A Prognostic Model to PREDICT Relapse of Depression in Primary Care
PREDICTR
Development and Validation of a Prognostic Model to PREDICT Relapse of Depression in Adult Patients in Primary Care
1 other identifier
observational
1,244
1 country
1
Brief Summary
The investigators aim to develop a prognostic model to predict the risk of relapse within 6-8 months of patients entering remission. The long-term objective is to facilitate more efficient targeting of evidence-based relapse prevention strategies to these patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2021
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 7, 2020
CompletedFirst Posted
Study publicly available on registry
December 14, 2020
CompletedStudy Start
First participant enrolled
February 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 24, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
June 24, 2024
CompletedJune 25, 2024
June 1, 2024
3.4 years
December 7, 2020
June 24, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Whether a participant relapses or not within 6-8 months (binary outcome)
Relapse is the re-emergence of depressive symptoms according to Patient Health Questionnaire (PHQ-9)
6-8 months
Eligibility Criteria
The study population will represent an undifferentiated primary care case-mix of patients with depression, meeting clinical criteria for remission at the point of prediction.
You may qualify if:
- Remitted depressive disorder
You may not qualify if:
- Co-existing severe mental illness
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Yorklead
- National Institute for Health Research, United Kingdomcollaborator
- Keele Universitycollaborator
Study Sites (1)
University of York
York, United Kingdom
Related Publications (2)
Moriarty AS, Paton LW, Snell KIE, Archer L, Riley RD, Buckman JEJ, Chew Graham CA, Gilbody S, Ali S, Pilling S, Meader N, Phillips B, Coventry PA, Delgadillo J, Richards DA, Salisbury C, McMillan D. Development and validation of a prognostic model to predict relapse in adults with remitted depression in primary care: secondary analysis of pooled individual participant data from multiple studies. BMJ Ment Health. 2024 Oct 28;27(1):e301226. doi: 10.1136/bmjment-2024-301226.
PMID: 39467616DERIVEDMoriarty AS, Paton LW, Snell KIE, Riley RD, Buckman JEJ, Gilbody S, Chew-Graham CA, Ali S, Pilling S, Meader N, Phillips B, Coventry PA, Delgadillo J, Richards DA, Salisbury C, McMillan D. The development and validation of a prognostic model to PREDICT Relapse of depression in adult patients in primary care: protocol for the PREDICTR study. Diagn Progn Res. 2021 Jul 2;5(1):12. doi: 10.1186/s41512-021-00101-x.
PMID: 34215317DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Andrew Moriarty, MRes
University of York
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- NIHR Doctoral Research Fellow
Study Record Dates
First Submitted
December 7, 2020
First Posted
December 14, 2020
Study Start
February 1, 2021
Primary Completion
June 24, 2024
Study Completion
June 24, 2024
Last Updated
June 25, 2024
Record last verified: 2024-06