NCT04708028

Brief Summary

A cross-sectional prospective study measuring physiologic biometrics and perceptions of stress during a dental procedure with or without a therapy dog present.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40

participants targeted

Target at below P25 for not_applicable anxiety

Timeline
Completed

Started Jul 2021

Longer than P75 for not_applicable anxiety

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 11, 2021

Completed
2 days until next milestone

First Posted

Study publicly available on registry

January 13, 2021

Completed
6 months until next milestone

Study Start

First participant enrolled

July 26, 2021

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 22, 2023

Completed
9 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 4, 2024

Completed
6 months until next milestone

Results Posted

Study results publicly available

August 19, 2024

Completed
Last Updated

August 19, 2024

Status Verified

March 1, 2024

Enrollment Period

1.9 years

First QC Date

January 11, 2021

Results QC Date

March 22, 2024

Last Update Submit

March 22, 2024

Conditions

Outcome Measures

Primary Outcomes (2)

  • Mean Salivary Amylase Levels Throughout Dental Visit

    To measure stress levels salivette swab will be placed in child's cheek to absorb saliva.

    Up to end of dental visit; a total average between 60 to 90 minutes

  • Mean Salivary Cortisol Levels Throughout Dental Visit

    To measure stress levels salivette swab will be placed in child's cheek to absorb saliva.

    Up to end of dental visit; a total average between 60 to 90 minutes

Study Arms (2)

Control

NO INTERVENTION

No exposure to the therapy dog.

Dog Therapy

EXPERIMENTAL

Introduced to a therapy dog and allowed to pet the dog for up to 2 minutes (timed) prior to the dental procedure.

Other: Dog Therapy

Interventions

The intervention is a therapy dog interaction (e.g. petting) for up to 2 minutes before their appointment and first interaction with the doctor. The subject can pet the dog for as long as they like up until the 2 minute mark.

Dog Therapy

Eligibility Criteria

Age7 Years - 17 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • years of age
  • Patient undergoing 1 quadrant restorative dental procedure requiring a handpiece (e.g. multiple fillings, sealants and/or stainless-steel crowns) and/or extraction(s)
  • History of moderate dental anxiety with a Frankl score of 2-3 based on Epic chart review

You may not qualify if:

  • Patients with developmental delay/special needs, Autism Spectrum Disorders (ASDs), craniofacial defects, chronic pain conditions, and/or dental syndromes
  • No history of dental anxiety
  • Moderate to severe allergy to dogs
  • Previous traumatic experience with a dog and/or self-reported fear of dogs
  • Patients who are not receiving dental care requiring a handpiece (for ex, prophylaxis only)
  • Patients with severe, documented xerostomia
  • Patients receiving sedation (pharmacological and conscious sedation) or general anesthesia
  • Patients who will have physical restraints placed during the dental procedure
  • Patient scheduled to have sedation or general anesthesia
  • Severe acute or chronic medical or psychiatric condition(s) that would interfere with the interpretation of results, and in the judgement of the Investigator, would make the subject inappropriate for entry into the trial
  • Patient with developmental/cognitive disability that cannot self-assent, comprehend and follow the requirements of the study based on research site personnel's assessment.
  • Inability or unwillingness of individual and legal guardian/representative to give written informed assent (from child) and consent (from adult).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

General & Oral Health Center

Chapel Hill, North Carolina, 27599, United States

Location

Related Publications (1)

  • Massouda J, Ghaltakhchyan N, Judd J, Bocklage C, Selden R, TumSuden O, Nanney E, Lee J, Ginnis J, Strauman T, Sawicki C, Hodges EA, Graves C, Divaris K, Jacox L. Evaluating effects of animal-assisted therapy on pediatric dental care patients: A pilot clinical trial. J Am Dent Assoc. 2025 Jun;156(6):447-457.e14. doi: 10.1016/j.adaj.2025.03.006.

MeSH Terms

Conditions

Anxiety Disorders

Condition Hierarchy (Ancestors)

Mental Disorders

Results Point of Contact

Title
Laura Jacox, DMD, PhD
Organization
University of North Carolina at Chapel Hill

Study Officials

  • Laura A Jacox, DMD, PhD, MS

    University of North Carolina, Chapel Hill

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 11, 2021

First Posted

January 13, 2021

Study Start

July 26, 2021

Primary Completion

June 22, 2023

Study Completion

March 4, 2024

Last Updated

August 19, 2024

Results First Posted

August 19, 2024

Record last verified: 2024-03

Data Sharing

IPD Sharing
Will share

Deidentified individual data that supports the results will be shared beginning following publication up to 1 year provided the investigator who proposes to use the data has approval from an Institutional Review Board (IRB), Independent Ethics Committee (IEC), or Research Ethics Board (REB), as applicable, and executes a data use/sharing agreement with UNC.

Shared Documents
STUDY PROTOCOL
Time Frame
1 month following publication up to 1 year
Access Criteria
Deidentified individual data that supports the results will be shared beginning following publication up to 1 year provided the investigator who proposes to use the data has approval from an IRB, IEC, or REB as applicable, and an executed data use/sharing agreement with University of North Carolina (UNC).

Locations