Electrocardiographic QRS Axis Shift ,Rotation and COVİD-19

NCT04698083 | Completed

• 1 other identifier: 22/7/2020-2152
• Study Type: observational
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

In patients with coronavirus disease (COVID-19), severe dyspnea is the most dramatic complication.Severe respiratory difficulties may include electrocardiographic frontal QRS axis rightward shift (Rws) and clockwise rotation (Cwr). This study investigated the predictability of advanced lung tomography findings with QRS axis shift and rotation. This was a retrospective analysis of 160 patients.The patients were divided into two groups: normal oxygen saturation(SpO2) (NS; n = 80) and low SpO2(LS;n = 80).They were then divided into NS Rws (n = 37), NS leftward shift (Lws; n = 43), LS Rws (n = 40), and LS Lws (n = 40) according to electrocardiographic follow-up findings. These groups were compared in terms of electrocardiographic rotation (Cwr, counterclockwise rotation, or normal transition), tomographic stage (CO-RADS5(advanced)/CO-RADS1-4), electrocardiographic intervals, and laboratory findings

Conditions

Covid19

Outcome Measures

Primary Outcomes (3)

• Differences in the electrocardiographic QRS axis shift(°),

  Differences in the axis shift between the Rws and Lws groups in patients with NS /LS groups.

  10-15 days

• Differences in the electrocardiographic rotation

  Differences in clockwise,counterclockwise,normal transition between the groups.

  10-15 days

• Differences in the CO-RADS5/CO-RADS1-4 ratio

  Differences in the CO-RADS5/CO-RADS1-4 ratio between the groups.

  10-15 days

Study Arms (2)

Group1:normal SpO2(NS,n = 80) and low SpO2(LS, n = 80).

Patients with normal oxygen saturation (SpO2; ≥ 90%) who did not receive oxygen therapy and patients with low SpO2(\<90%) who received nasal oxygen therapy were included in this study

Diagnostic Test: Electrocardiography ,Tomographic imaging

Group2:Rightward axis shift(Rws) and Leftward axis shift (Lws)

Both groups were divided into two main subgroups:patients with Rws and patients with leftward shift(Lws) of the QRS axis.The patient numbers were as follows: NS Rws (n=37),NS Lws(n=43),LS Rws (n=40),andLS Lws (n=40)

Diagnostic Test: Electrocardiography ,Tomographic imaging

Interventions

Electrocardiography ,Tomographic imaging DIAGNOSTIC_TEST

Based on electrocardiographic follow-up analyses,the two main groups were compared in terms of rotation condition (i.e., Cwr, normal transition, or CCwr), electrocardiographic intervals, and laboratory findings In our study,CO-RADS5 was considered an advanced tomographic finding(e.g., multifocal ground glass opacities with consolidation, vascular thickening,crazy paving pattern,mixed pattern),while CO-RADS1,2,3, and 4 were considered non-advanced tomographic findings.

Group1:normal SpO2(NS,n = 80) and low SpO2(LS, n = 80).; Group2:Rightward axis shift(Rws) and Leftward axis shift (Lws)

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hospitalized patients with dyspnea and COVID-19

You may qualify if:

• Hospitalized patients with dyspnea and COVID-19

You may not qualify if:

• Patients who received positive pressurized oxygen therapy Patients who underwent mechanical ventilation, Atrial fibrillation Complete bundle branch block Significant arrhythmias(complete atrioventricular block, polymorphic ventricular tachycardia, and ventricular fibrillation), Wolff-Parkinson-White syndrome, supraventricular tachycardia Unclear QRS axis orientation.

Sponsors & Collaborators

• Ankara Education and Research Hospital: lead

Study Sites (1)

Şahbender Koç

Ankara, 06530, Turkey (Türkiye)

Location

Related Publications (1)

• Koc S, Bozkaya VO, Yikilgan AB. Electrocardiographic QRS axis shift, rotation and COVID-19. Niger J Clin Pract. 2022 Apr;25(4):415-424. doi: 10.4103/njcp.njcp_9_21.

  PMID: 35439899 DERIVED

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Şahbender Koç

  University of Health Sciences Ankara Keçiören Education Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Cardıologist

Study Record Dates

• First Submitted: January 4, 2021
• First Posted: January 6, 2021
• Study Start: July 22, 2020
• Primary Completion: October 15, 2020
• Study Completion: November 5, 2020
• Last Updated: January 6, 2021

Record last verified: 2021-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)