Physical Activity and Cognitive Function in Older Adults: A Novel Role for GPLD1

NCT04645134 | Completed

• 1 other identifier: PBRC 2020-050
• Study Type: observational
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators are conducting a cross-sectional, observational study to investigate whether plasma GPLD1 concentrations are associated with higher cognitive function and better brain structure and function in two groups of older adults with high or low levels of physical activity.

Conditions

Aging; Cognitive Dysfunction

Outcome Measures

Primary Outcomes (1)

• Plasma concentrations of GPLD1

  Plasma GPLD1 (by a blood draw) is performed.

  1 day

Secondary Outcomes (4)

• Physical activity level

  7 days

• Total grey matter volume

  1 day

• Brain activity and function

  1 day

• Cognitive function

  1 day

Study Arms (2)

Inactive

Older adults who have a sedentary or under-active lifestyle.

Behavioral: Brain Health Assessments

Highly Active

Older adults who have a highly active lifestyle.

Behavioral: Brain Health Assessments

Interventions

Brain Health Assessments BEHAVIORAL

The investigators are enrolling up to 28 healthy, older adults (ages 65-85 y, BMI 20-35 kg/m2) stratified by current physical activity level (equal inactive vs. equal highly active). Each physical activity group (inactive and highly active) will undergo a blood draw, body composition, resting metabolic rate, cognitive testing, and magnetic resonance (MR) imaging.

Highly Active; Inactive

Eligibility Criteria

• Age: 65 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Up to 28 healthy, older adults (ages 65-85 y, BMI 20-35 kg/m2) stratified by current physical activity level will be enrolled. The investigators will enroll an equal number of inactive adults and an equal number of highly active adults.

You may qualify if:

• Ages 65-85 y (inclusive)
• Body mass index (BMI) of 20-35 kg/m2 (inclusive)
• Willing to have blood and data stored for future research use

You may not qualify if:

• History of clinically diagnosed diabetes (Type 1 or 2) or a fasting blood glucose \>126 mg/dL
• Diagnosed Alzheimer's disease, dementia, or related-brain diseases
• Chronic use of atypical antipsychotic or bipolar medications
• Initiation of novel pharmacotherapy agents (such as antidepressant, hypertension, or dyslipidemia) within the last 3 months
• Uncontrolled hypertension (blood pressure \>160 systolic or \>110 diastolic)
• Asthma that limits the ability to participate in moderate to vigorous physical activity or requiring systemic glucocorticoid administration
• Emphysema that limits the ability to participate in moderate to vigorous physical activity or requiring systemic glucocorticoid administration
• Current alcohol use exceeding 14 drinks per week in women, exceeding 21 drinks per week in men, having treatment for alcohol abuse in the last year, or having treatment for alcohol abuse more than 1 year ago (but with inability to refrain from alcohol in the past year)
• Use of illegal drugs or marijuana within 1-month of completing a Screening Visit; treatment for drug addiction in the 1-year or having treatment for drug addiction \>1-year ago, but with an inability to refrain from the drug of addiction in the 1-year
• Unwilling to abstain from illegal drugs and marijuana for the duration of the study
• Contraindication for MRI (e.g., metal objects, claustrophobia, etc.)
• Psychotic mental illness (e.g., schizophrenia, bipolar, on-and- off use of anti-psychotic medication)
• History of cardiovascular disease (or diseases of the heart, lungs, or blood) that limits participation in moderate to vigorous physical activity
• History of liver, blood, kidney, thyroid or other diseases that limits moderate to vigorous physical activity at the time of enrollment
• Cancer that limits moderate to vigorous physical activity

Sponsors & Collaborators

• Pennington Biomedical Research Center: lead

Study Sites (1)

Pennington Biomedical Research Center

Baton Rouge, Louisiana, 70808, United States

Location

Related Publications (1)

• Marlatt KL, Lowe AC, Sanchez-Delgado G, Beyl RA, Viverito MK, Keller JN, Carmichael OT, Ravussin E. Associations between physical activity, brain health, cognitive function, and circulating GPLD1 in healthy older (65-85 years) individuals. Geroscience. 2025 Jun;47(3):3821-3834. doi: 10.1007/s11357-024-01459-8. Epub 2025 Jan 6.

  PMID: 39762691 DERIVED

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Kara L Marlatt, PhD, MPH

  Pennington Biomedical Research Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Executive Director for Clinical Science

Study Record Dates

• First Submitted: November 22, 2020
• First Posted: November 27, 2020
• Study Start: April 1, 2021
• Primary Completion: March 17, 2022
• Study Completion: March 17, 2022
• Last Updated: November 16, 2022

Record last verified: 2022-11

Locations

US (1)