Determine the Effect of Prone Positioning in Adults With ARDS by Electrical Impedance Tomography

NCT04725227 | Unknown DMC

• 1 other identifier: P-E
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

determine the effect of prone positioning on ventilation and perfusion distribution in adults with acute respiratory distress syndrome by electrical impedance tomography

Conditions

ARDS; Prone Position; Electrical Impedance Tomography

Outcome Measures

Primary Outcomes (3)

• Assess regional distribution of pulmonary perfusion

  To evaluate the effect of prone positon on pulmonary blood flow distribution.

  within 24 hours

• Assess regional distribution of pulmonary ventilation

  To evaluate the effect of prone positon on pulmonary vetilation distribution.

  within 24 hours

• Assess oxygenation status

  To evaluate the effect of prone position by assessing regional distribution of pulmonary perfusion based on indicator dilution and changes at different points in time during varying states of regional ventilation will be evaluated.

  within 24 hours

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients requiring mechanical ventilation are recieved prone position ventilation who admitted to the surgical ICU.

You may qualify if:

• patients who were undergoing mechanical ventilation with moderate-to-severe ARDS (defined as a Pao2:Fio2 ratio \< 150 mm Hg with a positive end-expiratory pressure ≥ 5 cm of water, and an Fio2 of ≥ 0.6) according to the Berlin definition

You may not qualify if:

• contraindications to the use of EIT (e.g., presence of pacemaker or chest surgical wounds dressing)

Sponsors & Collaborators

• Shanghai Zhongshan Hospital: lead

Study Sites (1)

Zhongshan Hospital of Fudan University

Shanghai, Shanghai Municipality, 200032, China

RECRUITING

Related Publications (3)

• Wang Y, Muhetaer Y, Zheng X, Wu W, Tao J, Zhu L, Song J, Zhao Z, Zhong M. Time-dependent effects of prone position on ventilation-perfusion matching assessed by electrical impedance tomography in patients with COVID-19 ARDS: sub-analysis of a prospective physiological study. Ann Intensive Care. 2025 Mar 31;15(1):46. doi: 10.1186/s13613-025-01452-0.

  PMID: 40163279 DERIVED

• Wang Y, Song J, Lin S, Zheng X, Zhao Z, Zhong M. Influence of Prone Position on Regional Ventilation/Perfusion Matching in Patients With ARDS Over Time. Respir Care. 2025 Jul;70(7):821-829. doi: 10.1089/respcare.12247. Epub 2025 Mar 5.

  PMID: 40040422 DERIVED

• Wang YX, Zhong M, Dong MH, Song JQ, Zheng YJ, Wu W, Tao JL, Zhu L, Zheng X. Prone positioning improves ventilation-perfusion matching assessed by electrical impedance tomography in patients with ARDS: a prospective physiological study. Crit Care. 2022 May 27;26(1):154. doi: 10.1186/s13054-022-04021-0.

  PMID: 35624489 DERIVED

Study Officials

• Ming Zhong, MD, phD

  Fudan University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ming Zhong, MD, phD

CONTACT

021-65642662; zhong.ming@zs-hospital.sh.cn

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 25, 2021
• First Posted: January 26, 2021
• Study Start: December 1, 2020
• Primary Completion: December 1, 2022
• Study Completion: December 31, 2022
• Last Updated: January 26, 2021

Record last verified: 2021-01

Locations

CN (1)