Management of Acute Appendicitis at District General Hospital
1 other identifier
observational
200
1 country
1
Brief Summary
The Investigators aim to assess;
- 1.whether the changes in managing patients during COVID has reduced the negative appendicectomy rate?
- 2.compare the difference in outcomes of conservatively and surgically managed Acute Appendicitis?
- 3.Whether there uniformity in prescribing postoperative antibiotics with resultant outcomes?
- 4.Whether the incidence of complicated appendicitis has increased?
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2020
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 30, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 31, 2020
CompletedFirst Submitted
Initial submission to the registry
January 11, 2021
CompletedFirst Posted
Study publicly available on registry
January 13, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
January 30, 2021
CompletedJanuary 14, 2021
January 1, 2021
9 months
January 11, 2021
January 12, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
Negative Appendicectomy Rate
Negative appendicectomy rate will be calculated to define the benefits of increasing the preoperative scanning in the form of ultrasound, CT scan or both.
8 months
Outcomes of Conservative vs Operative Management
The outcomes of both conservatively and operatively managed patients will be assessed to define the best management approach.
8 months
Increased Open Appendicectomy Rate
The rate of laparoscopic to open and open appendicectomy rate will be calculated to understand if the surgical practice has been changed during COVID-19 pandemic?
8 months
Surgical site infection in patients on antibiotics
The rate of incidence of superficial and deep wound infection will be calculated to define the applicability of use of Antibiotics
8 months
Secondary Outcomes (1)
Length of Stay
8 months
Study Arms (2)
Acute Appendicitis pre-COVID management
Audit of Acute appendicitis management in 2017-18
Acute Appendicitis during COVID management
Audit of Acute appendicitis management in 2020
Interventions
Laparoscopic or Open Appendicectomy
Eligibility Criteria
All patients with a diagnosis of Acute Appendicitis will be included
You may qualify if:
- All participants reporting in accident and emergency with a diagnosis of acute appendicitis irrespective of age above 5 years, gender and morbidities (this group for conservative management)
You may not qualify if:
- None
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
The Princess Alexandra Hospital NHS Trust
Harlow, Essex, CM20 1EL, United Kingdom
Related Publications (5)
Hori T, Machimoto T, Kadokawa Y, Hata T, Ito T, Kato S, Yasukawa D, Aisu Y, Kimura Y, Sasaki M, Takamatsu Y, Kitano T, Hisamori S, Yoshimura T. Laparoscopic appendectomy for acute appendicitis: How to discourage surgeons using inadequate therapy. World J Gastroenterol. 2017 Aug 28;23(32):5849-5859. doi: 10.3748/wjg.v23.i32.5849.
PMID: 28932077BACKGROUNDvan den Boom AL, de Wijkerslooth EML, van Rosmalen J, Beverdam FH, Boerma EG, Boermeester MA, Bosmans JWAM, Burghgraef TA, Consten ECJ, Dawson I, Dekker JWT, Emous M, van Geloven AAW, Go PMNYH, Heijnen LA, Huisman SA, Jean Pierre D, de Jonge J, Kloeze JH, Koopmanschap MA, Langeveld HR, Luyer MDP, Melles DC, Mouton JW, van der Ploeg APT, Poelmann FB, Ponten JEH, van Rossem CC, Schreurs WH, Shapiro J, Steenvoorde P, Toorenvliet BR, Verhelst J, Versteegh HP, Wijnen RMH, Wijnhoven BPL. Two versus five days of antibiotics after appendectomy for complex acute appendicitis (APPIC): study protocol for a randomized controlled trial. Trials. 2018 May 2;19(1):263. doi: 10.1186/s13063-018-2629-0.
PMID: 29720238BACKGROUNDFerguson DM, Parker TD, Arshad SA, Garcia EI, Hebballi NB, Tsao K. Standardized Discharge Antibiotics May Reduce Readmissions in Pediatric Perforated Appendicitis. J Surg Res. 2020 Nov;255:388-395. doi: 10.1016/j.jss.2020.05.086. Epub 2020 Jun 29.
PMID: 32615311BACKGROUNDJavanmard-Emamghissi H, Boyd-Carson H, Hollyman M, Doleman B, Adiamah A, Lund JN, Clifford R, Dickerson L, Richards S, Pearce L, Cornish J, Hare S, Lockwood S, Moug SJ, Tierney GM; COVID: HAREM (Had Appendicitis, Resolved/Recurred Emergency Morbidity/Mortality) Collaborators Group. The management of adult appendicitis during the COVID-19 pandemic: an interim analysis of a UK cohort study. Tech Coloproctol. 2021 Apr;25(4):401-411. doi: 10.1007/s10151-020-02297-4. Epub 2020 Jul 15.
PMID: 32671661BACKGROUNDRIFT Study Group on behalf of the West Midlands Research Collaborative. Appendicitis risk prediction models in children presenting with right iliac fossa pain (RIFT study): a prospective, multicentre validation study. Lancet Child Adolesc Health. 2020 Apr;4(4):271-280. doi: 10.1016/S2352-4642(20)30006-7. Epub 2020 Feb 13.
PMID: 32200936BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Naveed Kirmani, FRCS
The Princess Alexandra Hospital NHS Trust
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
January 11, 2021
First Posted
January 13, 2021
Study Start
January 30, 2020
Primary Completion
October 31, 2020
Study Completion
January 30, 2021
Last Updated
January 14, 2021
Record last verified: 2021-01
Data Sharing
- IPD Sharing
- Will not share