NCT04697784

Brief Summary

The purpose of this study is to determine the long-term performance of the TREO Abdominal Stent-Graft as a treatment for patients with Infrarenal Abdominal Aortic Aneurysms or Aorto-iliac Aneurysms.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
338

participants targeted

Target at P75+ for not_applicable

Timeline
15mo left

Started Jan 2021

Longer than P75 for not_applicable

Geographic Reach
1 country

40 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress81%
Jan 2021Jul 2027

First Submitted

Initial submission to the registry

December 10, 2020

Completed
27 days until next milestone

First Posted

Study publicly available on registry

January 6, 2021

Completed
14 days until next milestone

Study Start

First participant enrolled

January 20, 2021

Completed
6.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 31, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 31, 2027

Last Updated

June 26, 2025

Status Verified

June 1, 2025

Enrollment Period

6.5 years

First QC Date

December 10, 2020

Last Update Submit

June 23, 2025

Conditions

Keywords

AAAAbdominal Aortic AneurysmTREOEVAR

Outcome Measures

Primary Outcomes (2)

  • Incidence of stent-strut fracture or barb separation as confirmed by the Imaging Core Laboratory.

    Incidence of fracture in a stent-strut or separation of one or more proximal fixation barbs as confirmed by the Imaging Core Laboratory upon review of post-implant imaging studies.

    Through 5 Years post-procedure

  • Incidence of secondary intervention for adverse events related to or caused as a result of stent-strut fracture or barb separation.

    Incidence of secondary intervention for adverse events related to or caused as a result of a fracture in a stent-strut or separation of one or more proximal fixation barbs. Relatedness to the device will be confirmed by the Clinical Events Committee (CEC) through review of available treatment and procedure records and reports of imaging studies.

    Through 5 Years post-procedure

Secondary Outcomes (16)

  • Number of participants with technical success at the conclusion of the index procedure

    Through 5 Years post-procedure

  • Major Adverse Events

    Through 5 Years post-procedure

  • Incidence of procedure-related clinical utility measures

    Through 5 Years post-procedure

  • Incidence of procedure-related complications

    Through 5 Years post-procedure

  • Incidence of successful aneurysm treatment

    12 months post-implant

  • +11 more secondary outcomes

Study Arms (1)

Subjects who receive the TREO Abdominal Stent-Graft System

EXPERIMENTAL

Eligible subjects will be implanted with the TREO Abdominal Stent-Graft System.

Device: TREO Abdominal Stent-Graft System

Interventions

The TREO Abdominal Stent-Graft System is intended for the treatment of infrarenal abdominal aortic aneurysms with or without iliac involvement.

Subjects who receive the TREO Abdominal Stent-Graft System

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Willing and able to comply with all study procedures and visits.
  • Written informed consent to participate in the study.
  • Patient's aneurysm can be treated with the TREO Abdominal Stent-Graft System.
  • Adequate data (medical records/imaging studies) available to analyze the primary endpoints for patients enrolled retrospectively.

You may not qualify if:

  • Medical, social or psychological problems that, in the opinion of the investigator, preclude patient from receiving treatment with the TREO Abdominal Stent-Graft System.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (40)

Vascular Surgery Specialists

Phoenix, Arizona, 85006, United States

Location

Pima Heart and Vascular

Tucson, Arizona, 85718, United States

Location

University of California, San Francisco-Fresno

Fresno, California, 93701, United States

Location

University of California, San Diego

La Jolla, California, 92037, United States

Location

VA San Diego

San Diego, California, 92161, United States

Location

University of Colorado Anschutz

Aurora, Colorado, 80045, United States

Location

Yale University

New Haven, Connecticut, 06520, United States

Location

Medstar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States

Location

Malcom Randall VA Medical Center

Gainesville, Florida, 32608, United States

Location

University of Florida

Gainesville, Florida, 32610, United States

Location

Coastal Vascular and Interventional

Pensacola, Florida, 32504, United States

Location

University of South Florida / Tampa General Hospital

Tampa, Florida, 33606, United States

Location

Piedmont Heart Institute

Atlanta, Georgia, 30309, United States

Location

Northside Hospital

Atlanta, Georgia, 30342, United States

Location

University of Iowa Hospital and Clinic

Iowa City, Iowa, 52242, United States

Location

Tufts Medical Center

Boston, Massachusetts, 02111, United States

Location

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Location

McLaren Bay Region

Bay City, Michigan, 48708, United States

Location

Henry Ford Hospital

Detroit, Michigan, 48202, United States

Location

Minneapolis Heart Institute Foundation

Minneapolis, Minnesota, 55407, United States

Location

Barnes Jewish Hospital at Washington University

St Louis, Missouri, 63110, United States

Location

Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States

Location

Rutgers Robert Wood Johnson Medical Center

New Brunswick, New Jersey, 08901, United States

Location

Lenox Hill Hospital / Northwell Health

New York, New York, 10075, United States

Location

Stony Brook Medical Center

Stony Brook, New York, 11794-8191, United States

Location

SUNY Upstate Medical University

Syracuse, New York, 13210, United States

Location

Montefiore Medical Center

The Bronx, New York, 10467, United States

Location

Mission Health

Asheville, North Carolina, 27607, United States

Location

East Carolina University

Greenville, North Carolina, 27834, United States

Location

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States

Location

Oregon Health and Science University

Portland, Oregon, 97239, United States

Location

VA Portland Healthcare System

Portland, Oregon, 97239, United States

Location

Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States

Location

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15232, United States

Location

Wellmont Cardiology Services

Kingsport, Tennessee, 37660, United States

Location

St. David's Healthcare (Cardiothoracic and Vascular Surgeons)

Austin, Texas, 78756, United States

Location

University of Utah Hospital

Salt Lake City, Utah, 84132, United States

Location

Sentara Heart Hospital

Norfolk, Virginia, 22042, United States

Location

Virginia Commonwealth University

Richmond, Virginia, 23282, United States

Location

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

Location

MeSH Terms

Conditions

Aortic Aneurysm, Abdominal

Condition Hierarchy (Ancestors)

Aortic AneurysmAneurysmVascular DiseasesCardiovascular DiseasesAortic Diseases

Study Officials

  • Gretchen Wild

    Terumo Aortic

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Model Details: Abdominal Aortic Aneurysm Stent-Graft
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 10, 2020

First Posted

January 6, 2021

Study Start

January 20, 2021

Primary Completion (Estimated)

July 31, 2027

Study Completion (Estimated)

July 31, 2027

Last Updated

June 26, 2025

Record last verified: 2025-06

Data Sharing

IPD Sharing
Will not share

Locations