Serum Lactate in Acute Mesenteric Ischemia

NCT04671979 | Completed

• 1 other identifier: DVO005-1-431-CEI969
• Study Type: observational
• Target: 74
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Acute mesenteric ischemia is a vascular emergency with high mortality because of ambiguous symptomatology and a lack of early diagnostic markers. Lactate dehydrogenase has been described as a mortality biomarker and bowel necrosis length too. Nevertheless, the association between them has been mildly studied. Our objective was to evaluate the association between serum lactate admission levels, bowel necrosis extension, and mortality. Additionally, we performed a mortality characterization. Materials and Methods: A retrospective cross-sectional study was designed. We reviewed patients' clinical records with acute mesenteric ischemia that attended a hospital between 2012 and 2018. We compared serum lactate admission levels with bowel necrosis length and mortality. A receiver operating characteristic curve was performed on the last association. As post hoc analysis, a classification and regression tree on mortality was fitted.

Conditions

Mesenteric Ischemia

Keywords

Biomarker; L-Lactate; Mortality

Outcome Measures

Primary Outcomes (3)

• Serum Lactate in mmol/l

  30 days

• Bowel necrosis length in cm

  30 days

• Percentage of patients that died between 30 postsurgical days, %

  30 days

Secondary Outcomes (1)

• Cut value of lactate levels as a predictor of mortality, in mmol/l

  30 days

Interventions

Lactate Dehydrogenase DIAGNOSTIC_TEST

All the patients that arrived at the hospital with symptoms of mesenteric ischemia, had a registered lactate dehydrogenase. We compared the value with the patient's outcomes.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Seventy-four cases were identified that met the study's criteria. The patients' average age was 73.5 (SD, 10.7) years, and 44 (60%) were men. The mean body mass index was 25 (SD, 2.9) kg/m2. Fifteen (20%) of the patients presented non-occlusive acute mesenteric ischemia.

You may qualify if:

• Older than 18 years of age
• Required urgent laparotomy with a postoperative diagnosis of acute mesenteric ischemia
• Attended the private academic hospital, between 2012 and 2018
• Had a registered serum lactate dehydrogenase at admission

You may not qualify if:

• Secondary causes of AMI
• Chronic intestinal ischemic
• Patient records with no description of the serum lactate dehydrogenase or extension of intestinal necrosis

Sponsors & Collaborators

• Universidad del Rosario: lead

Study Sites (1)

Andres Isaza Restrepo

Bogotá, Cundinamarca, 111221, Colombia

Location

MeSH Terms

Conditions

Mesenteric Ischemia

Condition Hierarchy (Ancestors)

Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Peritoneal Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, MSc

Study Record Dates

• First Submitted: December 3, 2020
• First Posted: December 17, 2020
• Study Start: May 2, 2017
• Primary Completion: June 30, 2020
• Study Completion: June 30, 2020
• Last Updated: December 17, 2020

Record last verified: 2020-12

Data Sharing

• IPD Sharing: Will not share

Locations

CO (1)