Effect of Using Different Varnishes on Dentin Hypersensitivity; Na Fluoride and Nano-silver Fluoride

NCT04731766 | Unknown

• 1 other identifier: 205
• Study Type: interventional
• Target: 42
• Locations: 0 countries
• Sites: N/A

Brief Summary

2 different varnishes will be used to test their effectiveness in controlling teeth hypersensitivity in adult patient.

Conditions

Dentin Hypersensitivity

Outcome Measures

Primary Outcomes (1)

• change in dentin Hypersensitivity

  Visual Analogue Scale (VAS) will be used; 0 is no pain and 10 is severe pain. Pictures are added to the same, as well as colors to guide the patient during selection of pain severity.

  1 week, 4 weeks & 8 weeks

Secondary Outcomes (1)

• change in dentinal Tubule Occlusion

  1 week, 4 weeks * 8 weeks

Study Arms (2)

Citrine 5% Sodium Fluoride

ACTIVE COMPARATOR

It was developed to prolong the contact between the tooth surface and fluoride to increase the resistance against caries attack and manage tooth hypersensitivity; the active ingredient of fluoride varnish is mostly 5% sodium fluoride.

Behavioral: Citrine 5 % sodium fluoride

concocuted Nano-silver fluoride

EXPERIMENTAL

Nano-silver fluoride (NSF) is a laboratory synthesized solution

Behavioral: concocted nano-silver fluoride

Interventions

Citrine 5 % sodium fluoride BEHAVIORAL

Citrine varnish is a 5% sodium fluoride varnish, It was developed to prolong the contact between the tooth surface and fluoride to increase the resistance against caries attack and manage tooth hypersensitivity; the active ingredient of fluoride varnish is mostly 5% sodium fluoride.

Citrine 5% Sodium Fluoride

concocted nano-silver fluoride BEHAVIORAL

Nano-silver fluoride (NSF) is a solution which has been introduced as an experimental formulation in which it's stability for three years has been proved by Santos et al. The laboratory synthesis of concocted NSF was carried out in a nano-technology center; Several trials were done until we have reached a successful end product.

concocuted Nano-silver fluoride

Eligibility Criteria

• Age: 25 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients consulting in one of the Qasr Einy, faculty of dentistry outpatient clinics.
• Males or females.
• Patient's age range 25-50 years.
• Patients complaining of hypersensitive areas on facial surfaces of the teeth (incisors, cuspids, bi-cuspids, and first molars with exposed cervical dentine) with teeth scoring Bpain (VAS score: greater than or equal to 3) during application of stimulus (airblast and tactile sensitivity test).
• Tooth with exposed root surface, complaining from hypersensitivity (VAS score; greater than or equal to 3).
• Patients accept the 2-months follow-up period.
• Provide informed consent.

You may not qualify if:

• Patients participating in another dental study that may alter the results of this study.
• A medical condition that could hinder the accuracy of pain reporting (e.g., pain disorders).
• Any chronic medical condition that requires the regular use of anti-inflammatory pain medications.
• Patients used or applied a desensitizing varnish within the last four weeks.
• Patients with dental problems; chipped teeth, defective restorations, fractured Un-displaced cuspids or deep dental caries.
• Lack of patient's approval and compliance.

Sponsors & Collaborators

• Nayera Hassanien Mohamed: lead

MeSH Terms

Conditions

Dentin Sensitivity

Interventions

Sodium Fluoride

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Fluorides; Hydrofluoric Acid; Fluorine Compounds; Inorganic Chemicals; Sodium Compounds; Cariostatic Agents; Biomedical and Dental Materials; Manufactured Materials; Technology, Industry, and Agriculture

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Lecturer

Study Record Dates

• First Submitted: October 6, 2020
• First Posted: February 1, 2021
• Study Start: November 1, 2021
• Primary Completion: January 1, 2022
• Study Completion: January 1, 2022
• Last Updated: February 1, 2021

Record last verified: 2021-01

Data Sharing

• IPD Sharing: Will not share