Eccentric Cycling Exercise on Hemodynamic and Hemorheologic Properties
Effects of Eccentric and Concentric Cycling Exercise Regimens on Hemodynamic and Hemorheologic Properties in Sedentary Male
1 other identifier
interventional
60
1 country
1
Brief Summary
The effects of an eccentric endurance training on central and peripheral hemodynamic adaptations and erythrocyte rheology during maximal exercise remained to be unexplored. The current study examined the contribution of rheological functions and/or hemodynamic adaptation to changes in oxygen consumption (VO2) following the matched-power output eccentric (ECT) or concentric cycling training (CCT). Method: A total of 39 sedentary males were randomly assigned into either CCT (n=13) or ECT (n=13) for 30 min a day, 5 days a week for 6 weeks at 60% of maximal workload or to a CTL (control group, n = 13). A graded exercise test (GXT) was performed before and after the intervention. Central and microvascular adaptations were evaluated using thoracic impedance and near-infrared spectroscopy (NIRS), respectively. Rheological characteristics was determined by an ektacytometer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Nov 2019
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 11, 2019
CompletedFirst Submitted
Initial submission to the registry
February 25, 2021
CompletedFirst Posted
Study publicly available on registry
February 26, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 16, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
May 16, 2022
CompletedMay 10, 2021
May 1, 2021
2.5 years
February 25, 2021
May 6, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Central and peripheral hemodynamics
Evaluate cardiac and peripheral hemodynamic response to exercise by using noninvasive continuous cardiac output monitoring system and near-infrared spectroscopy (NIRS).
12 weeks
Secondary Outcomes (2)
Cardiopulmonary fitness
12 weeks
Erythrocyte rheological characteristics
12 weeks
Study Arms (3)
Eccentric cycling training
EXPERIMENTALModerate intensity cycling training in eccentric type
Concentric cycling training
EXPERIMENTALModerate intensity cycling training in concentric type (intensity matched the eccentric training)
Control group
NO INTERVENTIONwithout receiving any exercise training
Interventions
1. Performed exercise training 5 days a week for 6 weeks on an eccentric ergometer. 2. Each training session: 3 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase. 3. Intensity: Firstly, set at 45% Wmax, and progressively increased 5% per week
1. Performed exercise training 5 days a week for 6 weeks on an eccentric ergometer. 2. Each training session: 3 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase. 3. Intensity: Firstly, set at 45% Wmax, and progressively increased 5% per week
Eligibility Criteria
You may qualify if:
- in sedentary lifestyle, who were nonsmokers, nonusers of medications/vitamins, and free of any cardiopulmonary/hematological risks
You may not qualify if:
- regular exercise habits (i.e., exercise frequency once per week, duration \>20 min).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Chang Gung University
Taoyuan District, 333, Taiwan
Related Publications (4)
Hoppeler H. Moderate Load Eccentric Exercise; A Distinct Novel Training Modality. Front Physiol. 2016 Nov 16;7:483. doi: 10.3389/fphys.2016.00483. eCollection 2016.
PMID: 27899894BACKGROUNDHaynes A, Linden MD, Chasland LC, Nosaka K, Maiorana A, Dawson EA, Dembo LH, Naylor LH, Green DJ. Acute impact of conventional and eccentric cycling on platelet and vascular function in patients with chronic heart failure. J Appl Physiol (1985). 2017 Jun 1;122(6):1418-1424. doi: 10.1152/japplphysiol.01057.2016. Epub 2017 Mar 16.
PMID: 28302709BACKGROUNDLindstedt SL, LaStayo PC, Reich TE. When active muscles lengthen: properties and consequences of eccentric contractions. News Physiol Sci. 2001 Dec;16:256-61. doi: 10.1152/physiologyonline.2001.16.6.256. No abstract available.
PMID: 11719600BACKGROUNDLaStayo PC, Ewy GA, Pierotti DD, Johns RK, Lindstedt S. The positive effects of negative work: increased muscle strength and decreased fall risk in a frail elderly population. J Gerontol A Biol Sci Med Sci. 2003 May;58(5):M419-24. doi: 10.1093/gerona/58.5.m419.
PMID: 12730250RESULT
Study Officials
- PRINCIPAL INVESTIGATOR
Jong-Shyan Wang, PhD
Chang Gung Memorial Hospital
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Consultant
Study Record Dates
First Submitted
February 25, 2021
First Posted
February 26, 2021
Study Start
November 11, 2019
Primary Completion
May 16, 2022
Study Completion
May 16, 2022
Last Updated
May 10, 2021
Record last verified: 2021-05
Data Sharing
- IPD Sharing
- Will not share