NCT04773613

Brief Summary

One of the challenges of modern neonatology is to identify the right and effective method that can improve oral feeding. Optimal feeding position may contribute to improving the quality and safety of bottle-feeding in premature infants.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
42

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jul 2018

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 19, 2018

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 20, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 20, 2020

Completed
10 months until next milestone

First Submitted

Initial submission to the registry

January 30, 2021

Completed
27 days until next milestone

First Posted

Study publicly available on registry

February 26, 2021

Completed
Last Updated

September 24, 2021

Status Verified

February 1, 2021

Enrollment Period

1.8 years

First QC Date

January 30, 2021

Last Update Submit

September 18, 2021

Conditions

Keywords

Premature InfantBottle FeedingSide-lying PositionSemi-elevated PositionOral Feeding

Outcome Measures

Primary Outcomes (8)

  • Physiological stability

    Oxygen saturation (SpO2) changes measured by using a pulse oximeter data

    Measured 2 minutes before feeding session, in 3rd and 10th minutes of feeding, at the moment of finish of the feeding and in 10th minute after feeding (5 points of measurement)

  • Physiological stability

    Heart rate (HR) changes measured by using a pulse oximeter data

    Measured 2 minutes before feeding session, in 3rd and 10th minutes of feeding, at the moment of finish of the feeding and in 10th minute after feeding (5 points of measurement)

  • Qualitative aspect of bottle-feeding

    Total time of declines of SpO2 ≤85%

    Measured during feeding

  • Qualitative aspect of bottle-feeding

    Level of the newborn's alertness changes according to the 6-point Neonatal Behavioral Assessment Scale, where individual points mean: 1 - quiet sleep, 2 - active sleep, 3 - drowsy, 4 - quiet alert, 5 - active alert, 6 - crying. This is descriptive, qualitative scale which shows changes of newborn's activity.

    Measured 2 minutes before feeding session, in 3rd and 10th minutes of feeding, at the moment of finish of the feeding and in 10th minute after feeding (5 points of measurement)

  • Qualitative aspect of bottle-feeding

    Occurrence of choking episodes

    Noticed during feeding

  • Qualitative aspect of bottle-feeding

    Duration of the feeding session

    Measured from taking the baby out of bed before feeding to putting the baby to bed immediately after the intervention. Putting baby on parent's chest to kangaroo (Kangaroo Mother Care) after feeding instead to bed was also allowed.

  • Qualitative aspect of bottle-feeding

    Duration of feeding

    Measured from insertion of the nipple to the infant's mouth to the moment when baby finish the feeding

  • Qualitative aspect of bottle-feeding

    Proportion of milk consumed (volume of milk eaten relative to the expected volume)

    Measured in 10th minute of feeding and on the finish of the feeding (2 points of measurement)

Study Arms (2)

Experimental SLP

EXPERIMENTAL

Infant placed in a SLP on the researcher's lap. Head of the infant symmetrically placed between the shoulders, supported by the researcher's. Shoulder girdle higher than the pelvic girdle, head and back in a straight line - a slight natural bend of the body is allowed. Legs bent at an angle of approx. 90° in the natural flexion of the knee and ankle joint. The infant's arms close to the midline (on the bottle or researcher's hands)

Other: Experimental SLP

Experimental SEP

OTHER

Infant placed in a SEP on the researcher's lap. The head rests on the researcher's hand. Shoulder girdle higher than the pelvic girdle, head and back in a straight line at an angle of 30-45° to the ground - slight, natural body bend is allowed. Legs bent at an angle of approx. 90° in the natural flexion of the knee and ankle joint. The infant's arms close to the midline (on the bottle or researcher's hands)

Other: Experimental SEP

Interventions

SLP was given to the infant during bottle-feeding.

Experimental SLP

SEP was given to the infant during bottle-feeding.

Experimental SEP

Eligibility Criteria

Age32 Weeks+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • circulatory and respiratory stability;
  • readiness for oral feeding according to each child's Speech-Language Pathologist assessment;
  • prematurely born infants who were in the process of being transferred from enteral nutrition (or enteral nutrition + parenteral nutrition) to full oral feeding and were fed orally at least 4- 6 times within twenty-four hours;
  • parents gave informed consent to participate their infant in the study.

You may not qualify if:

  • disorders which could significantly affect the feeding course, such as cleft lip and/or palate, facial paralysis and/or congenital defects of the facial skeleton;
  • the presence of detected congenital abnormalities and metabolic diseases; low Apgar score (less than 5 points at the 5th and 10th minute of the measurement);
  • administered analgesics, anticonvulsants and sedatives;
  • \<72 hours from extubation prior the trial;
  • parents refusal to participate in the study or when bottle-feeding was not the parental preference.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Polish Mother's Memorial Hospital- Research Institute

Lodz, 93-338, Poland

Location

MeSH Terms

Conditions

Bottle FeedingPremature Birth

Condition Hierarchy (Ancestors)

Feeding BehaviorBehaviorObstetric Labor, PrematureObstetric Labor ComplicationsPregnancy ComplicationsFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital Diseases

Study Officials

  • Anna D Raczyńska, MSc

    Polish Mother's Memorial Hospital- Research Institute

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

January 30, 2021

First Posted

February 26, 2021

Study Start

July 19, 2018

Primary Completion

April 20, 2020

Study Completion

April 20, 2020

Last Updated

September 24, 2021

Record last verified: 2021-02

Data Sharing

IPD Sharing
Will not share

Locations