tDCS, Moral Decision-Making, fMRI

NCT04681391 | Completed

• 1 other identifier: 2016B008
• Study Type: observational
• Target: 42
• Locations: 0 countries
• Sites: N/A

Brief Summary

Morality is the social rule about appropriateness of the behavior, containing concepts of justice, fairness, and rights. Previous studies suggested that the activation of right temporoparietal junction (rTPJ) should be involved in mental state reasoning in moral cognition. Implicit moral attitude, which reflects people's fundamental beliefs about right and wrong, could be assessed by implicit association test on moral scenarios (mIAT), as indicated by the D scores. According to our previous findings, we postulate that, during moral decision-making, the high D group would have less rTPJ involvement and the low D group would have more. Here we applied tDCS, a non-invasive neuromodulation technique, to modulate cortical excitability in rTPJ. Based on our postulation, we divided participants into high D and low D group and hypothesized that tDCS over rTPJ would modulate the behavior depending on the group. The results revealed that, in aspect of mIAT, implicit moral attitude could be modulated differently depending on the group via tDCS over rTPJ. In addition, hemodynamic response within rTPJ showed a main effect of tDCS while carrying out the helping behavior. In conclusion, these findings indicated that tDCS over rTPJ could modulate the implicit moral attitude as well as the rTPJ activity during moral action.

Conditions

Morality

Keywords

tDCS, Moral Decision-Making, Implicit Attitude, fMRI

Outcome Measures

Primary Outcomes (3)

• Justice Sensitivity Inventory

  Justice Sensitivity Inventory (JSI) is a self-report questionnaire which consists of four perspectives of justice sensitivity: victim, observer, beneficiary, and perpetrator (Schmitt, Baumert, Gollwitzer, \& Maes, 2010; Schmitt, Gollwitzer, Maes, \& Arbach, 2005). Each perspective contains ten descriptions, and participants would answer on a scale ranging from 1 (not at all) to 7 (exactly). Justice sensitivity reflects how people react to injustice and can be used to predict justice-related emotion and behavior (Baumert, Rothmund, Thomas, Gollwitzer, \& Schmitt, 2013).

  10 minutes

• Morality Implicit Association Test

  Implicit moral attitude was assessed by morality implicit association test (mIAT) in present study. The test was adapted from Implicit Association Test (IAT) developed by Greenwald and colleagues (1998). It measures the strength of the association 10 between target concepts and their associated attributes. In mIAT, target concepts were presented by morally good and morally bad clips, and attributes were presented by positive and negative words.

  15 minutes

• Moral Action Task

  To verify the modulation of rTPJ activity via tDCS and to examine whether this modulation would alter people's moral behavior, participants would take the perspective of the active role while viewing moral scenarios in the MRI scanner. Forty-five dynamic visual stimuli from previous research were validated and applied in the Moral Action Task. Each animation consists of three still images with the respective duration of 1000ms, 200ms, and 200ms. These animations contain three kinds of moral scenarios: (1) a person who is taking an action to physically harm one another (perpetrating behavior); (2) a person who is alleviating the physical pain which the other one is suffered (helping behavior); and (3) a person who is carrying out an action that irrelevant to the other one (neural behavior). Additionally, the protagonists in these scenarios were all acting without the presence of faces, and therefore the participants would have no emotional clues for these social interactions.

  10 minutes

Secondary Outcomes (1)

• Moral Evaluation: Rating of Moral Action Task

  5 minutes

Study Arms (3)

anodal

For the active stimulation, which are anodal and cathodal tDCS, a constant current of 1 mA was delivered through 35 cm2 electrode for 20 minutes with fade-in and fade-out of 10 seconds, producing a current density of 0.029 mA/cm2. During anodal tDCS, the anode was placed over right temporoparietal junction, and the cathode was placed over left supraorbital area.

Device: transCranial direct current stimulation

cathodal

For the active stimulation, which are anodal and cathodal tDCS, a constant current of 1 mA was delivered through 35 cm2 electrode for 20 minutes with fade-in and fade-out of 10 seconds, producing a current density of 0.029 mA/cm2. During cathodal tDCS, the cathode was placed over right temporoparietal junction, and the anode was placed over left supraorbital area.

Device: transCranial direct current stimulation

sham (as a control condition)

same fade-in, fade-out, and current density were applied for the sham stimulation, but the duration of current-delivering only last 35 seconds.

Device: transCranial direct current stimulation

Interventions

transCranial direct current stimulation DEVICE

In the present study, we applied DC Brain Stimulator Plus to stimulate right temporoparietal junction (rTPJ). The target electrode was placed over the location of rTPJ; on the other hand, the return electrode was placed over the left supraorbital area. That is, during anodal tDCS, the anode was placed over CP6, and the cathode was placed over left supraorbital area; conversely, during cathodal tDCS, the cathode was placed over CP6, and the anode was placed over left supraorbital area. For the active stimulation, which are anodal and cathodal tDCS, a constant current of 1 mA was delivered through 35 cm2 electrode for 20 minutes with fade-in and fade-out of 10 seconds, producing a current density of 0.029 mA/cm2. On the other hand, same fade-in, fade-out, and current density were applied for the sham stimulation, but the duration of current-delivering only last 35 seconds. Therefore, participants could feel the skin sensation but did not have the after-effects of tDCS.

anodal; cathodal; sham (as a control condition)

Eligibility Criteria

• Age: 20 Years - 30 Years
• Sex: all
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Forty-two healthy volunteers (20 male; 22 female) without any history of psychiatry or neurological disorders (e.g., dementia, seizures), head injury, and alcohol or substance abuse, are all ethnic Chinese, right-handed, and aged between 20 to 30 years old (M = 23.476, SD = 2.211). They were recruited via the online survey sent to the student social group of National Yang-Ming University and National Taiwan University. Additionally, the study was approved by National Yang-Ming University Hospital, Yilan, Taiwan (IRB: 2016B008).

You may qualify if:

• healthy volunteers, are all ethnic Chinese, right-handed, and aged between 20 to 30 years old

You may not qualify if:

• any history of psychiatry or neurological disorders (e.g., dementia, seizures), head injury, and alcohol or substance abuse

Sponsors & Collaborators

• National Yang Ming Chiao Tung University Hospital: lead

Related Publications (6)

• Ciaramelli E, Muccioli M, Ladavas E, di Pellegrino G. Selective deficit in personal moral judgment following damage to ventromedial prefrontal cortex. Soc Cogn Affect Neurosci. 2007 Jun;2(2):84-92. doi: 10.1093/scan/nsm001.

  PMID: 18985127 BACKGROUND

• FeldmanHall O, Mobbs D, Evans D, Hiscox L, Navrady L, Dalgleish T. What we say and what we do: the relationship between real and hypothetical moral choices. Cognition. 2012 Jun;123(3):434-41. doi: 10.1016/j.cognition.2012.02.001. Epub 2012 Mar 9.

  PMID: 22405924 BACKGROUND

• Fumagalli M, Priori A. Functional and clinical neuroanatomy of morality. Brain. 2012 Jul;135(Pt 7):2006-21. doi: 10.1093/brain/awr334. Epub 2012 Feb 13.

  PMID: 22334584 BACKGROUND

• Nitsche MA, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol. 2000 Sep 15;527 Pt 3(Pt 3):633-9. doi: 10.1111/j.1469-7793.2000.t01-1-00633.x.

  PMID: 10990547 BACKGROUND

• Gaesser B, Hirschfeld-Kroen J, Wasserman EA, Horn M, Young L. A role for the medial temporal lobe subsystem in guiding prosociality: the effect of episodic processes on willingness to help others. Soc Cogn Affect Neurosci. 2019 May 17;14(4):397-410. doi: 10.1093/scan/nsz014.

  PMID: 30809675 RESULT

• Santiesteban I, Banissy MJ, Catmur C, Bird G. Enhancing social ability by stimulating right temporoparietal junction. Curr Biol. 2012 Dec 4;22(23):2274-7. doi: 10.1016/j.cub.2012.10.018. Epub 2012 Nov 1.

  PMID: 23122848 RESULT

MeSH Terms

Interventions

Transcranial Direct Current Stimulation

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 18, 2020
• First Posted: December 23, 2020
• Study Start: December 27, 2016
• Primary Completion: November 30, 2019
• Study Completion: December 10, 2020
• Last Updated: December 23, 2020

Record last verified: 2020-12