The HUNT for Heart Failure" Risk Score

NCT04648852 | Completed DMC

• 1 other identifier: LH-20H4HF
• Study Type: observational
• Target: 36,511
• Locations: 1 country
• Sites: 1

Brief Summary

In this population study aim is to evaluate risk factors for heart failure and combine these into a new heart failure risk score. Secondly, the heart failure risk score will be internally and externally validated, and compared with established heart failure risk scores. Additionally, the prevalence of heart failure as well as the distribution of the heart failure risk score in the general population will be evaluated.

Conditions

Heart Failure

Keywords

risk factor; population; diagnosis; prognosis

Outcome Measures

Primary Outcomes (1)

• Time to incident heart failure event

  Time to first heart failure hospitalization or heart failure related visit at the out-patient clinic (events defined according to the ESC 2016 heart failure guidelines)

  10 years

Secondary Outcomes (3)

• Time to death from any cause

  10 years

• Time to first heart failure event or death from any cause

  10 years

• Validity of heart failure risk score

  10 years

Other Outcomes (2)

• Prevalence of heart failure

  0 days

• Distribution of heart failure risk score categories

  0 days

Study Arms (2)

Participants in the third wave of the HUNT study

General population participating in the third wave of the HUNT study

Other: Heart failure risk estimation

Participants in the second wave of the HUNT study

General population participating in the second wave of the HUNT study

Other: Heart failure risk estimation

Interventions

Heart failure risk estimation OTHER

Evaluation by heart failure risk score

Participants in the second wave of the HUNT study; Participants in the third wave of the HUNT study

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

General population

You may qualify if:

• Participation in the third or second wave of the HUNT study

You may not qualify if:

• Not willing to participate
• Missing vital data

Sponsors & Collaborators

• Helse Nord-Trøndelag HF: lead
• Boehringer Ingelheim: collaborator
• Norwegian University of Science and Technology: collaborator
• Vestre Viken Hospital Trust: collaborator

Study Sites (1)

Levanger hospital

Levanger, Norge, 7600, Norway

Location

Related Publications (1)

• Ofstad AP, Brunborg C, Johansen OE, Morkedal B, Fagerland MW, Laugsand LE, Gullestad LL, Dalen H. Development of a tool to predict the risk of incident heart failure in a general population: the HUNT for HF risk score. ESC Heart Fail. 2023 Oct;10(5):2807-2815. doi: 10.1002/ehf2.14390. Epub 2023 May 29.

  PMID: 37248650 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Biobank available, but not included in this project. Laboratory test made available are haematology overview, renal function serology, C-reactive protein

MeSH Terms

Conditions

Heart Failure; Disease

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Håvard Dalen, MSc, PhD

  Helse Nord-Trøndelag HF

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: PROSPECTIVE
• Target Duration: 20 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 24, 2020
• First Posted: December 2, 2020
• Study Start: October 1, 2017
• Primary Completion: June 30, 2023
• Study Completion: June 30, 2023
• Last Updated: June 15, 2025

Record last verified: 2025-06

Locations

NO (1)