Substituting Sitting With Standing and Walking in Free-living Conditions Improves Daily Glucose Profile in South Asians

NCT04645875 | Completed Results DMC

• 1 other identifier: 2020ISPAR006
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the effects of substituting sitting under free-living conditions in South Asian adults with overweight and obesity on continuous glucose profiles.

Conditions

Cardiovascular Risk Factor; Cardiovascular Diseases; Diabetes; Type 2 Diabetes; Sedentary Behavior; Sedentary Lifestyle

Outcome Measures

Primary Outcomes (1)

• Glycaemia

  Net incremental area under the curve (iAUC), calculated by subtracting waking glucose concentration for each day from the total AUC. Waking hours were identified individually for each participant from activPAL data and then normalised to a 16 h day. Each of these variables was calculated as the mean of valid days within each regimen. A minimum of one valid day that coincided with both FGM and activPAL data was required in each experimental regimen for inclusion in the analysis.

  Mean net incremental area under the curve for waking hours (16 h) interstitial glucose concentration per day for 4 valid days during each intervention

Secondary Outcomes (3)

• Sitting Time

  Mean total sitting time per day for 4 valid days during each intervention

• Standing Time

  Mean standing time per day for 4 valid days during each intervention

• Total Stepping Time

  Mean total stepping time per day for 4 valid days during each intervention

Study Arms (2)

SIT regimen, then SITless regimen

EXPERIMENTAL

Firstly, participants performed the SIT regimen (4 days) where they were instructed to restrict walking to ≤1 h/day and standing to ≤1 h/day during their waking day. Participants were allowed to perform their daily activities, including cooking and other household activities, within the 2-h of permitted walking and standing. After a washout period of 3 days, they then performed the SITless regimen (4 days). SIT regimen: See SIT regimen arm description SITless regimen: See SITless regimen arm description

Other: SIT regimen

SITless regimen, then SIT regimen

EXPERIMENTAL

Firstly, participants performed the SITLess regimen (4 days) where they were instructed to substitute a minimum of 5-h/day sitting with ≥3-h of standing and ≥2-h of self-perceived LPA in addition to interrupting their sitting for 2-5-min every 30-min. A list of activities (including walking at a slow pace, walking on the spot, jumping up and down, and standing) was provided as examples of activities that particpants could perform during this regimen. After a washout period of 3 days, they then performed the SIT regimen (4 days). SITless regimen: See SITless regimen arm description SIT regimen: See SIT regimen arm description

Other: SITless regimen

Interventions

SIT regimen OTHER

See SIT regimen arm description

SIT regimen, then SITless regimen

SITless regimen OTHER

See SITless regimen arm description

SITless regimen, then SIT regimen

Eligibility Criteria

• Age: 18 Years - 75 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Self-identified South Asian ethnicity.
• Self-report sitting at least 7 hours per day.
• Overweight or obese (BMI\>23.0 kg/m2)

You may not qualify if:

• Unable to speak and read English.
• Not able to perform light-intensity activities.
• Diagnosed cardiovascular disease or diabetes.

Sponsors & Collaborators

• University of Bedfordshire: lead
• Brunel University: collaborator

Study Sites (1)

University of Bedfordshire

Bedford, MK41 9EA, United Kingdom

Location

Related Publications (1)

• Dey KC, Zakrzewski-Fruer JK, Smith LR, Jones RL, Maylor BD, Yates TE, Bailey DP. Substituting sitting with standing and walking in free-living conditions improves daily glucose concentrations in South Asian adults living with overweight/obesity. Eur J Appl Physiol. 2026 Jan;126(1):579-589. doi: 10.1007/s00421-025-05919-7. Epub 2025 Aug 5.

  PMID: 40764840 DERIVED

MeSH Terms

Conditions

Cardiovascular Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2; Sedentary Behavior

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Behavior

Results Point of Contact

• Title: Dr Kamalesh Dey
• Organization: University of Bedfordshire

k.dey@qmul.ac.uk

07305192256

Study Officials

• Kamalesh DEY, PhD

  University of Bedfordshire

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Reader in Sedentary Behaviour and Health

Study Record Dates

• First Submitted: November 19, 2020
• First Posted: November 27, 2020
• Study Start: November 19, 2020
• Primary Completion: July 31, 2021
• Study Completion: July 31, 2021
• Last Updated: March 24, 2026
• Results First Posted: March 24, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)