The Relationship Between Covid-19 Infection in Pediatric Patients and Secondary Lymphoid Organs

NCT04646525 | Unknown

• 1 other identifier: 2020/480
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

We aimed to find out whether the tonsils and nasal tissues of pediatric patients are the main factors that protects the children's immune system against COVID-19 infection.

Conditions

Covid19; Immune Deficiency; Tonsillitis; Tonsil Hypertrophy; Adenoiditis; Adenoid Hypertrophy

Keywords

pediatric; covid19; İmmune system

Outcome Measures

Primary Outcomes (1)

• The primary outcome of our study was the evaluation of pediatric patients diagnosed with COVID-19 and who had COVID-19 infection in terms of adenoid and tonsillar tissue hypertrophy and the presence of chronic or recurrent infection.

  The structure of the tonsil and adenoid tissues will be examined by physical examination, and the presence of tonsil and adenoid hypertrophy, tonsillitis, and adenoiditis conditions will be identified. The severity of covid-19 will be determined according to the cases of patients with tonsil and adenoid tissue disorders, who are hospitalized in intensive care, have infiltration in the lungs, and receive oxygen support.

  2020-2021

Interventions

Physical examination DIAGNOSTIC_TEST

Pediatric patients diagnosed with COVID-19 and who have had infection will be examined, adenoid and tonsillar tissues will be evaluated in terms of hypertrophy, chronic, or recurrent infection.

Also known as: Only the tonsil and adenoid tissues of the patients will be examined by physical examination, no intervention will be done

Eligibility Criteria

• Age: 1 Year - 16 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Pediatric patients between the ages of 1-16 diagnosed with Covid-19 will be examined by the ENT doctor in terms of tonsil and adenoid tissues after they overcome the active infection period and PCR tests turn negative.

You may qualify if:

• Patients with COVID-19 infection.
• Patients aged between 1-16 years
• Patients whose PCR test becomes negative

You may not qualify if:

• Patients with lymphoid tissue malignant disease
• Patients with known lung disease
• Patients with known systemic disease

Sponsors & Collaborators

• Selcuk University: lead

Study Sites (1)

Selcuk University

Konya, Selcuklu, 42100, Turkey (Türkiye)

RECRUITING

Related Publications (2)

• Brodin P. Why is COVID-19 so mild in children? Acta Paediatr. 2020 Jun;109(6):1082-1083. doi: 10.1111/apa.15271. Epub 2020 Apr 15. No abstract available.

  PMID: 32212348 BACKGROUND

• Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, Tong S. Epidemiology of COVID-19 Among Children in China. Pediatrics. 2020 Jun;145(6):e20200702. doi: 10.1542/peds.2020-0702. Epub 2020 Mar 16.

  PMID: 32179660 BACKGROUND

MeSH Terms

Conditions

COVID-19; Immunologic Deficiency Syndromes; Tonsillitis

Interventions

Physical Examination

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Immune System Diseases; Pharyngitis; Pharyngeal Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Merih Onal, Assist. Prof.

  Selcuk University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Selcen Celik

CONTACT

+9033222443963; etikselcuk@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: November 5, 2020
• First Posted: November 30, 2020
• Study Start: October 1, 2020
• Primary Completion: February 1, 2021
• Study Completion: February 1, 2021
• Last Updated: November 30, 2020

Record last verified: 2020-11

Locations

TU (1)