Transcranial Magnetic Stimulation in Mild Cognitive Impairment and Alzheimer Disease
1 other identifier
observational
73
0 countries
N/A
Brief Summary
The investigators reviewed 12 years of clinical use in an outpatient neurology setting of transcranial magnetic stimulation (TMS) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) to evaluate safety and efficacy of TMS.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started May 2008
Longer than P75 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 30, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
May 30, 2020
CompletedFirst Submitted
Initial submission to the registry
February 7, 2021
CompletedFirst Posted
Study publicly available on registry
February 25, 2021
CompletedFebruary 25, 2021
February 1, 2021
12.1 years
February 7, 2021
February 22, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (15)
Controlled Oral Word Association Test
Animal score and percentile
05/01/2008-05/30/2020
Boston 30-item naming test
spontaneous correct (without cues)
05/01/2008-05/30/2020
Boston 30-item naming test
total correct (with cues)
05/01/2008-05/30/2020
Wechsler Adult Intelligence Scale III
Digit span
05/01/2008-05/30/2020
Wechsler Adult Intelligence Scale III
verbal quotient score and percentile
05/01/2008-05/30/2020
Wechsler Adult Intelligence Scale III
performance quotient score and percentile
05/01/2008-05/30/2020
Wechsler Adult Intelligence Scale III
object assembly
05/01/2008-05/30/2020
Wechsler Memory Scale III
Immediate memory score and percentile
05/01/2008-05/30/2020
Wechsler Memory Scale III
Auditory delayed memory score and percentile
05/01/2008-05/30/2020
Wechsler Memory Scale III
Visual delayed memory score and percentile
05/01/2008-05/30/2020
Buschke Selective Reminding Test, 12 item
Total recall score
05/01/2008-05/30/2020
Buschke Selective Reminding Test, 12 item, 15 minute
Delayed recall score
05/01/2008-05/30/2020
Rosen Drawing Test
Total score
05/01/2008-05/30/2020
Processing speed
Total score and percentile
05/01/2008-05/30/2020
Mini-mental status examination
Total score
05/01/2008-05/30/2020
Study Arms (3)
EEG-grid-guided-TMS
Patients with Alzheimer disease and mild cognitive impairment receiving TMS using electroencephalogram grid guided navigation
MRI-guided-TMS
Patients with Alzheimer disease and mild cognitive impairment receiving TMS using MRI guided navigation
NACC controls
National Alzheimer's Coordinating Center matched controls
Interventions
Magnetic stimulation to alter neural activity
Eligibility Criteria
Patients with Alzheimer disease or mild cognitive impairment.
You may qualify if:
- Patients meeting the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS- ADRDA) criteria for possible or probable Alzheimer's disease.
- Patients meeting the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS- ADRDA) criteria for mild cognitive impairment.
- Patients must have undergone at least two standardized neurocognitive batteries before and after beginning TMS.
- Patients must have received greater than or equal to five (5) TMS sessions in less than one year.
You may not qualify if:
- Patients with dementias from other causes, such as Lewy Body disease.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Gayatri Devi, MD
NY Memory
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
February 7, 2021
First Posted
February 25, 2021
Study Start
May 1, 2008
Primary Completion
May 30, 2020
Study Completion
May 30, 2020
Last Updated
February 25, 2021
Record last verified: 2021-02
Data Sharing
- IPD Sharing
- Will not share