Ventilator Asynchrony as a Predictor of Weaning Failure

NCT04735497 | Completed

• 1 other identifier: Ventilator Asynchrony
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Patient ventilator asynchrony is a common problem in mechanically ventilated patients .It is associated with adverse effects including increased work of breathing, patient discomfort, increased need for sedation, prolonged mechanical ventilation , weaning difficulties and weaning failure. 100 mechanically ventilated COPD patients were enrolled in this prospective study .Detection of patient ventilator asynchrony was done on 30-minute sessions at 12, 24, 36, and 48 hours following intubation by visual assessment of pressure, flow and volume graphs on ventilator .

Conditions

Chronic Obstructive Pulmonary Disease(COPD)

Keywords

mechanically ventilated; weaning failure; COPD; asynchrony

Outcome Measures

Primary Outcomes (1)

• To study effect of different types of ventilator asynchrony on weaning in mechanically ventilated COPD patients

  Detection of patient ventilator asynchrony was done on 30-minute sessions following intubation by visual assessment of pressure, flow and volume graphs on ventilator .Repeated measures are done from the begining of mechanical ventilation and type of asynchronies including ineffective trigger double trigger, auto trigger , delayed cycle, early cycle and flow asynchrony. were recorded.

  One year

Study Arms (2)

Failed Weaning

Patients who failed to be liberated from mechanical ventillation

Successful Weaning

Patients who were liberated from mechanical ventillation and needed no respiratory support

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All COPD patients who were diagnosed after history ,physical examination ,radiology and pulmonary function tests and required mechanical ventilation.

You may qualify if:

• All COPD patients who were diagnosed after history ,physical examination radiology and pulmonary function tests and required mechanical ventilation.

You may not qualify if:

• Age \< 18 years
• Tracheostomy
• Failure to trigger breaths even in cases of receiving neuromuscular blocking agents.
• Encephalopathy which is not caused by hypercapnia or hypoxemia either post arrest or due to cerebrovascular stroke
• Patients with unplanned weaning
• COPD patients where intubation not related to exacerbation e.g. acute pulmonary edema.

Sponsors & Collaborators

• Reham Mohammed Elmorshedy: lead

Study Sites (1)

Assuit University Hospital

Asyut, 71515, Egypt

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Samiaa Sadek, Ass.Lecturer

  Assiut University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: January 11, 2021
• First Posted: February 3, 2021
• Study Start: February 15, 2018
• Primary Completion: August 15, 2019
• Study Completion: December 20, 2019
• Last Updated: February 10, 2021

Record last verified: 2021-02

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)