The Frequency of Central Sensitization in Patients With Chronic Musculoskeletal Pain

NCT04765280 | Unknown

• 1 other identifier: 09.2021.114
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Central sensitization is as increased response to normal or sub-threshold stimuli of central nervous system and its close relationship with in many musculoskeletal diseases with chronic pain has been demonstrated in several studies. However, the effect of central sensitization on disability in these patients is not fully known. In this study, it was aimed to investigate the frequency of central sensitization and its effect on patients with chronic musculoskeletal pain who were admitted to physical medicine and rehabilitation outpatient clinics.

Conditions

Central Sensitisation; Chronic Musculoskeletal Disease; Chronic Pain

Keywords

central sensitization; central sensitization inventory; disability; chronic pain

Outcome Measures

Primary Outcomes (1)

• Central Sensitization Inventory (CSI)

  25 somatic and psychosocial symptoms, which are frequently found in patients with central sensitization in part A, are questioned. In part B, the presence of diseases whose relationship with central sensitization is well defined is questioned in the patient without participating in scoring. Central sensitization is assumed in patients who score 40 or more over 100 points.

  6 months

Secondary Outcomes (7)

• VAS pain

  6 months

• SF-36

  6 months

• Istanbul Low Back Pain Disability Index (ILBPDI)

  6 months

• The Neck Pain and Disability scale (NPAD)

  6 months

• Quick DASH

  6 months

Study Arms (1)

Patients with chronic musculoskeletal pain

Patients with any musculoskeletal pain for at least 3 months

Diagnostic Test: Central sensitization inventory; Other: Short form-36; Other: Istanbul Low Back Pain Disability Index; Other: Disabilities of the Arm, Shoulder and Hand (DASH); Other: Neck Pain and Disability scale; Other: Knee Injury and Osteoarthritis Outcome Score; Other: Western Ontario and McMaster Universities Arthritis Index; Other: Visual analogue scale

Interventions

Central sensitization inventory DIAGNOSTIC_TEST

Standardized questionnaire to determine the level of central sensitization. Patients with a score of 40 and above are considered to have central sensitization.

Also known as: CSI

Patients with chronic musculoskeletal pain

Short form-36 OTHER

Standardized questionnaire to investigate the quality of life in patients. The score of the scale is between 0-100. The higher scores are associated with greater deterioration in quality of life.

Also known as: SF-36

Patients with chronic musculoskeletal pain

Istanbul Low Back Pain Disability Index OTHER

Standardized questionnaire to investigate the disability in patients with low back pain. The score of the scale is between 0-90. It is accepted that the higher the score, the higher the disability.

Also known as: ILBPDI

Patients with chronic musculoskeletal pain

Disabilities of the Arm, Shoulder and Hand (DASH) OTHER

Standardized questionnaire to investigate the disability in patients with upper extremity musculoskeletal disorders. The score of the scale is between 0-100 It is accepted that the higher the score, the higher the disability.

Also known as: Quick DASH

Patients with chronic musculoskeletal pain

Neck Pain and Disability scale OTHER

Standardized questionnaire to investigate the disability in patients with neck pain. The score of the scale is between 0-100. It is accepted that the higher the score, the higher the disability.

Also known as: NPAD

Patients with chronic musculoskeletal pain

Knee Injury and Osteoarthritis Outcome Score OTHER

Standardized questionnaire to investigate the disability in patients with knee pain. The score of the scale is between 0-100It is accepted that the higher the score, the higher the disability.

Also known as: KOOS

Patients with chronic musculoskeletal pain

Western Ontario and McMaster Universities Arthritis Index OTHER

Standardized questionnaire to investigate the disability in patients with hip osteoarthritis. The score of the scale is between 0-240. It is accepted that the higher the score, the higher the disability.

Also known as: WOMAC

Patients with chronic musculoskeletal pain

Visual analogue scale OTHER

global pain score on a 0 to 10

Also known as: VAS

Patients with chronic musculoskeletal pain

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The patients aged 18-75 years diagnosed with chronic musculoskeletal disorders will be recruited from a PMR outpatient clinic of a state hospital

You may qualify if:

• Have musculoskeletal pain that lasts for at least 3 months
• Accepting to participate in the study

You may not qualify if:

• Have rheumatic disease

Sponsors & Collaborators

• Marmara University: lead

Study Sites (1)

Feyza Nur YUCEL

Sinop, 57200, Turkey (Türkiye)

Location

Related Publications (6)

• Woolf CJ, Thompson SW, King AE. Prolonged primary afferent induced alterations in dorsal horn neurones, an intracellular analysis in vivo and in vitro. J Physiol (Paris). 1988-1989;83(3):255-66.

  PMID: 3272296 RESULT

• Gervais-Hupe J, Pollice J, Sadi J, Carlesso LC. Validity of the central sensitization inventory with measures of sensitization in people with knee osteoarthritis. Clin Rheumatol. 2018 Nov;37(11):3125-3132. doi: 10.1007/s10067-018-4279-8. Epub 2018 Sep 3.

  PMID: 30178171 RESULT

• Nijs J, Malfliet A, Ickmans K, Baert I, Meeus M. Treatment of central sensitization in patients with 'unexplained' chronic pain: an update. Expert Opin Pharmacother. 2014 Aug;15(12):1671-83. doi: 10.1517/14656566.2014.925446. Epub 2014 Jun 15.

  PMID: 24930805 RESULT

• Roldan-Jimenez C, Perez-Cruzado D, Neblett R, Gatchel R, Cuesta-Vargas A. Central Sensitization in Chronic Musculoskeletal Pain Disorders in Different Populations: A Cross-Sectional Study. Pain Med. 2020 Nov 1;21(11):2958-2963. doi: 10.1093/pm/pnaa069.

  PMID: 32232473 RESULT

• Mayer TG, Neblett R, Cohen H, Howard KJ, Choi YH, Williams MJ, Perez Y, Gatchel RJ. The development and psychometric validation of the central sensitization inventory. Pain Pract. 2012 Apr;12(4):276-85. doi: 10.1111/j.1533-2500.2011.00493.x. Epub 2011 Sep 27.

  PMID: 21951710 RESULT

• Tanaka K, Murata S, Nishigami T, Mibu A, Manfuku M, Shinohara Y, Tanabe A, Ono R. The central sensitization inventory predict pain-related disability for musculoskeletal disorders in the primary care setting. Eur J Pain. 2019 Oct;23(9):1640-1648. doi: 10.1002/ejp.1443. Epub 2019 Aug 1.

  PMID: 31233655 RESULT

Related Links

• Neck pain and disability scale
• SF-36
• KOOS
• WOMAC

MeSH Terms

Conditions

Chronic Pain

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Canan ŞANAL TOPRAK, Asst.Prof

  Marmara University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 19, 2021
• First Posted: February 21, 2021
• Study Start: January 1, 2021
• Primary Completion: March 1, 2023
• Study Completion: March 30, 2023
• Last Updated: January 19, 2023

Record last verified: 2022-11

Locations

TU (1)