Aerobic Exercise and Sensorimotor Adaptation in Chronic Stroke

NCT04657029 | Completed

• 1 other identifier: ChrisMackaySensMotStroke2020
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

A single-blinded crossover study. Participants attended two separate sessions at the university campus, completing an aerobic exercise intervention in one session and a resting control condition in the other session. Sensorimotor adaptation was assessed before and after each session. Participants were twenty people with chronic stroke. Intervention completed was treadmill exercise at mod-high intensity for 30 minutes.

Conditions

Stroke

Keywords

sensorimotor adaptation; aerobic exercise

Outcome Measures

Primary Outcomes (1)

• Sensorimotor adaptation change

  Participants were seated in front of a desk and asked to move a digitising pen on a digitizing tablet from an origin to a target point. The pen's position on the tablet (XY coordinates) was sampled at 100 Hz and displayed in real time as a circular cursor with a 5-pixel radius (1.25 mm) on a horizontally placed computer monitor. Direct vision of the hand was prevented by placing the tablet and the hand directly beneath an opaque stand, with the horizontal monitor placed atop the stand.

  Pre and Post intervention and Pre and Post Control. There was one week between the two conditions

Study Arms (2)

Treadmill condition

EXPERIMENTAL

The intervention condition consisted of a single session of moderate-high intensity aerobic exercise (65% of heart rate reserve) for 30 minutes walking on a standard treadmill. The single treadmill session included a progressive increase in intensity to reach the target heart rate (approx. 5 mins) as well as a cooling down period (approx. 5 mins). The warm-up and cool-down were included as part of the total 30 minutes of walking exercise. Target heart rates were calculated using the Karvonen method \[25\] with levels adjusted for those taking heart rate lowering medications (i.e. beta blockers), following methods previously published in post stroke populations \[26, 27\]. Participants were asked to self-rate their intensity of exercise every 10 minutes verbally using BORG's 6-20 scale rating of perceived exertion \[28\]. Participants were instructed to walk at a pace that resulted in a rating between 11 (fairly light) and 14 (somewhat hard) on the scale.

Behavioral: Treadmill

Control condition

OTHER

The control condition involved an equivalent time period (30 minutes) of seated resting where participants were provided with an education session about the impact and effects of stroke by the same research assistant.

Behavioral: Treadmill

Interventions

Treadmill BEHAVIORAL

30 minutes of moderate-high intensity treadmill training.

Control condition; Treadmill condition

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Clinical diagnosis of stroke
• Time of stroke greater than three months ago
• Be able to walk with or without and aid for at least 10 metres
• Understand three stage commands

You may not qualify if:

• Unable to walk independently prior to current stroke
• Have co-morbidities that limit their walking (e.g. arthritis, orthopaedic surgery)
• Unstable cardiac status
• Unable to understand three stage commands
• Unable to provide informed consent

Sponsors & Collaborators

• The University of Queensland: lead

Study Sites (1)

The University of Queensland

Brisbane, Queensland, 4072, Australia

Location

Related Publications (1)

• Neva JL, Ma JA, Orsholits D, Boisgontier MP, Boyd LA. The effects of acute exercise on visuomotor adaptation, learning, and inter-limb transfer. Exp Brain Res. 2019 Apr;237(4):1109-1127. doi: 10.1007/s00221-019-05491-5. Epub 2019 Feb 18.

  PMID: 30778618 BACKGROUND

MeSH Terms

Conditions

Stroke

Interventions

Exercise Test

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Ergometry; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Blinded Assessors
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: In a cross-over design, each participant was pseudo-randomised to complete an intervention condition (Treadmill) or control condition (Rest) first, returning at least one week later (washout period) to complete the alternate condition. A minimum washout period of one week was used to allow for any physiological changes due to exercise to return to resting levels, but to minimise any stroke recovery-associated changes to function. Participants were asked to refrain from exercising in the 24 hours prior to their visit. At each visit, participants completed the sensorimotor adaptation task on two occasions, pre and post intervention, resulting in four assessment timepoints (PreControl, PostControl and PreTreadmill, PostTreadmill). The post intervention assessment aimed to commence within 15 minutes of completing the treadmill or rest condition.

Study Record Dates

• First Submitted: November 22, 2020
• First Posted: December 8, 2020
• Study Start: June 1, 2017
• Primary Completion: July 1, 2019
• Study Completion: March 1, 2020
• Last Updated: December 8, 2020

Record last verified: 2020-11

Data Sharing

• IPD Sharing: Will not share

Locations

AU (1)