NCT04671979|Completed
Serum Lactate in Acute Mesenteric Ischemia
Lactate Dehydrogenase, Bowel Necrosis and Mortality in Acute Mesenteric Ischemia: Retrospective Cross-Sectional
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Lactate Dehydrogenase, Bowel Necrosis and Mortality in Acute Mesenteric Ischemia: Retrospective Cross-Sectional
Sponsor study identifier
observational
74
1 country
1
Study Start
May 2, 2017
Actual (reported)Primary Completion
June 30, 2020
Actual (reported)Study Completion
June 30, 2020
Actual (reported)Background: Acute mesenteric ischemia is a vascular emergency with high mortality because of ambiguous symptomatology and a lack of early diagnostic markers. Lactate dehydrogenase has been described as a mortality biomarker and bowel necrosis length too. Nevertheless, the association between them has been mildly studied. Our objective was to evaluate the association between serum lactate admission levels, bowel necrosis extension, and mortality. Additionally, we performed a mortality characterization. Materials and Methods: A retrospective cross-sectional study was designed. We reviewed patients' clinical records with acute mesenteric ischemia that attended a hospital between 2012 and 2018. We compared serum lactate admission levels with bowel necrosis length and mortality. A receiver operating characteristic curve was performed on the last association. As post hoc analysis, a classification and regression tree on mortality was fitted.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 30, 2020
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 2, 2017
Actual (reported)June 30, 2020
Actual (reported)June 30, 2020
Actual (reported)December 3, 2020
Actual (reported)December 17, 2020
Actual (reported)Serum Lactate in mmol/l
30 days
Bowel necrosis length in cm
30 days
Percentage of patients that died between 30 postsurgical days, %
30 days
Cut value of lactate levels as a predictor of mortality, in mmol/l
30 days
All the patients that arrived at the hospital with symptoms of mesenteric ischemia, had a registered lactate dehydrogenase. We compared the value with the patient's outcomes.
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Seventy-four cases were identified that met the study's criteria. The patients' average age was 73.5 (SD, 10.7) years, and 44 (60%) were men. The mean body mass index was 25 (SD, 2.9) kg/m2. Fifteen (20%) of the patients presented non-occlusive acute mesenteric ischemia.
Andres Isaza Restrepo
Bogotá, Cundinamarca, 111221, Colombia
74 participants (actual enrollment reported by the registry).
First Submitted
December 3, 2020
First Posted
December 17, 2020
Study Start
May 2, 2017
Actual (reported)Registeranalysis for the Examination of NOMI
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Primary Completion
June 30, 2020
Actual (reported)Study Completion
June 30, 2020
Actual (reported)Last Updated
December 17, 2020
Record last verified: 2020-12
We don't plan to share de IPD.
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Source: ClinicalTrials.gov.
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