VDR SNPs & 25OHD Correlated With Dyslipidemia

NCT04707612 | Completed

• 1 other identifier: QLS2015
• Study Type: observational
• Target: 1,987
• Locations: 1 country
• Sites: 1

Brief Summary

The project was aimed to explore the associations of single nucleotide polymorphisms (SNPs) of vitamin D receptor gene with specific circulating lipids in adult Chinese. The circulating 25-hydroxyvitamin D concentration was also tested to explore its interactions with SNPs in the associations.

Conditions

Dyslipidemias; Single Nucleotide Polymorphism

Keywords

gene polymorphism; vitamin D receptor; vitamin D; lipid; dyslipidemia

Outcome Measures

Primary Outcomes (3)

• SNPs of VDR

  Polymorphisms of vitamin D receptor gene: Cdx2, Fok1, Apa1, and Taq1

  6 months

• lipid profiles

  Serum concentrations of TG, TC, LDLC, and HDLC

  6 months

• 25OHD

  Plasma 25-hydroxyvitamin D concentration

  6 months

Interventions

No intervention. OTHER

No intervention.

Eligibility Criteria

• Age: 20 Years - 81 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult volunteers visiting a health examination center in Shenzhen city of Guangdong province, China were recruited. A total of 1,987 adults were included in the analysis, aged from 20 to 81 years old. Among them, there were 1,124 females aged 39 (31 - 49) years old and 863 males aged 36 (30 - 44) years old.

You may qualify if:

• \) ≥ 20 years old Han Chinese;
• \) living in Shenzhen for \> 2 years;
• \) free of liver diseases, renal diseases, and any cancers in the past 6 months; and
• \) not in pregnancy for women.

You may not qualify if:

• \) had severe organic diseases,
• \) had acute infection symptoms, allergic diseases, and malignant tumors,
• \) had a family history of genetic diseases,
• \) took VD supplements in the past 6 months,
• \) took medicines to control lipid levels within 12 hours, or
• \) took diuretics, did strenuous exercise, or overate within 24 hours before the test.

Sponsors & Collaborators

• Shenzhen Center for Chronic Disease Control: lead
• Sun Yat-sen University: collaborator

Study Sites (1)

Shenzhen Center for Chronic Disease Control

Shenzhen, Guangdong, 518020, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples were collected for plasma or serum and DNA isolations.

MeSH Terms

Conditions

Dyslipidemias

Condition Hierarchy (Ancestors)

Lipid Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Molecular Biology Laboratory

Study Record Dates

• First Submitted: January 10, 2021
• First Posted: January 13, 2021
• Study Start: July 1, 2013
• Primary Completion: January 31, 2014
• Study Completion: October 31, 2016
• Last Updated: January 13, 2021

Record last verified: 2021-01

Locations

CN (1)