NCT03484442

Brief Summary

Acute mesenteric ischemia is a life-threatening condition with high mortality. Acute mesenteric ischemia is responsible for fewer than one in 1000 hospital admissions, but its mortality rate ranges between 30% and 90% . Acute mesenteric ischemia is most commonly secondary to embolism followed by arterial thrombosis, non-occlusive ischemia, and less commonly venous thrombosis . Delay in diagnosis contributes to the continued high mortality rate. Early diagnosis and prompt effective treatment are essential to Correspondence to improve clinical outcomes

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
30

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Apr 2018

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 24, 2018

Completed
6 days until next milestone

First Posted

Study publicly available on registry

March 30, 2018

Completed
2 days until next milestone

Study Start

First participant enrolled

April 1, 2018

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2019

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2019

Completed
Last Updated

March 30, 2018

Status Verified

March 1, 2018

Enrollment Period

1 year

First QC Date

March 24, 2018

Last Update Submit

March 24, 2018

Conditions

Mesenteric Ischemia

Outcome Measures

Primary Outcomes (1)

  • rate of diagnosis of Acute mesenteric ischemia

    number of patients accurately diagnosed acute mesenteric ischemia by multislice computed tomography angiography

    48 hours of presentation

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Clinically suspected acute mesentric ischemia based on physician evaluation Patients should be evaluated during 48 h of acute presentation

You may qualify if:

  • Clinically suspected acute mesenteric ischemia based on physician evaluation Patients should be evaluated during 48 h of acute presentation

You may not qualify if:

  • Renal Impairment
  • Known allergy to iodine contrast media.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (10)

  • Ottinger LW. Mesenteric ischemia. N Engl J Med. 1982 Aug 26;307(9):535-7. doi: 10.1056/NEJM198208263070905. No abstract available.

    PMID: 7048095BACKGROUND

  • Ozden N, Gurses B. Mesenteric ischemia in the elderly. Clin Geriatr Med. 2007 Nov;23(4):871-87, vii-viii. doi: 10.1016/j.cger.2007.07.001.

    PMID: 17923343BACKGROUND

  • Herbert GS, Steele SR. Acute and chronic mesenteric ischemia. Surg Clin North Am. 2007 Oct;87(5):1115-34, ix. doi: 10.1016/j.suc.2007.07.016.

    PMID: 17936478BACKGROUND

  • Paterno F, Longo WE. The etiology and pathogenesis of vascular disorders of the intestine. Radiol Clin North Am. 2008 Sep;46(5):877-85, v. doi: 10.1016/j.rcl.2008.06.005.

    PMID: 19103137BACKGROUND

  • Reginelli A, Iacobellis F, Berritto D, Gagliardi G, Di Grezia G, Rossi M, Fonio P, Grassi R. Mesenteric ischemia: the importance of differential diagnosis for the surgeon. BMC Surg. 2013;13 Suppl 2(Suppl 2):S51. doi: 10.1186/1471-2482-13-S2-S51. Epub 2013 Oct 8.

    PMID: 24267670BACKGROUND

  • Cudnik MT, Darbha S, Jones J, Macedo J, Stockton SW, Hiestand BC. The diagnosis of acute mesenteric ischemia: A systematic review and meta-analysis. Acad Emerg Med. 2013 Nov;20(11):1087-100. doi: 10.1111/acem.12254.

    PMID: 24238311BACKGROUND

  • Martinez JP, Hogan GJ. Mesenteric ischemia. Emerg Med Clin North Am. 2004 Nov;22(4):909-28. doi: 10.1016/j.emc.2004.05.002.

    PMID: 15474776BACKGROUND

  • Sise MJ. Acute mesenteric ischemia. Surg Clin North Am. 2014 Feb;94(1):165-81. doi: 10.1016/j.suc.2013.10.012.

    PMID: 24267504BACKGROUND

  • Ofer A, Abadi S, Nitecki S, Karram T, Kogan I, Leiderman M, Shmulevsky P, Israelit S, Engel A. Multidetector CT angiography in the evaluation of acute mesenteric ischemia. Eur Radiol. 2009 Jan;19(1):24-30. doi: 10.1007/s00330-008-1124-5. Epub 2008 Aug 9.

    PMID: 18690454BACKGROUND

  • Menke J. Diagnostic accuracy of multidetector CT in acute mesenteric ischemia: systematic review and meta-analysis. Radiology. 2010 Jul;256(1):93-101. doi: 10.1148/radiol.10091938.

    PMID: 20574087BACKGROUND

MeSH Terms

Conditions

Mesenteric Ischemia

Condition Hierarchy (Ancestors)

Intestinal DiseasesGastrointestinal DiseasesDigestive System DiseasesPeritoneal DiseasesVascular DiseasesCardiovascular Diseases

Central Study Contacts

Afaf Abdel-Qader Hasan Elmamlok, professor

CONTACT

02208843124afaf.kader@aun.edu.eg

Abo-Elhassan Hasseib Mohammed, lecturer

CONTACT

02201009562059abolhasan_96@aun.edu.eg

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
principle investigator

Study Record Dates

First Submitted

March 24, 2018

First Posted

March 30, 2018

Study Start

April 1, 2018

Primary Completion

April 1, 2019

Study Completion

June 1, 2019

Last Updated

March 30, 2018

Record last verified: 2018-03