Determination of Factors Related With Daily Living Activities in Severe COPD

NCT04765969 | Completed

• 1 other identifier: ssaka1
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

The main purpose of chronic obstructive pulmonary disease (COPD) rehabilitation applications is to increase the functional capacity of the patients and improve the quality of life in daily living activities (ADL). Therefore, the investigators planned the study to determine the influence of ADL and related factors in severe COPD. GOLD C and D COPD patients admitted to Bezmialem Vakif University Faculty of Health Sciences Department of Physiotherapy and Rehabilitation, Pulmonary Rehabilitation Application and Research Laboratory will be included in this study on a voluntary basis. Individuals who have experienced exacerbations of COPD in the last 6 weeks, have comorbidities affecting ambulation and have cognitive impairment will be excluded. Physical and sociodemographic characteristics of all participants will be recorded. Spirometric measurement will used to evaluate pulmonary functions, London Chest Activities Scale (LCADL) will used to evaluate daily living activities, six minute walking test (6MWT) will used to evaluate functional capacity, and mouth pressure will measured to evaluate respiratory muscle strength. (MIP: maximal inspiratory pressure, MEP: maximal expiratory pressure). Saint George Respiratory Questionnaire (SGRQ) for assessing quality of life, International Physical Activity Questionnaire (IPAQ) for assessing physical activity, COPD Assessment Test (CAT) for symptom assessment, and Hospital Anxiety and Depression Scale (HAD) for anxiety and depression assessment will be applied. SPSS 22.0 package program will be used in statistical analysis. For descriptive statistics, mean ± standard deviation values will be calculated and Pearson correlation test will be used in correlation analysis. p \<0.05 will be the level of significance.

Conditions

COPD

Keywords

COPD; Activities of Daily Living

Outcome Measures

Primary Outcomes (1)

• Activities of daily living

  The LCADL Scale is going to used to assess dyspnea resulting from ADL . It consists of a total of 15 items within four domains: personal care (4 items), domestic (6 items), physical (2 items), and leisure (3 items). Each item is graded from 0 to 5 with higher scores indicating more difficulty performing ADL. The scale can be evaluated as total score, domain scores, and item scores. The maximum total score is 75. There is also a single question that assesses to what degree dyspnea perception affects daily life in general. This item is answered by selecting one of three responses: 'a lot', 'a little', or 'not at all'

  6 months

Secondary Outcomes (10)

• Pulmonary Function Test

  6 months

• FEV1 (liter)

  6 months

• FEV1 (%-percentage)

  6 months

• FVC (liter)

  6 months

• FEV1/FVC (percentage)

  6 months

Other Outcomes (2)

• Health related quality of life assessment

  6 months

• Anxiety and depression

  6 months

Study Arms (1)

Severe COPD patients

GOLD C and D group patients

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

COPD subjects who were referred to the Bezmialem Vakıf University

You may qualify if:

• Pulmonary function tests (PFT) value of FEV₁ / FVC \<70%,
• Being in GOLD III-IV groups,
• Being over 18 years old,
• Being able to read and to understand the spoken language.

You may not qualify if:

• subjects have had COPD exacerbation in the last six weeks,
• having comorbidities affecting ambulation and
• cognitive disorders.

Sponsors & Collaborators

• Halic University: lead

Study Sites (1)

Bezmialem Vakıf University

Istanbul, 34350, Turkey (Türkiye)

Location

Related Publications (2)

• Ozsoy I, Ozcan Kahraman B, Acar S, Ozalevli S, Akkoclu A, Savci S. Factors Influencing Activities of Daily Living in Subjects With COPD. Respir Care. 2019 Feb;64(2):189-195. doi: 10.4187/respcare.05938. Epub 2018 Nov 6.

  PMID: 30401755 RESULT

• Kapella MC, Larson JL, Covey MK, Alex CG. Functional performance in chronic obstructive pulmonary disease declines with time. Med Sci Sports Exerc. 2011 Feb;43(2):218-24. doi: 10.1249/MSS.0b013e3181eb6024.

  PMID: 20543752 RESULT

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 7 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Vice-dean of Faculty of Health Sciences (PhD, PT)

Study Record Dates

• First Submitted: March 16, 2020
• First Posted: February 23, 2021
• Study Start: January 18, 2019
• Primary Completion: June 28, 2021
• Study Completion: June 30, 2021
• Last Updated: August 15, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)