Impact of Respiratory Rehabilitation on Quality of Life in Patients With Hyperventilation Syndrome

NCT04668638 | Completed

• 1 other identifier: CHRO-2020-19
• Study Type: interventional
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

The hyperventilation syndrome is a quite frequent pathology, affecting up to 10% of the general population and 40% of the asthmatic population. Its physiopathology is still badly known and even if it is a benign affection, its associated comorbidities and symptomatology greatly decrease the patients' quality of life. Yet, no medicinal treatments have been proved useful, but prescribers noticed improvements after physiotherapy. Given that the physiotherapy impact on hyperventilation syndrome is not well described in the literature, this study aims to scientifically ascertain physiotherapy benefits on quality of life and symptomatology in hyperventilation syndrome-suffering patients.

Conditions

Hyperventilation Syndrome

Keywords

Hyperventilation syndrome; Respiratory rehabilitation; Quality of Life

Outcome Measures

Primary Outcomes (3)

• Incidence of respiratory rehabilitation on Quality of life

  Quality of life will be evaluated with the SF-36 score

  Day 0

• Incidence of respiratory rehabilitation on Quality of life

  Quality of life will be evaluated with the SF-36 score

  Month 2

• Incidence of respiratory rehabilitation on Quality of life

  Quality of life will be evaluated with the SF-36 score

  Month 4

Secondary Outcomes (3)

• Change in symptomatology

  Day 0

• Change in symptomatology

  Month 2

• Change in symptomatology

  Month 4

Study Arms (2)

Control group

OTHER

Group 1 (Control Group) will not immediately receive respiratory rehabilitation but between the 2nd and 4th months postdiagnosis.

Other: Respiratory rehabilitation

Intervention group

OTHER

Group 2 (Intervention Group) will immediately receive rehabilitation between the diagnosis and the 2nd month postdiagnosis.

Other: Respiratory rehabilitation

Interventions

Respiratory rehabilitation OTHER

Respiratory rehabilitation includes education, hypoventilation exercises, diaphragmatic breathing exercises, relaxation, retraining, others.

Control group; Intervention group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Positive hyperventilation syndrome diagnosis
• Having a social security insurance
• Being at least 18 years old
• Having given their written consent

You may not qualify if:

• Being put under guardianship or curatorship
• Having seen a physiotherapist for a respiratory rehabilitation in the last three months
• Suffering from a chronic and degenerative pathology (chronic obstructive pulmonary disease, Parkinson's disease, idiopathic fibrosis, …)
• Not being able to receive the respiratory rehabilitation from our care providers
• Already having received a rehabilitation for hyperventilation syndrome
• Not speaking French or not being unable to complete the questionnaires

Sponsors & Collaborators

• Centre Hospitalier Régional d'Orléans: lead

Study Sites (1)

CHR d'Orléans

Orléans, France

Location

Related Publications (12)

• Gardner WN. The pathophysiology of hyperventilation disorders. Chest. 1996 Feb;109(2):516-34. doi: 10.1378/chest.109.2.516. No abstract available.

  PMID: 8620731 BACKGROUND

• Lewis RA, Howell JB. Definition of the hyperventilation syndrome. Bull Eur Physiopathol Respir. 1986 Mar-Apr;22(2):201-5.

  PMID: 3708188 BACKGROUND

• Thomas M, McKinley RK, Freeman E, Foy C. Prevalence of dysfunctional breathing in patients treated for asthma in primary care: cross sectional survey. BMJ. 2001 May 5;322(7294):1098-100. doi: 10.1136/bmj.322.7294.1098.

  PMID: 11337441 BACKGROUND

• Lewis T, Cotton, Barcroft J, Dufton D, Milroy TR, Parsons TR. BREATHLESSNESS IN SOLDIERS SUFFERING FROM IRRITABLE HEART. Br Med J. 1916 Oct 14;2(2911):517-9. doi: 10.1136/bmj.2.2911.517. No abstract available.

  PMID: 20768329 BACKGROUND

• van Dixhoorn J, Duivenvoorden HJ. Efficacy of Nijmegen Questionnaire in recognition of the hyperventilation syndrome. J Psychosom Res. 1985;29(2):199-206. doi: 10.1016/0022-3999(85)90042-x.

  PMID: 4009520 BACKGROUND

• Vansteenkiste J, Rochette F, Demedts M. Diagnostic tests of hyperventilation syndrome. Eur Respir J. 1991 Apr;4(4):393-9.

  PMID: 1855568 BACKGROUND

• Nixon PG. Effort syndrome: hyperventilation and reduction of anaerobic threshold. Biofeedback Self Regul. 1994 Jun;19(2):155-69. doi: 10.1007/BF01776488.

  PMID: 7918753 BACKGROUND

• Chenivesse C, Similowski T, Bautin N, Fournier C, Robin S, Wallaert B, Perez T. Severely impaired health-related quality of life in chronic hyperventilation patients: exploratory data. Respir Med. 2014 Mar;108(3):517-23. doi: 10.1016/j.rmed.2013.10.024. Epub 2013 Nov 7.

  PMID: 24269004 BACKGROUND

• Kraft AR, Hoogduin CA. The hyperventilation syndrome. A pilot study on the effectiveness of treatment. Br J Psychiatry. 1984 Nov;145:538-42. doi: 10.1192/bjp.145.5.538.

  PMID: 6388711 BACKGROUND

• Van De Ven LL, Mouthaan BJ, Hoes MJ. Treatment of the hyperventilation syndrome with bisoprolol: a placebo-controlled clinical trial. J Psychosom Res. 1995 Nov;39(8):1007-13. doi: 10.1016/0022-3999(95)00508-0.

  PMID: 8926595 BACKGROUND

• Hoes MJ, Colla P, Folgering H. Clomipramine treatment of hyperventilation syndrome. Pharmakopsychiatr Neuropsychopharmakol. 1980 Jan;13(1):25-8. doi: 10.1055/s-2007-1019606.

  PMID: 7367465 BACKGROUND

• Jones M, Harvey A, Marston L, O'Connell NE. Breathing exercises for dysfunctional breathing/hyperventilation syndrome in adults. Cochrane Database Syst Rev. 2013 May 31;2013(5):CD009041. doi: 10.1002/14651858.CD009041.pub2.

  PMID: 23728685 BACKGROUND

Study Officials

• Louis-François BIRNESSER

  CHR Orléans

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Patients will be divided into two groups: * Group 1 (Control Group) will not immediately receive respiratory rehabilitation but between the 2nd and 4th months postdiagnosis. * Group 2 (Intervention Group) will immediately receive rehabilitation between the diagnosis and the 2nd month postdiagnosis.

Study Record Dates

• First Submitted: December 9, 2020
• First Posted: December 16, 2020
• Study Start: March 10, 2021
• Primary Completion: July 1, 2025
• Study Completion: July 1, 2025
• Last Updated: July 22, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)