Lung Ultrasound to Assess Aeration Loss After Lung Resection Surgery

NCT04677309 | Completed

• 1 other identifier: THORUS
• Study Type: observational
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this prospective observational study is to assess perioperative changes in lung aeration after lung resection surgery using lung ultrasound, and to explore their relationship with oxygenation, inflammatory biomarkers, cardiac stress markers and diaphragmatic function.

Conditions

Lung Neoplasm; Lung Cancer; Lung Resection Surgery; Thoracic Surgery; One-lung Ventilation (OLV); Postoperative Pulmonary Complications (PPCs); Lung Ultrasound; Lung Ultrasound Score

Keywords

thoracic surgery; lung ultrasound; lung aeration; lung ultrasound score; lung resection; lobectomy; one-lung ventilation; postoperative pulmonary complications; oxygenation; cytokines; NT-proBNP; diaphragmatic function

Outcome Measures

Primary Outcomes (1)

• Change in lung aeration after lung resection surgery assessed by lung ultrasound score

  The lung ultrasound score is a semiquantitative score used to assess lung aeration. Higher values indicate greater loss of aeration. Changes will be assessed between the preoperative period, the immediate postoperative period after extubation, and 24 hours after surgery.

  preoperative vs immediate postoperative period vs 24 hours after surgery

Secondary Outcomes (5)

• Regional distribution of lung ultrasound findings in the operated and non-operated lung

  preoperative vs immediate postoperative period vs 24 hours after surgery

• Changes in oxygenation after lung resection surgery

  preoperative vs immediate postoperative vs 24 hours after surgery

• Changes in plasma inflammatory biomarkers after lung resection surgery

  preoperative vs immediate postoperative vs 24 hours after surgery

• Changes in cardiac stress markers after lung resection surgery

  preoperative vs immediate postoperative vs 24 hours after surgery

• Changes in diaphragmatic function after lung resection surgery

  preoperative vs immediate postoperative vs 24 hours after surgery

Study Arms (1)

Lung resection surgery

Adult patients scheduled for elective lobectomy surgery under one-lung ventilation in a tertiary referral hospital.

Diagnostic Test: Perioperative lung ultrasound assessment

Interventions

Perioperative lung ultrasound assessment DIAGNOSTIC_TEST

Lung ultrasound was performed at three predefined perioperative time points: before surgery, in the immediate postoperative period after extubation, and 24 hours after surgery. Each hemithorax was assessed in six regions, and lung aeration was evaluated using a semiquantitative lung ultrasound score.

Lung resection surgery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients scheduled for elective lung resection surgery at a tertiary referral hospital.

You may qualify if:

• Age \> 18
• ASA I-III
• Non-small cell lung neoplasm
• Elective lobectomy
• Under one-lung ventilation

You may not qualify if:

• pregnancy
• Diagnosed pulmonary fibrosis
• Scheduled surgery limited to biopsy
• Surgery that includes resection of the thoracic wall or the diaphragm
• Predicted FEV1 \< 40%
• Neoplasm metastasis
• Obesity class II or more (BMI ≥ 35 kg/m\^2)
• Risk of malnutrition CONUT score \> 1
• Hemoglobin \< 10 g/dl
• Chronic kidney failure: glomerular filtration \< 60 ml/min/m\^2, nephrectomy, kidney transplantation
• Treatment with corticosteroids or immunosuppressive agents 3 months before surgery
• Transfusion of blood products during the previous 10 days
• Heart failure (New York Heart Association Functional Class 3 or 4) during the week before surgery.
• Heart valve diseases over stage B of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines 2014
• Previously documented elevated left atrial pressure or cardiac disease associated with elevated left-sided filling pressures.

Sponsors & Collaborators

• Ana Broseta Lleó: lead
• Hospital General Universitario de Valencia: collaborator

Study Sites (1)

Hospital General Universitario de Valencia

Valencia, Valencia, 46014, Spain

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Whole blood and plasma samples

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Ana Broseta Lleó, Consultant

  Hospital General Universitario de Valencia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Consultant in Anesthesiology

Study Record Dates

• First Submitted: November 24, 2020
• First Posted: December 21, 2020
• Study Start: December 20, 2020
• Primary Completion: January 30, 2022
• Study Completion: April 30, 2022
• Last Updated: June 18, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)