Treatment of Mirizzi Syndrome

NCT04672902 | Completed

• 1 other identifier: MS2012
• Study Type: observational
• Target: 3
• Locations: 1 country
• Sites: 1

Brief Summary

Mirizzi syndrome is an infrequent complication of long-standing cholelithiasis. Extrinsic compression of the common hepatic duct is usually caused by an impacted stone in Hartmann's pouch or cystic duct resulting in the development of cholecystobiliary fistula. This syndrome is classified based on the presence and severity of cholecystobiliary fistula. Mirizzi syndrome is challenging to diagnose preoperatively and may require complex biliary surgical procedures for resolution. Endoscopic treatment is a safe alternative with a high success rate. Single-operator cholangioscopy combined with lithotripsy has been shown to have a 90-100% success rate in the treatment of biliary stones. Herein, A single center experience treating Mirizzi syndrome with single-operator cholangioscopy guided electrohydraulic lithotripsy is presented. Difficult management of Mirizzi syndrome has led to research of new treatment options to minimize the risk of high rate complications. Single-operator cholangioscopy in combination with laser lithotripsy is an adequate and safe alternative for the treatment of this condition.

Conditions

Mirizzi Syndrome; Cholelithiasis; Acute Cholecystitis

Outcome Measures

Primary Outcomes (1)

• Resolution of the common bile duct compression by an extrinsic gallbladder stone, with minimally invasive procedure such as single operator cholangioscopy, combined with lithotripsy

  Single operator cholangioscopy, combined with lithotripsy, will be use for treating patients with Mirizzi syndrome, while avoiding open surgery, and subsequent lesions to the biliary ducts. Post surgical morbidity will be assessed.

  2019-2020

Interventions

Single-operator cholangioscopy guided electrohydraulic lithotripsy PROCEDURE

Single-operator cholangioscopy guided electrohydraulic lithotripsy has the advantage of providing direct visualization of the bile ducts, enabling a single physician to diagnose and perform the therapeutic intervention in a single procedure.

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

A 34-year-old female, A 54-year-old male, A 40-year-old female. with diagnosed Mirizzi Syndrome by an image study, with a concomitant common bile duct dilatation.

You may qualify if:

• Patients older than 18 years old
• Patients with a preoperative diagnosis of Mirizzi Syndrome
• Patients with a common bile duct dilatation

You may not qualify if:

• Patients younger than 18 years old
• Patients with an inconclusive biliary diagnosis
• Patients without a diagnosis of Mirrizi Syndrome
• Patients without common bile duct dilatation

Sponsors & Collaborators

• Tecnologico de Monterrey: lead

Study Sites (1)

Escuela Nacional de Medicina, Tecnologico de Monterrey

Monterrey, Nuevo León, 76140, Mexico

Location

MeSH Terms

Conditions

Mirizzi Syndrome; Cholelithiasis; Cholecystitis, Acute

Condition Hierarchy (Ancestors)

Cholestasis; Bile Duct Diseases; Biliary Tract Diseases; Digestive System Diseases; Cholecystitis; Gallbladder Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 9, 2020
• First Posted: December 17, 2020
• Study Start: November 1, 2020
• Primary Completion: December 1, 2020
• Study Completion: December 1, 2020
• Last Updated: December 17, 2020

Record last verified: 2020-12

Locations

ME (1)