Relationship Between Digital Vascular Function Measured by EndoPAT® in elderlY Patients and Arterial Stiffness

NCT04651894 | Completed

• 1 other identifier: 2020PI228
• Study Type: observational
• Target: 148
• Locations: 1 country
• Sites: 1

Brief Summary

Due to the aging of populations worldwide, we observe an increase of age-related diseases and loss of autonomy with consequent personal, social, medical and economic implications. The aging population is a target for geriatric medicine, necessitating the development of specific diagnostic and therapeutic approaches in order to estimate cardio vascular risk in these individuals. It is thought that arterial stiffening and endothelial dysfunction are among the earliest vascular properties altered with the onset of cardiovascular disease. Moreover aging is characterized by progressive fragmentation and break down of the elastic components of the aortic media, which are partially replaced by highly cross-linked collagen leading to stiffening, dilation, and elongation of the aorta . A major underlying mechanism of these modifications is endothelial dysfunction due to high oxidative stress and low-grade inflammation. Reactive hyperemia index (RHI), a key outcome of peripheral arterial tonometry (PAT) has recently become a reliable tool to measure microvascular endothelial function. Some studies have recently demonstrated the interest to measure in elderly patients arterial stiffness parameters in order to prevent loss of autonomy. This cross sectional study aimed at demonstrating the link between arterial stiffness evaluated by pulse wave velocity and endothelial dysfunction evaluated by RHI to implement the tools of cardio vascular risk evaluation in a population of elderly patients referred in a geriatric day hospital.

Conditions

Arterial Disease; Frail Elderly Syndrome; Stiffness, Vascular; Endothelial Degeneration

Keywords

endothelial dysfunction; elderly; arterial stiffness; pulse wave velocity; geroscience; vascular aging

Outcome Measures

Primary Outcomes (1)

• endothelial dysfunction

  RHI measurement

  20 minutes

Secondary Outcomes (2)

• pulse wave velocity

  10 minutes

• PAT signal QUALITY

  10 minutes

Interventions

reactive hyperaemia index measurement DEVICE

reactive hyperaemia index with EndoPAT® Pulse wave velocity measurement with Sphygmocor®

Also known as: pulse wave velocity measurement

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

105 among these 148 patients were finally selected as they present ENDOPAT good signal

You may qualify if:

• age over 60 years
• referred to a day hospital check up
• arterial stiffness evaluation
• peripheral Arterial Tonometry Evaluation

You may not qualify if:

• atrial fibrillation during examination
• poor quality of the signals

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Study Sites (1)

CHRU Nancy

Vandœuvre-lès-Nancy, Lorraine, 54511, France

Location

Study Officials

• Laure Joly, Professor

  University of Lorraine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 26, 2020
• First Posted: December 3, 2020
• Study Start: May 1, 2018
• Primary Completion: December 31, 2019
• Study Completion: November 3, 2020
• Last Updated: December 4, 2020

Record last verified: 2020-12

Locations

FR (1)