Quorn in Community Health Experiment
QUICHE
1 other identifier
interventional
82
1 country
1
Brief Summary
In overweight individuals (BMI \> 27.5 kg/m2), does daily consumption of mycoprotein containing Quorn Food products lower blood cholesterol compared with daily meat/fish consumption?
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Nov 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 9, 2020
CompletedFirst Submitted
Initial submission to the registry
February 22, 2021
CompletedFirst Posted
Study publicly available on registry
February 26, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 17, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
December 17, 2021
CompletedMarch 22, 2023
March 1, 2023
1.1 years
February 22, 2021
March 21, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
Postabsorptive blood cholesterol (free, total, LDL, HDL) concentrations
Test for intervention vs control differences in postabsorptive blood cholesterol levels (mMol) pre and post intervention
4 weeks
Secondary Outcomes (7)
Postprandial blood cholesterol concentration
3 hours
Fingerprick blood glucose concentration
4 weeks
Satiety
4 weeks
Hedonic visual analogue scale
4 weeks
Gastrointestinal side-effects
Once weekly, over 4 weeks
- +2 more secondary outcomes
Study Arms (2)
Quorn Food products
ACTIVE COMPARATORMeat/fish products
ACTIVE COMPARATORInterventions
180 g mycoprotein (wet weight; corresponding to 45 g dry weight) per day (equates to approx. 215 g Quorn Foods products, depending on the product)
Standard meat/fish products matched to Quorn group for protein intake
Eligibility Criteria
You may qualify if:
- years old
- BMI \>27.5 kg/m2
- Non allergic to penicillin/mycoprotein
- Moderate levels of physical activity or below (self-identified; NDNS servey)
- Omnivores
- Not currently using cholesterol lowering medication
You may not qualify if:
- \<18 or \>70 years old
- BMI \<27.5 kg/m2
- Allergies to penicillin/mycoprotein
- Heavy exercisers (self idenfiied)
- Vegetarian/vegans
- Currently using cholesterol lowering medication
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Exeterlead
- Marlow Foods Ltdcollaborator
- NIHR Exeter Clinical Research Facilitycollaborator
Study Sites (1)
University of Exeter
Exeter, Devon, EX1 2LU, United Kingdom
Related Publications (1)
Pavis GF, Iniesta RR, Roper H, Theobald HE, Derbyshire EJ, Finnigan TJA, Stephens FB, Wall BT. A four-week dietary intervention with mycoprotein-containing food products reduces serum cholesterol concentrations in community-dwelling, overweight adults: A randomised controlled trial. Clin Nutr. 2024 Mar;43(3):649-659. doi: 10.1016/j.clnu.2024.01.023. Epub 2024 Jan 24.
PMID: 38306892DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Benjamin T Wall, PhD
University of Exeter
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 22, 2021
First Posted
February 26, 2021
Study Start
November 9, 2020
Primary Completion
December 17, 2021
Study Completion
December 17, 2021
Last Updated
March 22, 2023
Record last verified: 2023-03