Cardiovascular Effects of Marathon Running

NCT04738877 | Completed

• 1 other identifier: EC-3/2020
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is the investigation of acute cardiovascular responses of marathon runners after the completion of a marathon race (42.2 km), as well as of the determinants of these changes.

Conditions

Athletes Heart

Outcome Measures

Primary Outcomes (8)

• Baseline left ventricular (LV) systolic function

  Evaluation of LV ejection fraction

  Evaluation of athletes within 3 weeks before the marathon running race.

• Baseline LV diastolic function

  Evaluation of LV filling pressures

  Evaluation of athletes within 3 weeks before the marathon running race.

• Baseline basal right ventricular (RV) function

  Evaluation of tricuspid annular plane systolic excursion (TAPSE)

  Evaluation of athletes within 3 weeks before the marathon running race.

• Baseline global RV function

  Evaluation of RV fractional are change (RVFAC)

  Evaluation of athletes within 3 weeks before the marathon running race.

• Post-exercise LV systolic function

  Evaluation of LV ejection fraction

  Evaluation of athletes immediately after the completion of the marathon running race.

• Post-exercise LV diastolic function

  Evaluation of LV filling pressures

  Evaluation of athletes immediately after the completion of the marathon running race.

• Post-exercise basal RV function

  Evaluation of TAPSE

  Evaluation of athletes immediately after the completion of the marathon running race.

• Post-exercise global RV function

  Evaluation of RVFAC

  Evaluation of athletes immediately after the completion of the marathon running race.

Interventions

Body fat measurement DIAGNOSTIC_TEST

Body fat measurement using skinfolds

Cardiopulmonary exercise testing DIAGNOSTIC_TEST

Electrocardiographic exercise testing with ergospirometer on a treadmill

Echocardiography DIAGNOSTIC_TEST

Transthoracic echocardiography

Blood test DIAGNOSTIC_TEST

Blood test for measurement of haemoglobin, serum electrolytes, iron, ferritin and vitamins

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Marathon runners aiming to paricipate in a marathon running race

You may qualify if:

• Marathon runner

You may not qualify if:

• Chronic disease, Drugs

Sponsors & Collaborators

• Aristotle University Of Thessaloniki: lead

Study Sites (1)

Aristotle University of Thessaloniki

Thessaloniki, Greece

Location

Related Publications (1)

• Christou GA, Pagourelias ED, Deligiannis AP, Kouidi EJ. Exploring the Anthropometric, Cardiorespiratory, and Haematological Determinants of Marathon Performance. Front Physiol. 2021 Sep 3;12:693733. doi: 10.3389/fphys.2021.693733. eCollection 2021.

  PMID: 34539429 DERIVED

MeSH Terms

Interventions

Exercise Test; Echocardiography; Hematologic Tests

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Ergometry; Investigative Techniques; Cardiac Imaging Techniques; Diagnostic Imaging; Ultrasonography; Clinical Laboratory Techniques

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Sports Medicine

Study Record Dates

• First Submitted: January 27, 2021
• First Posted: February 4, 2021
• Study Start: February 2, 2021
• Primary Completion: August 30, 2021
• Study Completion: August 30, 2021
• Last Updated: November 15, 2023

Record last verified: 2023-11

Locations

GR (1)