by transcranial direct current stimulation (tDCS), on motor learning. The results of this fundamental research project will allow a better understanding of neurophysiological and behavioral mechanisms that underlie motor learning through motor imagery. The results will allow to efficiently consider inter-individual specificities and will thus open up to clinical research perspectives, towards the establishment of adapted motor rehabilitation protocols.

Conditions

Motor Learning

Outcome Measures

Primary Outcomes (9)

• Evolution of movement speed - Sequence 1

  The duration of performed movement sequences

  Each day in Sequence 1 (Sequence 1 is 11 days)

• Evolution of movement accuracy - Sequence 1

  The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence).

  Each day in Sequence 1 (Sequence 1 is 11 days)

• Evolution of trajectory error - Sequence 2

  The area under the curve of hand's trajectory according to the straight line joining the starting target and the final target.

  Each day in Sequence 2 (Sequence 1 is 10 days)

• Evolution of maximal deviation - Sequence 2

  The maximal perpendicular distance between the position of the hand and the straight line joining the starting target and the final target

  Each day in Sequence 2 (Sequence 1 is 10 days)

• Evolution of final error - Sequence 2

  The distance between the final position of the hand and the position of the final target.

  Each day in Sequence 2 (Sequence 1 is 10 days)

• Evolution of movement speed - Sequence 3

  The duration of performed movement sequences

  Each day from day 2 to day 11 of Sequence 3 (Sequence 3 is 11 days)

• Evolution of movement accuracy - Sequence 3

  The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence).

  Each day from day 2 to day 11 of Sequence 3 (Sequence 3 is 11 days)

• Evolution of movement speed - Sequence 4

  The duration of performed movement sequences

  Each day in Sequence 4 (Sequence 4 is 6 days)

• Evolution of movement accuracy - Sequence 4

  The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence).

  Each day in Sequence 4 (Sequence 4 is 6 days)

Secondary Outcomes (4)

• Evolution of motor evoked potentials amplitude - Sequence 1

  Day 1, 5, 6, 10 and 11 in Sequence 1 (Sequence 1 is 11 days).

• Evolution of motor evoked potentials amplitude - Sequence 2

  Each day in Sequence 2 (Sequence 2 is 10 days)

• Evolution of motor evoked potentials amplitude - Sequence 3

  Day 1, 5, 6, 10 and 11 in Sequence 3 (Sequence 1 is 11 days)

• Evolution of motor evoked potentials amplitude - Sequence 4

  Days 1, 5, and 6 in Sequence 4 (Sequence 4 is 6 days)

Study Arms (28)

Sequence 1 - Training with same task - Long follow-up

EXPERIMENTAL

Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training

Device: Transcranial magnetic stimulation; Other: Mental training

Sequence 1 - Training with same task - Short follow-up

EXPERIMENTAL

Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training

Device: Transcranial magnetic stimulation; Other: Mental training

Sequence 1 - Training with different tasks - Long follow-up

EXPERIMENTAL

Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training

Device: Transcranial magnetic stimulation; Other: Mental training

Sequence 1 - Training with different tasks - Short follow-up

EXPERIMENTAL

Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training

Device: Transcranial magnetic stimulation; Other: Mental training

Sequence 1 - Training with muscle contractions - Long follow-up

EXPERIMENTAL

Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training

Device: Transcranial magnetic stimulation; Other: Mental training

Sequence 1 - Training with muscle contractions - Short follow-up

EXPERIMENTAL

Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training

Device: Transcranial magnetic stimulation; Other: Mental training

Sequence 1 - Control

ACTIVE COMPARATOR

Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation No mental training

Device: Transcranial magnetic stimulation

Sequence 2 - Physical training with perturbation during preparation - Long follow-up

ACTIVE COMPARATOR

Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training

Device: Transcranial magnetic stimulation; Device: Robotic arm; Other: Physical training

Sequence 2 - Physical training with perturbation during preparation - Short follow-up

ACTIVE COMPARATOR

Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training

Device: Transcranial magnetic stimulation; Device: Robotic arm; Other: Physical training

Sequence 2 - Physical training with perturbation after preparation - Long follow-up

ACTIVE COMPARATOR

Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training

Device: Transcranial magnetic stimulation; Device: Robotic arm; Other: Physical training

Sequence 2 - Physical training with perturbation after preparation - Short follow-up

ACTIVE COMPARATOR

Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training

Device: Transcranial magnetic stimulation; Device: Robotic arm; Other: Physical training

Sequence 2 - Mental training with perturbation during preparation - Long follow-up

EXPERIMENTAL

Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training

Device: Transcranial magnetic stimulation; Device: Robotic arm; Other: Mental training

Sequence 2 - Mental training with perturbation during preparation - Short follow-up

EXPERIMENTAL

Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training

Device: Transcranial magnetic stimulation; Device: Robotic arm; Other: Mental training

Sequence 2 - Mental training with perturbation after preparation - Long follow-up

EXPERIMENTAL

Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training

Device: Transcranial magnetic stimulation; Device: Robotic arm; Other: Mental training

Sequence 2 - Mental training with perturbation after preparation - Short follow-up

EXPERIMENTAL

Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training

Device: Transcranial magnetic stimulation; Device: Robotic arm; Other: Mental training

Sequence 3 - Training (same task) - Long follow-up

EXPERIMENTAL

Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation

Device: Transcranial magnetic stimulation; Device: Peripheral Nerve Stimulation; Device: Paired Associative Stimulation; Device: Cervicomedullar stimulation; Other: Mental training

Sequence 3 - Training (same task) - Short follow-up

EXPERIMENTAL

Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation

Device: Transcranial magnetic stimulation; Device: Peripheral Nerve Stimulation; Device: Paired Associative Stimulation; Device: Cervicomedullar stimulation; Other: Mental training

Sequence 3 - Training (different task) - Long follow-up

EXPERIMENTAL

Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation

Device: Transcranial magnetic stimulation; Device: Peripheral Nerve Stimulation; Device: Paired Associative Stimulation; Device: Cervicomedullar stimulation; Other: Mental training

Sequence 3 - Training (different task) - Short follow-up

EXPERIMENTAL

Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation

Device: Transcranial magnetic stimulation; Device: Peripheral Nerve Stimulation; Device: Paired Associative Stimulation; Device: Cervicomedullar stimulation; Other: Mental training

Sequence 3 - Control 1

ACTIVE COMPARATOR

Mental Training Motor task (same as the motor task) Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation

Device: Transcranial magnetic stimulation; Device: Peripheral Nerve Stimulation; Device: Cervicomedullar stimulation; Other: Mental training

Sequence 3 - Control 2

ACTIVE COMPARATOR

Paired Associative Stimulation Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation

Device: Transcranial magnetic stimulation; Device: Peripheral Nerve Stimulation; Device: Paired Associative Stimulation; Device: Cervicomedullar stimulation

Sequence 4 - Immobilization - Short follow-up

EXPERIMENTAL

Transcranial magnetic stimulation Arm immobilization Motor task Mental training

Device: Transcranial magnetic stimulation; Device: Wrist; Other: Mental training

Sequence 4 - Immobilization - Long follow-up

EXPERIMENTAL

Transcranial magnetic stimulation Arm immobilization Motor task Mental training

Device: Transcranial magnetic stimulation; Device: Wrist; Other: Mental training

Sequence 4 - Cathodal - Short follow-up

EXPERIMENTAL

Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training

Device: Transcranial magnetic stimulation; Device: Transcranial direct current stimulation; Other: Mental training

Sequence 4 - Cathodal - Long follow-up

EXPERIMENTAL

Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training

Device: Transcranial magnetic stimulation; Device: Transcranial direct current stimulation; Other: Mental training

Sequence 4 - Anodal - Short follow-up

EXPERIMENTAL

Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training

Device: Transcranial magnetic stimulation; Device: Transcranial direct current stimulation; Other: Mental training

Sequence 4 - Anodal - Long follow-up

EXPERIMENTAL

Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training

Device: Transcranial magnetic stimulation; Device: Transcranial direct current stimulation; Other: Mental training

Sequence 4 - Control

SHAM COMPARATOR

Transcranial magnetic stimulation Motor task Mental training

Device: Transcranial magnetic stimulation; Other: Mental training

Interventions

Transcranial magnetic stimulation DEVICE

Magnetic stimulation of the cortex

Also known as: TMS

Sequence 1 - Control; Sequence 1 - Training with different tasks - Long follow-up; Sequence 1 - Training with different tasks - Short follow-up; Sequence 1 - Training with muscle contractions - Long follow-up; Sequence 1 - Training with muscle contractions - Short follow-up; Sequence 1 - Training with same task - Long follow-up; Sequence 1 - Training with same task - Short follow-up; Sequence 2 - Mental training with perturbation after preparation - Long follow-up; Sequence 2 - Mental training with perturbation after preparation - Short follow-up; Sequence 2 - Mental training with perturbation during preparation - Long follow-up; Sequence 2 - Mental training with perturbation during preparation - Short follow-up; Sequence 2 - Physical training with perturbation after preparation - Long follow-up; Sequence 2 - Physical training with perturbation after preparation - Short follow-up; Sequence 2 - Physical training with perturbation during preparation - Long follow-up; Sequence 2 - Physical training with perturbation during preparation - Short follow-up; Sequence 3 - Control 1; Sequence 3 - Control 2; Sequence 3 - Training (different task) - Long follow-up; Sequence 3 - Training (different task) - Short follow-up; Sequence 3 - Training (same task) - Long follow-up; Sequence 3 - Training (same task) - Short follow-up; Sequence 4 - Anodal - Long follow-up; Sequence 4 - Anodal - Short follow-up; Sequence 4 - Cathodal - Long follow-up; Sequence 4 - Cathodal - Short follow-up; Sequence 4 - Control; Sequence 4 - Immobilization - Long follow-up; Sequence 4 - Immobilization - Short follow-up

Peripheral Nerve Stimulation DEVICE

Electric stimulation of the nerves

Sequence 3 - Control 1; Sequence 3 - Control 2; Sequence 3 - Training (different task) - Long follow-up; Sequence 3 - Training (different task) - Short follow-up; Sequence 3 - Training (same task) - Long follow-up; Sequence 3 - Training (same task) - Short follow-up

Transcranial direct current stimulation DEVICE

Electric stimulation of the cortex

Also known as: tDCS

Sequence 4 - Anodal - Long follow-up; Sequence 4 - Anodal - Short follow-up; Sequence 4 - Cathodal - Long follow-up; Sequence 4 - Cathodal - Short follow-up

Paired Associative Stimulation DEVICE

Combined magnetic and electric stimulation of cortex and nerve, respectively

Also known as: PAS

Sequence 3 - Control 2; Sequence 3 - Training (different task) - Long follow-up; Sequence 3 - Training (different task) - Short follow-up; Sequence 3 - Training (same task) - Long follow-up; Sequence 3 - Training (same task) - Short follow-up

Wrist DEVICE

Short-term immobilization of the arm

Sequence 4 - Immobilization - Long follow-up; Sequence 4 - Immobilization - Short follow-up

Robotic arm DEVICE

External perturbation of force field induced by robotic arm

Sequence 2 - Mental training with perturbation after preparation - Long follow-up; Sequence 2 - Mental training with perturbation after preparation - Short follow-up; Sequence 2 - Mental training with perturbation during preparation - Long follow-up; Sequence 2 - Mental training with perturbation during preparation - Short follow-up; Sequence 2 - Physical training with perturbation after preparation - Long follow-up; Sequence 2 - Physical training with perturbation after preparation - Short follow-up; Sequence 2 - Physical training with perturbation during preparation - Long follow-up; Sequence 2 - Physical training with perturbation during preparation - Short follow-up

Cervicomedullar stimulation DEVICE

Electric stimulation of the muscle

Sequence 3 - Control 1; Sequence 3 - Control 2; Sequence 3 - Training (different task) - Long follow-up; Sequence 3 - Training (different task) - Short follow-up; Sequence 3 - Training (same task) - Long follow-up; Sequence 3 - Training (same task) - Short follow-up

Physical training OTHER

Training to perform the task by actually doing the task

Sequence 2 - Physical training with perturbation after preparation - Long follow-up; Sequence 2 - Physical training with perturbation after preparation - Short follow-up; Sequence 2 - Physical training with perturbation during preparation - Long follow-up; Sequence 2 - Physical training with perturbation during preparation - Short follow-up

Mental training OTHER

Training to perform the task by imaging doing the task

Sequence 1 - Training with different tasks - Long follow-up; Sequence 1 - Training with different tasks - Short follow-up; Sequence 1 - Training with muscle contractions - Long follow-up; Sequence 1 - Training with muscle contractions - Short follow-up; Sequence 1 - Training with same task - Long follow-up; Sequence 1 - Training with same task - Short follow-up; Sequence 2 - Mental training with perturbation after preparation - Long follow-up; Sequence 2 - Mental training with perturbation after preparation - Short follow-up; Sequence 2 - Mental training with perturbation during preparation - Long follow-up; Sequence 2 - Mental training with perturbation during preparation - Short follow-up; Sequence 3 - Control 1; Sequence 3 - Training (different task) - Long follow-up; Sequence 3 - Training (different task) - Short follow-up; Sequence 3 - Training (same task) - Long follow-up; Sequence 3 - Training (same task) - Short follow-up; Sequence 4 - Anodal - Long follow-up; Sequence 4 - Anodal - Short follow-up; Sequence 4 - Cathodal - Long follow-up; Sequence 4 - Cathodal - Short follow-up; Sequence 4 - Control; Sequence 4 - Immobilization - Long follow-up; Sequence 4 - Immobilization - Short follow-up

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male or female between 18 and 60 years old
• Having given written informed consent
• Affiliated to a social security scheme

You may not qualify if:

• History of psychiatric illness (declarative)
• Person under guardianship, curatorship, safeguard of justice
• Neurological problem that could bias the results of the study (declarative)
• Personal or family history of epilepsy
• Person deprived of liberty by judicial or administrative decision
• Person hospitalized without consent and not subject to legal protection, and person admitted to a health or social institution for purposes other than that of the research
• Pregnant women or women of childbearing age not using known contraception
• Breastfeeding women
• Person on medication that could influence neurophysiological measures (neuroleptics, anxiolytics, antidepressants)
• Person carrying :
• pacemaker or other device that could interfere with the magnetic field
• Implants (mechanical or electronic: cochlear implants, neural or cardiac pacemakers, infusion pumps, magnetic aneurysm clips, etc.)
• Metallic foreign bodies in the eye or nervous system
• Metallic objects (tattoos, piercings, etc.)

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France: lead

Study Sites (1)

INSERM - U1093 Cognition, Action, and Sensorimotor Plasticity

Dijon, France

RECRUITING

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MeSH Terms

Interventions

Transcranial Magnetic Stimulation; Transcranial Direct Current Stimulation; Physical Conditioning, Human

Intervention Hierarchy (Ancestors)

Magnetic Field Therapy; Therapeutics; Electric Stimulation Therapy; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Florent Lebon, PhD

  Institut National de la Santé Et de la Recherche Médicale, France

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Florent Lebon, PhD

CONTACT

+33 3 80 39 67 49; florent.lebon@u-bourgogne.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 7, 2020
• First Posted: March 5, 2021
• Study Start: April 8, 2024
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): April 1, 2029
• Last Updated: April 20, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)