The Effect of Thyroid Hormon Levels on the Corneal Measures

NCT04752969 | Completed

• 1 other identifier: 30012021
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

In this cross-sectional comparative study, it is aimed to investigate the topographic measurements,aberrometrics and densitometrics values of corneas in hypothyroid and hyperthyroid patients compared to healthy individuals. A number of 20 hypothyroid patients (group I), 20 hyperthyroid patients (group II), and 20 age-matched healthy controls (group III) have been recruited. The Pentacam high resolution imaging system is used to determine corneal topographic measurements,aberrometry and densitometry.

Conditions

Thyroid Disorder; Corneal Opacity

Keywords

Thyroid disorder; Corneal opacity; Corneal aberrations

Outcome Measures

Primary Outcomes (1)

• corneal density in throid patients

  corneal density values according to type of thyroid disorder

  up to 12 weeks

Study Arms (3)

Hypothyroidia

20 subjects diagnosed with hypothyroidism

Hyperthyroidia

20 subjects diagnosed with hyperthyroidism

Healthy

20 age-matched healthy control subjects

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

20 patients diagnosed hypthyroidia ,20 patients diagnosed hyperthyroidia ,20 age matched healthy individuals

You may qualify if:

• Thyroid hormone disorder patients with a novel diagnosis
• Age-matched healthy individuals without any systemic disorder (e.g., diabetes mellitus, hypertension, rhematoid artritis, asthma etc.)

You may not qualify if:

• Having a spherical or cylindrical refractive error of \>1.0 degrees,
• Congenital corneal dystrophies, corneal ectasia, corneal ulcers or scars, keratitis, ocular surface infections, keratoconus,
• A history of ocular trauma,
• Uveitis,
• Glaucoma,
• A history of contact lens wear,
• A history of ocular surgery,
• Dry eye diseases

Sponsors & Collaborators

• Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital: lead

Study Sites (1)

Sağlık Bilimleri Üniversitesi Gazi Yaşargil Training and Research Hospital

Diyarbakır, 211100, Turkey (Türkiye)

Location

Related Publications (3)

• Cankurtaran V, Tekin K, Cakmak AI, Inanc M, Turgut FH. Assessment of corneal topographic, tomographic, densitometric, and biomechanical properties of Fabry patients with ocular manifestations. Graefes Arch Clin Exp Ophthalmol. 2020 May;258(5):1057-1064. doi: 10.1007/s00417-019-04593-8. Epub 2020 Jan 8.

  PMID: 31915973 RESULT

• Bilgihan K, Hondur A, Sul S, Ozturk S. Pregnancy-induced progression of keratoconus. Cornea. 2011 Sep;30(9):991-4. doi: 10.1097/ICO.0b013e3182068adc.

  PMID: 21705880 RESULT

• Villani E, Viola F, Sala R, Salvi M, Mapelli C, Curro N, Vannucchi G, Beck-Peccoz P, Ratiglia R. Corneal involvement in Graves' orbitopathy: an in vivo confocal study. Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4574-8. doi: 10.1167/iovs.10-5380. Epub 2010 Apr 30.

  PMID: 20435595 RESULT

MeSH Terms

Conditions

Thyroid Diseases; Corneal Opacity

Condition Hierarchy (Ancestors)

Endocrine System Diseases; Corneal Diseases; Eye Diseases

Study Officials

• Mehmet F Alakuş, MD

  Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor

Study Record Dates

• First Submitted: January 31, 2021
• First Posted: February 12, 2021
• Study Start: June 15, 2020
• Primary Completion: January 1, 2021
• Study Completion: January 1, 2021
• Last Updated: February 16, 2021

Record last verified: 2021-02

Locations

TU (1)