NCT04283682

Brief Summary

Skin-to-skin combined with breastfeeding shortened the cycle of full-oral feeding in premature infants

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
148

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Apr 2020

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 18, 2020

Completed
7 days until next milestone

First Posted

Study publicly available on registry

February 25, 2020

Completed
1 month until next milestone

Study Start

First participant enrolled

April 8, 2020

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2022

Completed
29 days until next milestone

Study Completion

Last participant's last visit for all outcomes

May 30, 2022

Completed
Last Updated

December 8, 2022

Status Verified

December 1, 2022

Enrollment Period

2.1 years

First QC Date

February 18, 2020

Last Update Submit

December 6, 2022

Conditions

Keywords

Skin Contactbresatfeedingprematureoral feeding

Outcome Measures

Primary Outcomes (1)

  • Transition time from the initiation oral feeding to full oral feeding

    Transition time was defined as the days needed from introduction of oral feeding to obtain autonomous oral feeding when the nasogastric tube was removed and all the daily milk volume was taken from the bottle.

    During the procedure

Secondary Outcomes (1)

  • Exclusive breastfeeding at discharge

    During the hospitalization, an average of 2 to 3 months

Study Arms (2)

standard group

NO INTERVENTION

Feeding procedures follow clinical nursing practices

intervention group

EXPERIMENTAL

At appropriate time to invite mothers of premature infants into the NICU for skin-to-skin and breastfeeding

Behavioral: Early skin-to-skin combined with breast-feeding

Interventions

Premature infants in the intervention group have access to skin-to-skin once a day for 1 hour at least once no ventilation support needed. During the skin-to-skin period,the breastfeeding is encouraged for about 5-10 minutes. The whole intervention stop until the baby achieve the full oral feeding.

intervention group

Eligibility Criteria

AgeUp to 72 Hours
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • gestational age ≤30 weeks
  • birth weight \< 1500g
  • age of admission \<72 hours
  • no congenital malformation

You may not qualify if:

  • OI \> 40
  • mother has trouble in communicating

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Children's Hospital of Fudan University

Shanghai, China

Location

Related Publications (1)

  • Li L, Wang L, Niu C, Liu C, Lv T, Ji F, Yu L, Yan W, Dou YL, Wang Y, Cao Y, Huang G, Hu X. Early skin contact combined with mother's breastfeeding to shorten the process of premature infants </= 30 weeks of gestation to achieve full oral feeding: the study protocol of a randomized controlled trial. Trials. 2021 Sep 17;22(1):637. doi: 10.1186/s13063-021-05605-x.

MeSH Terms

Conditions

Premature Birth

Interventions

Lactation

Condition Hierarchy (Ancestors)

Obstetric Labor, PrematureObstetric Labor ComplicationsPregnancy ComplicationsFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital Diseases

Intervention Hierarchy (Ancestors)

Reproductive Physiological PhenomenaReproductive and Urinary Physiological PhenomenaPostpartum Period

Study Officials

  • ling li Li

    Wanyuan Road 399,Minhang District, Shanghai,China

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 18, 2020

First Posted

February 25, 2020

Study Start

April 8, 2020

Primary Completion

May 1, 2022

Study Completion

May 30, 2022

Last Updated

December 8, 2022

Record last verified: 2022-12

Locations