Effect of Lighting Supplementation on Daytime Cognition

NCT04745312 | Unknown

• 2 other identifiers: 2019P0009002020A011565
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study is to examine the efficacy of supplementing sub-optimal ambient room lighting with a task lamp on working memory and procedural learning.

Conditions

Non-visual Effects of Light

Keywords

Light; Cognition; Alertness; Learning

Outcome Measures

Primary Outcomes (1)

• Working memory

  Percent correct responses on a 2-minute mental arithmetic task

  8 hour light exposure

Secondary Outcomes (1)

• Procedural learning

  8 hour light exposure

Other Outcomes (5)

• Vigilance

  8 hour light exposure

• Subjective sleepiness

  8 hour light exposure

• Memory recall

  8 hour light exposure

Study Arms (2)

Ambient light

ACTIVE COMPARATOR

Fluorescent ambient lighting

Device: Visible light

Ambient light plus task lamp

EXPERIMENTAL

Fluorescent ambient lighting plus task lamp

Device: Visible light

Interventions

Visible light DEVICE

Ambient room lighting will be supplemented with additional light from a task lamp.

Ambient light; Ambient light plus task lamp

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Aged between 18-30 years;
• Healthy (no medical, psychiatric or sleep disorders;
• Non-smoking for at least 6 months;
• Body Mass Index of \>18 or \<30 kg/m2;
• Able to maintain 7-hour consistent sleep schedule during the study
• Able to refrain from caffeine, alcohol, medication and supplements during the study

You may not qualify if:

• History of alcohol or substance abuse;
• positive result on drugs of abuse urine toxicology;
• Current or past history of sleep disorders, including but not limited to obstructive sleep apnea, narcolepsy, insomnia, or any significant sleep complaint
• Psychiatric disorder, or first degree relative with a psychiatric disorder
• Recent acute or chronic medical disorder
• Use of drugs or medication (birth control OK) likely to affect sleep, alertness or light sensitivity, as determined by the investigators
• Visual disorder, including but not limited to color blindness, or family history of glaucoma
• Pregnancy or lactation
• Shift work (\> 2 nights / week in the last 3 months and not during the study)
• Transmeridian travel (2 or more time zones) in the past 3 months
• Any other reason as determine by the Principal Investigator

Sponsors & Collaborators

• Brigham and Women's Hospital: lead

Study Sites (1)

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

Location

Related Publications (1)

• Grant LK, Crosthwaite PC, Mayer MD, Wang W, Stickgold R, St Hilaire MA, Lockley SW, Rahman SA. Supplementation of ambient lighting with a task lamp improves daytime alertness and cognitive performance in sleep-restricted individuals. Sleep. 2023 Aug 14;46(8):zsad096. doi: 10.1093/sleep/zsad096.

  PMID: 37026184 DERIVED

Study Officials

• Shadab A Rahman, PhD, MPH

  Brigham and Women's Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Neuroscientist

Model Details: Randomized crossover

Study Record Dates

• First Submitted: February 4, 2021
• First Posted: February 9, 2021
• Study Start: March 1, 2021
• Primary Completion: March 1, 2022
• Study Completion: March 1, 2022
• Last Updated: February 18, 2022

Record last verified: 2022-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)