Effects of Breaking up Prolonged Sitting on Postprandial Cardiometabolic Disease Risk Markers in South Asian Adults

NCT03898206 | Completed Results

• 1 other identifier: 2019ISPAR003
• Study Type: interventional
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine whether breaking up prolonged sitting with short regular bouts of walking can reduce blood sugar and cholesterol levels after eating, which are risk markers for Type 2 diabetes and heart disease. This study will compare these responses in normal-weight versus overweight/obese South Asian adults.

Conditions

Cardiovascular Risk Factor; Cardiovascular Diseases; Diabetes; Physical Activity; Sedentary Lifestyle

Outcome Measures

Primary Outcomes (1)

• Postprandial Glucose

  Incremental area under the curve for each 5 h condition will be calculated for glucose

  Measured over the 5 hour condition period

Secondary Outcomes (8)

• Postprandial Triglycerides

  Measured over the 5 hour condition period

• Postprandial Insulin

  Measured over the 5 hour condition period

• Metabolic Load Index

  Measured over the 5 hour condition period

• Resting Energy Expenditure

  Measured for the 5 hour condition period

• Resting Fat Oxidation

  Measured for the 5 hour condition period

Study Arms (2)

Prolonged sitting (SIT), then breaking up sitting with walking breaks (INT-SIT)

EXPERIMENTAL

Firstly, participants will remain seated for 5 h and instructed to reduce excessive movement, only rising from the chair to void. After a washout period of at least 3 days, they then performed the INT-SIT condition. Prolonged sitting (SIT): See SIT arm description Breaking up sitting with walking breaks (INT-SIT): See INT-SIT arm description

Other: Prolonged sitting (SIT)

Breaking up sitting with walking breaks (INT-SIT), then prolonged sitting (SIT)

EXPERIMENTAL

Firstly, participants will rise from the seated position every 30 min throughout the experimental period to walk on a motorised treadmill at a light intensity walking (as determined during the preliminary test) for 5 min. Participants will start walk on a treadmill at 30 min (so physical activity would be at 30-35 min), 60 min (physical activity will be at 60-65 min), 90 min (physical activity will be at 90-95 min), 120 min (physical activity will be 120-125 min), 150 min (physical activity will be at 150-155 min ), and 180 min (physical activity will be at 180-185 min) in the breakfast postprandial period and 30 min (physical activity will be 30-35 min), 60 min (physical activity will be at 60-65 min), and 90 min (physical activity will be at 90-95 min) in the lunch postprandial period. After performing a walking activity, they will return to the seated position. After a washout period of at least 3 days, they then performed the SIT condition. SIT : See SIT arm description

Other: Breaking up sitting with walking breaks (INT-SIT)

Interventions

Breaking up sitting with walking breaks (INT-SIT) OTHER

See Breaking up sitting with walking breaks arm description

Breaking up sitting with walking breaks (INT-SIT), then prolonged sitting (SIT)

Prolonged sitting (SIT) OTHER

See Prolonged sitting arm description

Prolonged sitting (SIT), then breaking up sitting with walking breaks (INT-SIT)

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Self-identified South Asian ethnicity.
• Self-report sitting at least 7 hours per day.
• Normal weight, overweight or obese.

You may not qualify if:

• Unable to speak and read English.
• Contraindications to performing light-intensity walking.
• Diagnosed cardiovascular disease or diabetes.

Sponsors & Collaborators

• University of Bedfordshire: lead
• Brunel University: collaborator

Study Sites (1)

University of Bedfordshire

Bedford, Bedfordshire, MK41 9EA, United Kingdom

Location

MeSH Terms

Conditions

Cardiovascular Diseases; Diabetes Mellitus; Motor Activity; Sedentary Behavior

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Behavior

Results Point of Contact

• Title: Dr Kamalesh Dey
• Organization: University of Bedfordshire

k.dey@qmul.ac.uk

07305192256

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Reader in Sedentary Behaviour and Health

Study Record Dates

• First Submitted: March 28, 2019
• First Posted: April 1, 2019
• Study Start: April 26, 2019
• Primary Completion: March 20, 2020
• Study Completion: March 20, 2020
• Last Updated: April 21, 2026
• Results First Posted: April 21, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)