Comorbid Esophageal Disorders in IBS Patients

NCT04759378 | Unknown

• 1 other identifier: esophageal disorders and IBS
• Study Type: interventional
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

assess the incidence of the entire spectrum of esophageal disorders and possible theories for overlap in IBS patients using different diagnostic modalities.

Conditions

GERD; Non-erosive Reflux Disease; Functional Esophageal Disorders; Irritable Bowel Syndrome

Outcome Measures

Primary Outcomes (2)

• Incidence of GERD in IBS patients who have upper GIT symptoms

  use the result of the comprehensive examination, upper endoscopy, esophageal manometry, and 24h pH monitoring to reveal that comorbid disorders of the esophagus in patients with IBS.

  baseline

• Incidence of Functional esophageal disorders in IBS patient who have upper GIT symptoms.

  use the result of the comprehensive examination, including upper endoscopy, esophageal manometry, and 24h pH monitoring to reveal that comorbid disorders of the esophagus in patients with IBS.

  baseline

Study Arms (1)

IBS patients who have upper GIT symptoms

EXPERIMENTAL

Diagnostic Test: Upper endoscopy, esophageal manometry, 24-hour pH monitoring

Interventions

Upper endoscopy, esophageal manometry, 24-hour pH monitoring DIAGNOSTIC_TEST

upper endoscopy determines if there are structural abnormalities in upper Git. esophageal manometry determines if there are motility disorders. 24-hour pH monitoring determines if acid reflux is present or not, and specifies its rate and duration.

IBS patients who have upper GIT symptoms

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Established diagnosis of IBS (according to the Rome criteria of the III revision).
• Upper GIT symptoms in the form of heartburn (sometimes belching), a lump in the throat, and non-cardiac chest pain.

You may not qualify if:

• History of thoracic, esophageal, or gastric surgery.
• Presence of duodenal or gastric ulcer on upper endoscopy.
• Presence of duodenal or gastric cancer on upper endoscopy.
• Conditions that prevent the installation of a nasogastric tube (nasopharyngeal formation, severe lumen-facial trauma).
• mental disorders state and disability.
• Pregnancy and breastfeeding.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Gastroesophageal Reflux; Non-Erosive Reflux Disease; Irritable Bowel Syndrome

Interventions

Gastroscopy

Condition Hierarchy (Ancestors)

Esophageal Motility Disorders; Deglutition Disorders; Esophageal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Colonic Diseases, Functional; Colonic Diseases; Intestinal Diseases

Intervention Hierarchy (Ancestors)

Endoscopy, Gastrointestinal; Endoscopy, Digestive System; Diagnostic Techniques, Digestive System; Diagnostic Techniques and Procedures; Diagnosis; Endoscopy; Diagnostic Techniques, Surgical; Digestive System Surgical Procedures; Surgical Procedures, Operative; Minimally Invasive Surgical Procedures

Central Study Contacts

bishoy s shehata, doctor

CONTACT

+201271724586; bishoy.shehata77@gmail.com

hossam m Abdelwahaab, Lecturer

CONTACT

+201271724586; h.mahmoud@aun.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor at Assiut Univeristy Hospotal

Study Record Dates

• First Submitted: January 12, 2021
• First Posted: February 18, 2021
• Study Start: February 25, 2021
• Primary Completion: September 1, 2021
• Study Completion: October 1, 2021
• Last Updated: February 18, 2021

Record last verified: 2021-02