Research Study to Compare Three Doses of Semaglutide Tablets Taken Once Daily in People With Type 2 Diabetes
PIONEER PLUS
Efficacy and Safety of Once-daily Oral Semaglutide 25 mg and 50 mg Compared With 14 mg in Subjects With Type 2 Diabetes
3 other identifiers
interventional
1,606
14 countries
218
Brief Summary
This study compares three doses of once daily semaglutide tablets in people with type 2 diabetes who were previously treated with other oral anti-diabetic medicines. Participants will be initiated on the lowest starting dose of 3 mg and gradually increased until they reach the final trial dose of 14 mg, 25 mg or 50 mg once daily semaglutide tablets. The final three doses will be randomized (i.e., decided by chance). Participants will be administered one tablet per day for 68 weeks. Women cannot take part if they are pregnant, breast-feeding or planning to become pregnant during the study period. Women who can get pregnant will be checked for pregnancy via urine tests. Once daily semaglutide tablets (3 mg, 7 mg and 14 mg) are approved for the treatment of type 2 diabetes in the US, in the EU and in some other countries, under the brand name Rybelsus®.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 diabetes-mellitus-type-2
Started Jan 2021
Typical duration for phase_3 diabetes-mellitus-type-2
218 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 12, 2021
CompletedFirst Posted
Study publicly available on registry
January 13, 2021
CompletedStudy Start
First participant enrolled
January 15, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 7, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
March 8, 2023
CompletedResults Posted
Study results publicly available
April 3, 2024
CompletedDecember 9, 2025
November 1, 2025
2.1 years
January 12, 2021
March 5, 2024
November 24, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Change From Baseline in Glycated Haemoglobin (HbA1c) (Week 52)
Change from baseline (week 0) in glycosylated haemoglobin (HbA1c) was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment. Percentage point refers to arithmetic difference between two percentages.
Baseline (week 0), week 52
Secondary Outcomes (38)
Change From Baseline in Body Weight (Week 52)
Baseline (week 0), week 52
Change From Baseline in HbA1c (Week 68)
Baseline (week 0), week 68
Change From Week 12 in HbA1c (Week 52)
Week 12, Week 52
Change From Baseline in Fasting Plasma Glucose (FPG) (Week 52)
Baseline (week 0), week 52
Change From Baseline in FPG (Week 68)
Baseline (week 0), week 68
- +33 more secondary outcomes
Study Arms (3)
Oral semaglutide 50 mg
EXPERIMENTALParticipants will receive once daily semaglutide tablets in a dose escalating manner for 68 weeks: 3 mg (week 1-4), 7 mg (week 5-8), 14 mg (week 9-12), 25 mg (week 13-16) and 50 mg (week 17-68).
Oral semaglutide 25 mg
EXPERIMENTALParticipants will receive once daily semaglutide tablets in a dose escalating manner for 68 weeks: 3 mg (week 1-4), 7 mg (week 5-8), 14 mg (week 9-12) and 25 mg (week 13-68).
Oral semaglutide 14 mg
ACTIVE COMPARATORParticipants will receive once daily semaglutide tablets in a dose escalating manner for 68 weeks: 3 mg (week 1-4), 7 mg (week 5-8) and 14 mg (week 9-68).
Interventions
Participants will receive once daily semaglutide tablets (oral administration) in a dose escalating manner for 68 weeks.
Eligibility Criteria
You may qualify if:
- Male or female, age above or equal to 18 years at the time of signing informed consent.
- Diagnosed with type 2 diabetes mellitus at least 180 days prior to the day of screening.
- HbA1c of 8.0-10.5% (64-91 mmol/mol) (both inclusive).
- BMI equal to or above 25 kg/m\^2
- Stable daily dose(s) for 90 days prior to the day of screening of any of the following treatment regimens:
- No more than 3 of the following oral anti-diabetic drugs and at least 1 marked with a \*:
- Metformin (equal to or above1500 mg or maximum tolerated or effective dose).
- Sulfonylureas (SU) (equal to or above half of the maximum approved dose according to local label or maximum tolerated or effective dose).
- Sodium/glucose cotransporter 2 (SGLT2) inhibitors (maximum tolerated dose).
- Dipeptidyl peptidase-4 (DPP-4) inhibitors (maximally indicated dose as per local label).
You may not qualify if:
- Renal impairment measured as estimated glomerular filtration rate (eGFR) value of below 30 mL/min/1.73 m\^2 according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation as defined by kidney disease improving global outcomes (KDIGO 2012) classification.
- Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within the past 90 days prior to screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Novo Nordisk A/Slead
Study Sites (228)
American Clinical Trials
Buena Park, California, 90620, United States
Valley Research
Fresno, California, 93720, United States
Velocity Clin Res San Diego
La Mesa, California, 91942, United States
First Valley Medical Group
Lancaster, California, 93534, United States
Pacific Clinical Studies
Los Alamitos, California, 90720, United States
Velocity Clin Res Los Angeles
Los Angeles, California, 90017, United States
Diabetes Medical Center Of California
Northridge, California, 91325, United States
Desert Oasis Hlthcr Med Group
Palm Springs, California, 92262, United States
Gateway Research Center
Poway, California, 92064, United States
Encompass Clinical Research_Spring Valley
Spring Valley, California, 91978, United States
Diablo Clinical Research, Inc.
Walnut Creek, California, 94598, United States
San Fernando Valley Hlth Inst, LLC
West Hills, California, 91304, United States
University of Colorado Hospital
Aurora, Colorado, 80045, United States
Optumcare Clinical Trials,LLC-Golden
Colorado Springs, Colorado, 80906, United States
Chase Medical Research LLC
Waterbury, Connecticut, 06708, United States
Alliance for Multispec Res
Coral Gables, Florida, 33134, United States
Northeast Research Institute
Jacksonville, Florida, 32204, United States
San Marcus Res Clin Miami Lakes
Miami Lakes, Florida, 33014, United States
Complete Health Research
Ormond Beach, Florida, 32174-6302, United States
Clinical Trial Res Assoc,Inc
Plantation, Florida, 33324, United States
Progressive Medical Research
Port Orange, Florida, 32127, United States
Endo Res Solutions Inc
Roswell, Georgia, 30076, United States
East West Med Res Inst
Honolulu, Hawaii, 96814, United States
Elite Clinical Trials
Blackfoot, Idaho, 83221, United States
Rocky Mt Clin Res, LLC
Idaho Falls, Idaho, 83404-7596, United States
Solaris Clinical Research
Meridian, Idaho, 83646, United States
Cedar-Crosse Research Center
Chicago, Illinois, 60607, United States
Macoupin Research Group
Gillespie, Illinois, 62033, United States
UnityPoint Health-Diabetes Care Center
Peoria, Illinois, 61603, United States
Evanston Premier Hlthcr Res
Skokie, Illinois, 60077, United States
Midwest Inst For Clin Res
Indianapolis, Indiana, 46260, United States
Iowa Diab & Endo Res Center
West Des Moines, Iowa, 50266, United States
Cotton O'Neil Diab & Endo Ctr
Topeka, Kansas, 66606, United States
The Research Group of Lexington LLC
Lexington, Kentucky, 40503, United States
L-MARC Research Center
Louisville, Kentucky, 40213, United States
Pennington Biom Res Ctr
Baton Rouge, Louisiana, 70808, United States
Centex Studies, Inc._Lake Charles
Lake Charles, Louisiana, 70601, United States
MD Medical Research
Oxon Hill, Maryland, 20745, United States
Brigham & Women's Hospital
Boston, Massachusetts, 02115-5804, United States
MassResearch, LLC
Waltham, Massachusetts, 02453, United States
Aa Mrc Llc
Flint, Michigan, 48504, United States
Arcturus Healthcare, PLC.
Troy, Michigan, 48098, United States
Mercury Str Med Grp, PLLC
Butte, Montana, 59701, United States
Univ of Nebraska Medical CTR
Omaha, Nebraska, 68198-3020, United States
University of Nebraska Medical Center-Diabetes Center
Omaha, Nebraska, 68198-4120, United States
Premier Research Inc.
Trenton, New Jersey, 08611, United States
UNC Diabetes Care Center_Chapel Hill
Chapel Hill, North Carolina, 27514, United States
PharmQuest Life Sciences LLC
Greensboro, North Carolina, 27408, United States
Accellacare
Wilmington, North Carolina, 28401, United States
Lillestol Research LLC
Fargo, North Dakota, 58104, United States
Rapid Medical Research Inc
Cleveland, Ohio, 44122, United States
Prestige Clinical Research
Franklin, Ohio, 45005, United States
Albert J Weisbrot
Mason, Ohio, 45040, United States
Intend Research
Norman, Oklahoma, 73069, United States
Corvallis Clinic PC Clinical Research Department
Corvallis, Oregon, 97330-3737, United States
Preferred Primary Care Physicians_Pittsburgh
Pittsburgh, Pennsylvania, 15236, United States
Palmetto Clinical Research
Greenville, South Carolina, 29615, United States
Palmetto Clinical Research
Summerville, South Carolina, 29485, United States
Holston Medical Group Pc
Bristol, Tennessee, 37620-7352, United States
Chattanooga Medical Research, LLC
Chattanooga, Tennessee, 37404, United States
Murphy Research Center
Humboldt, Tennessee, 38343, United States
Clinical Neuroscience Solutions
Memphis, Tennessee, 38119, United States
Arlington Family Res. Ctr Inc
Arlington, Texas, 76012-4637, United States
Velocity Clinical Res-Dallas
Dallas, Texas, 75230, United States
Velocity Clinical Research, Dallas
Dallas, Texas, 75230, United States
UT Southwestern Med Cntr
Dallas, Texas, 75390-9302, United States
Care United Research, LLC
Forney, Texas, 75126, United States
JCCT- Juno NW Houston
Houston, Texas, 77040, United States
JCCT- Juno NW Houston
Houston, Texas, 77074, United States
Southwest Clinical Trials
Houston, Texas, 77074, United States
Family Practice Care Associates
Humble, Texas, 77338, United States
Research Trials Worldwide LLC
Humble, Texas, 77338, United States
Juno Research, LLC_Cary
Katy, Texas, 77450, United States
DCOL Ctr for Clin Res
Longview, Texas, 75605, United States
Research Institute Of Dallas
Plano, Texas, 75093, United States
VIP Trials
San Antonio, Texas, 78230, United States
VIP Trials
San Antonio, Texas, 78231, United States
Consano Clinical Research, LLC
Shavano Park, Texas, 78231, United States
Simcare Medical Research, LLC
Sugar Land, Texas, 77478, United States
Health Res of Hampton Roads
Newport News, Virginia, 23606, United States
York Clinical Research LLC
Norfolk, Virginia, 23504, United States
Dominion Medical Associates
Richmond, Virginia, 23219, United States
Capital Clin Res Ctr,LLC
Olympia, Washington, 98502, United States
Wenatchee Valley Hospital and Clinics
Wenatchee, Washington, 98801-2028, United States
Liverpool Hospital
Liverpool, New South Wales, 2170, Australia
Royal Brisbane and Women's Hospital
Herston, Queensland, 4029, Australia
Core Research Centre
Milton, Queensland, 4064, Australia
South Australian Endocrine Research
Keswick, South Australia, 5035, Australia
Southern Adelaide Diabetes & Endocrine Services
Oaklands Park, South Australia, 5046, Australia
Barwon Health (The Geelong Hospital)
Geelong, Victoria, 3220, Australia
Fremantle Hospital
Fremantle, Western Australia, 6160, Australia
MHAT - Blagoevgrad AD, Department of Internal Diseases
Blagoevgrad, 2700, Bulgaria
Medical Center Zdrave Lom EOOD
Lom, 3600, Bulgaria
UMHAT Pulmed OOD - Pazardzhik, Department of Internal Diseases
Pazardzhik, 4400, Bulgaria
"MHAT - Pazardzhik"
Pazardzhik, 4401, Bulgaria
OCSOMCE - Dr. Albena Dinkova EOOD
Pleven, 5800, Bulgaria
UMHAT Kaspela EOOD, Endocrinology and Metabolic Diseases Clinic
Plovdiv, 4001, Bulgaria
MHAT Sveta Karidad EAD
Plovdiv, 4004, Bulgaria
MHAT Hadzhi Dimitar OOD
Sliven, 8800, Bulgaria
Medical center Smolyan clinical research OOD
Smolyan, 4700, Bulgaria
UMHAT "Aleksandrovska"
Sofia, 1431, Bulgaria
USHATE "Akad. Ivan Penchev" Second Clinic of Endocrinology
Sofia, 1431, Bulgaria
Medical Institute of Ministry of interior
Sofia, 1606, Bulgaria
UMHAT Sveta Marina EAD
Varna, 9010, Bulgaria
AIPSMC Dr. Artin Magardichyan EOOD
Varna, 9020, Bulgaria
MHAT- Hristo Botev AD
Vratsa, 3000, Bulgaria
MHAT- Hristo Botev
Vratsa, 3001, Bulgaria
MHAT Sveti Panteleimon - Yambol AD
Yambol, 8600, Bulgaria
LMC Clin Res Inc. Calgary
Calgary, Alberta, T2H 2G4, Canada
C-endo Diab Endo Clin Calgery
Calgary, Alberta, T2V 4J2, Canada
G.A. Research Associates Ltd.
Moncton, New Brunswick, E1G 1A7, Canada
LMC ClinRsrh Inc.Brampton
Brampton, Ontario, L6S 0C6, Canada
LMC Clinical Res Thornhill
Concord, Ontario, L4K 4M2, Canada
LMC Endo Ctr (Etobicoke) Ltd
Etobicoke, Ontario, M9R 4E1, Canada
Wharton Med Clin Trials
Hamilton, Ontario, L8L 5G8, Canada
LMC Research Inc. Ottawa
Nepean, Ontario, K2J 0V2, Canada
LMC Oakville
Oakville, Ontario, L6M 1M1, Canada
Stayner Medical Clinic
Stayner, Ontario, L0M 1S0, Canada
Winterberry Family Medicine
Stoney Creek, Ontario, L8J 0B6, Canada
LMC Endo Centres Ltd.(Bayview)
Toronto, Ontario, M4G 3E8, Canada
Mount Sinai Hospital
Toronto, Ontario, M5T 3L9, Canada
Applied Med Inf Res
Montreal, Quebec, H4A 3T2, Canada
LMC Clin Rsrch Inc. (Montreal)
Saint-Laurent, Quebec, H4T 1Z9, Canada
Poliklinika Solmed
Zagreb, City of Zagreb, 10000, Croatia
KBC Rijeka, Endokrinologija
Rijeka, Primorje-Gorski Kotar County, 51 000, Croatia
Opca bolnica Bjelovar
Bjelovar, 43000, Croatia
Klinicki bolnicki centar Osijek
Osijek, 31 000, Croatia
General Hospital Dr. Josip Bencevic_Diabetic department
Slavonski Brod, 35 000, Croatia
KB Dubrava, Zavod za endokrinologiju i dijabetes
Zagreb, 10000, Croatia
Klinicka bolnica Sveti Duh
Zagreb, 10000, Croatia
Ordinace pro choroby srdce
Chomutov, 430 02, Czechia
Diabetologická a endokrinologická ambulance Hlučín
Hlučín, 748 01, Czechia
Diahaza s.r.o.
Holešov, 76901, Czechia
Diahelp - diabetologie
Pardubice, 530 02, Czechia
DIALINE s.r.o.
Plzeň 3, 301 00, Czechia
Fakultni nemocnice Kralovske Vinohrady
Prague, 100 00, Czechia
DiaGolfova spol s.r.o.
Prague, 102 00, Czechia
Diabet2 s.r.o.
Prague, 110 00, Czechia
Diabetologická a endokrinologická ambulance Praha
Prague, 140 21, Czechia
Private Endocrnologist Dr Viitas
Pärnu, 80018, Estonia
East Tallinn Central Hospital
Tallinn, 10138, Estonia
Merelahe Family Doctors Centre
Tallinn, 10617, Estonia
Estonian Diabetes Centre
Tallinn, 13419, Estonia
Tartu University Hospital Internal Medicine Clinic
Tartu, 50406, Estonia
SA Viljandi Haigla
Viljandi, 71024, Estonia
Institut für Klinische Forschung und Entwicklung
Berlin, 10437, Germany
Plassmann
Essen, 45359, Germany
Zentrum für klinische Forschung, Dr. med. Lüdemann
Falkensee, 14612, Germany
Diabetes Zentrum Wandsbek Berufsausuebungsgemeinschaft GbR
Hamburg, 22041, Germany
Wendisch/Dahl Hamburg (DZHW)
Hamburg, 22607, Germany
Institut für Diabetesforschung GmbH Münster - Dr. med. Rose
Münster, 48145, Germany
RED-Institut für medizinische Forschung und Fortbildung GmbH
Oldenburg in Holstein, 23758, Germany
Praxis Dr. med. Wenzl-Bauer
Rehlingen-Siersburg, 66780, Germany
PTE-AOK II. Belgyogyaszati Klinika es Nephrologiai Centrum
Pécs, Baranya Vármegye, 7623, Hungary
Komáromi Selye János Kórház
Komárom, Komárom-Esztergom, 2900, Hungary
Óbudai Egészségügyi Centrum
Budapest, Pest County, 1036, Hungary
Szőcs Depot Egészségügyi Szolgáltató Kft.
Budapest, 1042, Hungary
Bajcsy-Zsilinszky Kórház
Budapest, 1106, Hungary
Dr. Vass László Egészségügyi Intézmény Diab. Szakrendelés
Budapest, 1152, Hungary
Debreceni Egyetem Klinikai Központ Belgyógyászati Klinika D épület
Debrecen, 4043, Hungary
Debreceni Egyetem Klinikai Központ Belgyógyászati Klinika
Debrecen, H-4032, Hungary
Tolna megyei Balassa János Kórház
Szekszárd, 7100, Hungary
Fejér Megyei Szent György Oktatókórház
Székesfehérvár, 8000, Hungary
Vas Vármegyei Markusovszky Egyetemi Oktatókórház
Szombathely, 9700, Hungary
Endolife Specialty Hospitals
Guntur, Andhra Pradesh, 522001, India
Care Outpatient Centre
Hyderabad, Andhra Pradesh, 500034, India
Kurnool Medical Collage
Kurnool, Andhra Pradesh, 518002, India
Nirmal Hospital Pvt. Ltd.
Surat, Gujarat, 395002, India
PGIMS Rohtak
Rohtak, Haryana, 124001, India
Ramaiah Memorial Hospital
Bangalore, Karnataka, 560054, India
Belgaum Diabetes Centre
Belagavi, Karnataka, 590001, India
KLES & Prabhakar Kore Hospital and Research Centre
Belagavi, Karnatka, 590010, India
Amrita Institute Of Medical Sciences & Research Centre
Kochi, Kerala, 682041, India
Seth GS medical college and KEM Hospital
Mumbai, Maharashtra, 400012, India
Apollo Hospital, Navi Mumbai
Mumbai, Maharashtra, 400614, India
Deenanath Mangeshkar Hospital & Research Centre
Pune, Maharashtra, 411004, India
Deenanath Mangeshkar Hospital and Research Centre
Pune, Maharashtra, 411004, India
Inamdar Multispeciality Hospital
Pune, Maharashtra, 411040, India
Fortis Hospital, Shalimar Bagh, New Delhi
New Delhi, National Capital Territory of Delhi, 110088, India
Apollo Hospital
Delhi, New Delhi, 110076, India
All India Institute of Medical Sciences
New Dehli, New Delhi, 110029, India
Dayanand Medical College & Hospital
Ludhiana, Punjab, 141001, India
Christian Medical College Hospital, Vellore
Vellore, Tamil Nadu, 632004, India
Gandhi Hospital & Medical college
Hyderabad, Telangana, 500003, India
Gleneagles Hospitals
Hyderabad, Telangana, 500004, India
Osmania General Hospital
Hyderabad, Telangana, 500012, India
MV Hospital and Research Centre
Lucknow, Uttar Pradesh, 226003, India
I.P.G.M.E & R Hospital
Kolkata, West Bengal, 700020, India
Apollo Multispeciality Hospital, Kolkata
Kolkata, West Bengal, 700054, India
NZOZ Przychodnia Specjalistyczna Medica
Lublin, Lubelski, 20-538, Poland
Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski
Gorzów Wielkopolski, Lubusz Voivodeship, 66-400, Poland
Uniwersytecki Szpital Kliniczny w Bialymstoku
Bialystok, Podlaskie Voivodeship, 15-276, Poland
NZOZ Specjalistyczny Osrodek Internistyczno-Diabetologiczny Małgorzata Arciszewska
Bialystok, Podlaskie Voivodeship, 15-435, Poland
Kresmed Sp. z o. o.
Bialystok, Podlaskie Voivodeship, 15-481, Poland
Centrum Zdrowia Metabolicznego
Poznan, Wielkopolskie Voivodeship, 60-589, Poland
Uniwersytecki Szpital Kliniczny w Bialymstoku
Bialystok, 15-276, Poland
Osteo Medic s.c. Artur Racewicz Jerzy Supronik
Bialystok, 15-351, Poland
SNZOZ Lege Artis
Bialystok, 15-404, Poland
Centrum Kliniczno Badawcze
Elblag, 82-300, Poland
Centrum Badan Klinicznych PI-House
Gdansk, 80-546, Poland
Uniwersyteckie Centrum Kliniczne im. prof. Gibinskiego, SUM
Katowice, 40-752, Poland
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie
Krakow, 30-688, Poland
Centrum Terapii Wspolczesnej J.M. Jasnorzewska S.K.A.
Lodz, 90-338, Poland
Gaja Poradnie Lekarskie
Poznan, 61-251, Poland
Centrum Medyczne "Diabetika"
Radom, 26-600, Poland
NBR Polska Tomasz Klodawski
Warsaw, 00-710, Poland
SP CSK Klinika Diabetologii i Chorob Wewnetrznych
Warsaw, 02-097, Poland
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych I Administracji
Warsaw, 02-507, Poland
Centrum Medyczne Oporow
Wroclaw, 52-416, Poland
Prywatny Gabinet Janusz Gumprecht
Zabrze, 41-800, Poland
Manati Ctr For Clin Research
Manatí, 00674, Puerto Rico
DIADA, s.r.o.
Bardejov, 08501, Slovakia
Diabetologicka ambulancia Diabetes care, s.r.o.
Hnúšťa, 98101, Slovakia
Diabetologicka ambulancia DIAMO s.r.o.
Kežmarok, 06001, Slovakia
MOMED, s.r.o
Kráľovský Chlmec, 077 01, Slovakia
IN-DIA s.r.o.
Lučenec, 984 01, Slovakia
Diabetologicka ambulancia MUDr. Alena Lomencikova, s.r.o
Martin, 036 01, Slovakia
DIABETOL, s.r.o.
Prešov, 080 01, Slovakia
OLIVER - MED s.r.o.
Rimavská Sobota, 979 01, Slovakia
MEDI-DIA s.r.o.
Sabinov, 08301, Slovakia
Diabetologicka ambulancia MUDr. Gabriela Zimova
Spišská Nová Ves, 052 01, Slovakia
General Hospital Celje
Celje, SI-3000, Slovenia
Healthcare Centre Koper
Koper, SI-6000, Slovenia
UKC Ljubljana, Endocrinology and Diabetes
Ljubljana, SI-1000, Slovenia
UKC Maribor - diabetes
Maribor, SI-2000, Slovenia
Healthcare Centre Nova Gorica
Nova Gorica, SI-5000, Slovenia
Taichung Veterans General Hospital
Taichung, 407, Taiwan
National Cheng Kung University Hospital
Tainan, 704, Taiwan
Related Publications (1)
Aroda VR, Aberle J, Bardtrum L, Christiansen E, Knop FK, Gabery S, Pedersen SD, Buse JB. Efficacy and safety of once-daily oral semaglutide 25 mg and 50 mg compared with 14 mg in adults with type 2 diabetes (PIONEER PLUS): a multicentre, randomised, phase 3b trial. Lancet. 2023 Aug 26;402(10403):693-704. doi: 10.1016/S0140-6736(23)01127-3. Epub 2023 Jun 26.
PMID: 37385279RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Clinical Reporting Office (2834)
- Organization
- Novo Nordisk A/S
Study Officials
- STUDY DIRECTOR
Clinical Transparency (dept. 1452)
Novo Nordisk A/S
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Masking Details
- Sponsor staff involved in the clinical trial is masked according to company standard procedures.
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 12, 2021
First Posted
January 13, 2021
Study Start
January 15, 2021
Primary Completion
March 7, 2023
Study Completion
March 8, 2023
Last Updated
December 9, 2025
Results First Posted
April 3, 2024
Record last verified: 2025-11
Data Sharing
- IPD Sharing
- Will share
According to the Novo Nordisk disclosure commitment on novonordisk-trials.com