The Association Between Sedentary Behaviour and Cardiometabolic Health in Trained Athletes

NCT04711928 | Completed

• 1 other identifier: CME2020/012
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Physical inactivity is one of the major contributing factors for the development of chronic diseases and highly correlated with increased all-cause mortality. In the last decade an exponential growth in research concerned with the study of sedentary behaviour and the potential for detrimental effects on health have been published. In this field increasing evidence suggests that prolonged periods of sedentary time, independent of the amount of physical activity, also increases the risk for the development of several chronic conditions and all-cause mortality. Here, sedentary behaviour is defined as "any waking behaviour, characterized by a low energy expenditure (≤1.5 METs), while being in a sitting or reclining posture". Interestingly, the advised moderate-to-vigorous bouts of exercise recommended by the various guidelines cannot compensate the negative impact on health risks arising from prolonged periods of sitting. In other words, it seems that people compensate their total amount of physical activity after exercise training by decreasing their physical activity levels throughout the rest of the day. Here, it appears that frequent, even low-intensity interruptions of periods of sitting are required for good cardiometabolic health. Therefore, not only physical activity but also prolonged sitting should be targeted to optimize cardiometabolic health. Nevertheless, a recent harmonized meta-syntheses indicated that the association between self-reported sitting with all-cause and cardiovascular disease mortality are only partially independent of physical activity, but were particularly evident in those who undertake insufficient physical activity (\<150min/week). However, it is unclear whether high amounts of objectively measured physical activity attenuates or even eliminates the detrimental effects of prolonged sitting. In addition, it is still unclear whether high amounts of physical activity can preserve a healthy cardiometabolic risk profile, despite prolonged sitting. Therefore, in this study we want to investigate the association between sedentary behaviour, physical activity and cardiometabolic health in highly physically active adults.

Conditions

Cardiometabolic Health; Sedentary Behavior; Physical Activity; Athletes

Outcome Measures

Primary Outcomes (1)

• Sedentary time (min/day)

  Main outcome parameter of sedentary behaviour indication measured with ActivPAL3

  day 1

Secondary Outcomes (13)

• Moderate-to-vigorous physical activity time (min/day)

  day 1

• Light physical activity time (min/day)

  day 1

• Blood glucose concentration

  day 1

• Blood insulin concentration

  day1

• Blood total cholesterol concentration

  day 1

Study Arms (1)

Trained athletes

Active individuals with at least 4 training hours per week.

Behavioral: Physical activity and sedentary behaviour

Interventions

Physical activity and sedentary behaviour BEHAVIORAL

Athletes with a high physical activity and a low or high sedentary time

Trained athletes

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Active individuals with at least 4 training hours per week and between 18 and 45 years of age.

You may qualify if:

• Active individuals with at least 4 training hours per week

You may not qualify if:

• pregnancy
• Any known contradiction for physical activity
• Systolic blood pressure \>160mmHg, diastolic blood pressure \>100mmHg
• More than 20 alcohol consumptions per week
• Participants diagnosed with any known chronic disease

Sponsors & Collaborators

• Hasselt University: lead

Study Sites (1)

Wouter Franssen

Diepenbeek, Limburg, 3590, Belgium

Location

Related Publications (1)

• Franssen WMA, Jermei J, Savelberg HHCM, Eijnde BO. The potential harms of sedentary behaviour on cardiometabolic health are mitigated in highly active adults: a compositional data analysis. J Act Sedentary Sleep Behav. 2023 Mar 2;2(1):6. doi: 10.1186/s44167-023-00015-7.

  PMID: 40217441 DERIVED

MeSH Terms

Conditions

Sedentary Behavior; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 13, 2021
• First Posted: January 15, 2021
• Study Start: January 10, 2021
• Primary Completion: August 1, 2021
• Study Completion: October 1, 2021
• Last Updated: March 15, 2022

Record last verified: 2022-03

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)