NCT04684160

Brief Summary

Comparison of postoperative patient's joint awareness as well as clinical and radiological outcomes between fixed- and mobile-bearing total knee arthroplasty of which the prosthesis is coated with Titanium-nitride.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Oct 2016

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 19, 2016

Completed
4.2 years until next milestone

First Submitted

Initial submission to the registry

December 16, 2020

Completed
8 days until next milestone

First Posted

Study publicly available on registry

December 24, 2020

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2022

Completed
Last Updated

December 24, 2020

Status Verified

December 1, 2020

Enrollment Period

6.2 years

First QC Date

December 16, 2020

Last Update Submit

December 21, 2020

Conditions

Outcome Measures

Primary Outcomes (2)

  • Forgotten joint score

    Questionnaire of evaluating how much the patients are aware of their operate joint during daily activities. The higher, the worse. Range: 0-100

    Postoperative 3 years

  • Crepitus

    Any grating, crackling or popping sensation around knee when moving a joint

    Postoperative 3 years

Secondary Outcomes (2)

  • Forgotten joint score

    Postoperative 5 years

  • Crepitus

    Postoperative 5 years

Other Outcomes (6)

  • Change from baseline Knee Society Score (KSS) at 3 and 5 years

    Preoperative and Postoperative 3, 5 years

  • Change from baseline Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at 3 and 5 years

    Preoperative and Postoperative 3, 5 years

  • Central Sensitization Index (CSI)

    Postoperative 3 years

  • +3 more other outcomes

Study Arms (2)

Fixed-bearing group

ACTIVE COMPARATOR
Device: Fixed-bearing TKA

Mobile-bearing group

EXPERIMENTAL
Device: Mobile-bearing TKA

Interventions

Fixed-bearing group
Mobile-bearing group

Eligibility Criteria

Age55 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Diagnosed with knee joint advanced osteoarthritis
  • Age over 55 years old
  • Scheduled to undergo primary total knee arthroplasty

You may not qualify if:

  • Post-traumatic or inflammatory osteoarthritis
  • Those who undertook previous ligamentous surgery
  • Those who do not understand and give answers to a survey

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The Catholic University of Korea Seoul St Mary's hospital

Seoul, South Korea

Location

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

OsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Study Officials

  • Yong In, M.D., Ph.D.

    Seoul St. Mary's Hospital

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

December 16, 2020

First Posted

December 24, 2020

Study Start

October 19, 2016

Primary Completion

December 31, 2022

Study Completion

December 31, 2022

Last Updated

December 24, 2020

Record last verified: 2020-12

Data Sharing

IPD Sharing
Will not share

Locations