Efficacy of Ketamine in Post Anesthesia Recovery Room

NCT04701008 | Completed

• 1 other identifier: Pro00102967
• Study Type: observational
• Target: 143
• Locations: 1 country
• Sites: 1

Brief Summary

Observational study to assess efficacy of IV ketamine bolus when used in the post anesthesia recovery unit for uncontrolled pain despite use of opioids.

Conditions

Pain, Postoperative; Ketamine Adverse Reaction; Pain, Refractory; Pain, Intractable; Pain, Acute

Keywords

pain score reduction; reduction in pain scores; post-operative pain; ketamine use in recovery room; recovery room; ketamine recovery; ketamine rescue

Outcome Measures

Primary Outcomes (1)

• Reduction in pain score after ketamine use in PACU

  The Numeric Rating Scale (NRS-11) is an 11-point scale for patient self-reporting of pain. It is what is used most often in our recovery room for pain assessment. A score of 0/10 means no pain, and 10/10 means worst pain.

  in the immediate post-operative period in recovery room

Secondary Outcomes (1)

• Incidence of side effects after ketamine use

  in the immediate post-operative period in recovery room

Study Arms (1)

Patients with significative post-operative pain despite

Patients with significant pain despite receiving narcotics in PACU will receive a bolus dose of IV ketamine to assess its efficacy for pain score reduction. Bolus doses are given by 10mg IV increments, to reach approximate dose of 0,25mg/kg.

Drug: Ketamine

Interventions

Ketamine DRUG

IV ketamine - 10mg bolus may be repeated repeated 2-3 times depending on clinical judgement

Patients with significative post-operative pain despite

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The following patients will be identified and recruited at the post-anesthesia care unit: Adult patients undergoing non-cardiac surgery at University of Alberta Hospital meeting the following criteria: 1. age ≥ 18 2. significant pain despite narcotics used in post anesthesia care unit 3. ketamine ordered by attending anesthesiologist

You may qualify if:

• Adult patients undergoing non cardiac surgery at University of Alberta Hospital meeting the following criteria:
• age ≥ 18
• significant pain despite narcotics used in post-anesthesia care unit
• ketamine ordered by attending anesthesiologist

You may not qualify if:

• Patient refusal to receive ketamine
• Patients undergoing cardiac surgery
• Patients who received no narcotics
• Contra-indication to receiving ketamine (determined by attending anesthesiologist)

Sponsors & Collaborators

• University of Alberta: lead

Study Sites (1)

University of Alberta Hospital

Edmonton, Alberta, t6g2b7, Canada

Location

Related Publications (3)

• Brinck EC, Tiippana E, Heesen M, Bell RF, Straube S, Moore RA, Kontinen V. Perioperative intravenous ketamine for acute postoperative pain in adults. Cochrane Database Syst Rev. 2018 Dec 20;12(12):CD012033. doi: 10.1002/14651858.CD012033.pub4.

  PMID: 30570761 BACKGROUND

• Gillies A, Lindholm D, Angliss M, Orr A. The use of ketamine as rescue analgesia in the recovery room following morphine administration--a double-blind randomised controlled trial in postoperative patients. Anaesth Intensive Care. 2007 Apr;35(2):199-203.

  PMID: 17444308 BACKGROUND

• Weinbroum AA. A single small dose of postoperative ketamine provides rapid and sustained improvement in morphine analgesia in the presence of morphine-resistant pain. Anesth Analg. 2003 Mar;96(3):789-795. doi: 10.1213/01.ANE.0000048088.17761.B4.

  PMID: 12598264 BACKGROUND

MeSH Terms

Conditions

Pain, Postoperative; Pain, Intractable; Acute Pain

Interventions

Ketamine

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Cyclohexanes; Cycloparaffins; Hydrocarbons, Alicyclic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 5, 2021
• First Posted: January 8, 2021
• Study Start: September 1, 2020
• Primary Completion: May 28, 2021
• Study Completion: May 28, 2021
• Last Updated: September 19, 2024

Record last verified: 2022-07

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)