Effects of Inspiratory and Expiratory Pressure Training Methods in Patients With Chronic Obstructive Pulmonary Disease

NCT02326181 | Unknown DMC

• 1 other identifier: ZJH21400964
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The study will investigate the effects of different training types ,including combined inspiratory with expiratory pressure threshold training,inspiratory pressure threshold training on patients with chronic obstructive airway disease and investigate whether expiratory pressure threshold training associated with inspiratory pressure threshold training would be better than inspiratory pressure threshold training alone, with regard to exercise capacity, respiratory muscle strength and endurance.

Conditions

Chronic Obstructive Pulmonary Disease(COPD)

Keywords

respiratory muscle training; respiratory muscle strength; respiratory endurance test; 6-minute walking test

Outcome Measures

Primary Outcomes (1)

• respiratory muscle strength measurements

  baseline and 8 weeks

Secondary Outcomes (4)

• respiratory muscle endurance text

  baseline and 8 weeks

• 6-minute walking test

  baseline and 12 weeks

• perceived exertion for leg fatigue (Borg-scale)

  baseline and 8 weeks

• modified british medical research council(mMRC) questionnaire

  baseline and 8 weeks

Study Arms (3)

control group

NO INTERVENTION

without inspiratory and expiratory pressure threshold training

inspiratory pressure training group

EXPERIMENTAL

The patients will perform daily in 2 sessions of 30 minutes, using a pressure threshold trainer.

Device: inspiratory pressure training group

mixed training group

EXPERIMENTAL

The patients will perform daily in 2 sessions of 30 minutes, using a pressure threshold trainer.

Device: mixed training group

Interventions

inspiratory pressure training group DEVICE

The respiratory pressure load device can be provided different loads to perform inspiratory and expiratory pressure training.In the study,pressure-threshold respiratory trainers were calibrated to provide different loads against inspiration (IMST) .

inspiratory pressure training group

mixed training group DEVICE

The respiratory pressure load device can be provided different loads to perform inspiratory and expiratory pressure training.In the study,pressure-threshold respiratory trainers were calibrated to provide different loads against inspiration (IMST) and expiration(EMST).

mixed training group

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Clinically stable COPD with diagnosis of forced expiratory volume at one second(FEV1)/forced vital capacity(FVC) \< 70%

You may not qualify if:

• Cancer Unstable heart disease Neuromusculoskeletal disorder mental disorder Active smokers

Sponsors & Collaborators

• Zhujiang Hospital: lead

Study Sites (1)

Zhujiang hospital

Guangzhou, Guangdong, 510000, China

Location

Related Publications (1)

• Xu W, Li R, Guan L, Wang K, Hu Y, Xu L, Zhou L, Chen R, Chen X. Combination of inspiratory and expiratory muscle training in same respiratory cycle versus different cycles in COPD patients: a randomized trial. Respir Res. 2018 Nov 20;19(1):225. doi: 10.1186/s12931-018-0917-6.

  PMID: 30458805 DERIVED

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Xin Chen, Doctor

  Zhujiang Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Liqing Wang, Doctor

CONTACT

+86-02062783391; wliqing07@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 21, 2014
• First Posted: December 25, 2014
• Study Start: January 1, 2015
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2016
• Last Updated: December 25, 2014

Record last verified: 2014-12

Locations

CN (1)