A Multicenter, Open-label, Single-arm, Expanded Access Protocol of Sotorasib for the Treatment of Subjects With Previously Treated Locally Advanced Unresectable/Metastatic NSCLC With KRAS p.G12C Mutation
Sponsor study identifier
expanded_access
N/A
6 countries
55
Study Start
Not reported
Date not reportedPrimary Completion
Not reported
Date not reportedStudy Completion
Not reported
Date not reportedThe primary objective of this study is to provide expanded access to and characterize the safety profile of Sotorasib in participants with previously treated locally advanced/unresectable/metastatic non small-cell lung cancer (NSCLC) with KRAS p.G12C mutation in a real-world setting.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
Not reported
Date not reportedClick on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 8, 2020
Actual (reported)December 14, 2020
Actual (reported)Clearview Cancer Institute
Huntsville, Alabama, 35805, United States
Alaska Oncology and Hematology LLC
Anchorage, Alaska, 99508, United States
Ironwood Cancer and Research Center
Chandler, Arizona, 85224, United States
Arizona Oncology Associates Professional Corporation
Tucson, Arizona, 85711, United States
San Luis Valley Health Regional Medical Center
Alamosa, Colorado, 81101, United States
Kaiser Permanente
Lone Tree, Colorado, 80124, United States
Sacred Heart Medical Oncology Group
Novello S, Rabinovich NM, Shih JY, Pelizzari G, Stevenson J, Majem M, Ferreira CG, Petty WJ, Arriola E, Castagneris N, De Castro J, Morbeck I, Bauman J, Toschi L, Zer A, Metro G, Kalmadi S, Martinez AA, Al Husaini H, Meloni AR, Nduka C, Ardito-Abraham C, Xia C, Awad MM. Sotorasib in Advanced KRAS G12C-Mutated NSCLC: Results From the Global Expanded Access Program, Including Patients With Poor Performance Status and a History of CNS Metastases. JTO Clin Res Rep. 2026 Feb 13;7(5):100974. doi: 10.1016/j.jtocrr.2026.100974. eCollection 2026 May.
MD
Amgen
First Submitted
December 8, 2020
First Posted
December 14, 2020
Last Updated
August 20, 2026
Record last verified: 2025-08
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Source: ClinicalTrials.gov.
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Source retrieved:
Contact the study team to confirm eligibility.
Pensacola, Florida, 32504, United States
Cancer Care Specialists of Central Illinois
Decatur, Illinois, 62526, United States
McFarland Clinic PC
Ames, Iowa, 50010, United States
Des Moines Oncology Research Association
Des Moines, Iowa, 50309, United States
Saint Joseph East
Lexington, Kentucky, 40509, United States
Louisiana Hematology Oncology Associates
Baton Rouge, Louisiana, 70809, United States
Northern Light Cancer Center
Brewer, Maine, 04412, United States
University of Pittsburgh Medical Center Western Maryland
Cumberland, Maryland, 21502, United States
Maryland Oncology Hematology, PA
Rockville, Maryland, 20850, United States
Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
Mid Michigan Medical Center
Midland, Michigan, 48640, United States
Saint Lukes Cancer Institute
Kansas City, Missouri, 64111, United States
Oncology Hematology Associates
Springfield, Missouri, 65807, United States
Nebraska Cancer Specialists
Omaha, Nebraska, 68130, United States
Englewood Hospital and Medical Center
Englewood, New Jersey, 07631, United States
Overlook Medical Center
Summit, New Jersey, 91010, United States
Wake Forest Baptist Comprehensive Cancer Research Center
Winston-Salem, North Carolina, 27157, United States
Cleveland Clinic Taussig Cancer Institute
Cleveland, Ohio, 44195, United States
LeHigh Valley Hospital
Allentown, Pennsylvania, 18103, United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
Scranton Hematology Oncology
Scranton, Pennsylvania, 18510, United States
Erlanger East Hospital
Chattanooga, Tennessee, 37421, United States
Baptist Cancer Center
Memphis, Tennessee, 38120, United States
Saint Marys Medical Center
Huntington, West Virginia, 25705, United States
Instituto Médico Especializado Alexander Fleming
Capital Federal, Buenos Aires, C1426ANZ, Argentina
Hospital Aleman
Ciudad Autonoma de Buenos Aires, Buenos Aires, C1118AAT, Argentina
Cemic
Ciudad Autonoma de Buenos Aires, Buenos Aires, C1431FWO, Argentina
Clínica Universitaria Privada Reina Fabiola
Córdoba, Córdoba Province, X5004FHP, Argentina
Hospital Sirio Libanes
Brasília, Federal District, 70200-730, Brazil
Personal Oncologia de Precisao e Personalizada
Belo Horizonte, Minas Gerais, 30130-090, Brazil
Instituto de Oncologia do Parana
Curitiba, Paraná, 80040-170, Brazil
Liga Norte-Riograndense Contra O Cancer
Natal, Rio Grande do Norte, 59075-740, Brazil
YNOVA Pesquisa Clinica
Florianópolis, Santa Catarina, 88034-000, Brazil
Fundacao Pio 12 Hospital de Cancer de Barretos
Barretos, São Paulo, 14784-400, Brazil
Oncoclinicas Rio de Janeiro S A
Rio de Janeiro/RJ, 22250-905, Brazil
Meir Medical Center
Kfar Saba, 4428164, Israel
Rabin Medical Center
Petah Tikva, 4941492, Israel
Shaare Zedek Medical Center
Petah Tikva, 4941492, Israel
King Fahad Specialist Hospital
Dammam, 32253, Saudi Arabia
King Abdulaziz Medical City - National Guard Hospital
Riyadh, 11426, Saudi Arabia
King Saud University Medical City-King Khalid University Hospital
Riyadh, 12372, Saudi Arabia
King Faisal Specialist Hospital
Riyadh, 12713, Saudi Arabia
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Kaohsiung, 83301, Taiwan
Chung Shan Medical University Hospital
Taichung, Taichung, 40201, Taiwan
Veterans General Hospital - Taichung
Taichung, Taichung, 40705, Taiwan
National Cheng Kung University Hospital
Tainan, Tainan, 70403, Taiwan
National Taiwan University Hospital
Taipei, Taipei, 10002, Taiwan
Taipei Veterans General Hospital
Taipei, Taipei, 11217, Taiwan
Linkou Chang Gung Memorial Hospital
Taoyuan, Taoyuan, 33305, Taiwan