Effect of Motor Entrainment to Auditory Cues and Music During Walking on Quality of Movement and Percieved Fatigue in Persons With Multiple Sclerosis With Cerebellar Lesions
Sponsor study identifier
interventional
8
1 country
2
Study Start
November 9, 2020
Actual (reported)Primary Completion
January 1, 2025
Actual (reported)Study Completion
February 21, 2025
Actual (reported)This study is a case-control observational study, involving persons with multiple sclerosis and healthy controls. The study contains 1 descriptive and 4 experimental sessions. In the descriptive session, participant's clinical motor and cognitive functions are collected. In the first experimental session, participant's beat perception and synchronisation abilities is examined within a finger tapping paradigm. In the following experimental sessions participants synchronsiation abilities is examined during walking paradigms, to music and metronomes, at different tempi and alignment strategies. In the latter three sessions, apart from outcome measures of synchronization the following will be collected as well: spatio-temporal gait parameters, perceived fatigue, perceived motivation and perceived speed of walking.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 21, 2025
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 9, 2020
Actual (reported)November 9, 2020
Actual (reported)November 20, 2020
Actual (reported)January 1, 2025
Actual (reported)February 21, 2025
Actual (reported)Resultant Vector Length
synchronisation consistency
week 3
Resultant Vector Length
synchronisation consistency
week 4
Resultant Vector Length
synchronisation consistency
week 5
Relative phase angle
asynchrony in time to quantify synchronization accuracy (in degrees and in milliseconds respectively)
week 3
Relative phase angle
asynchrony in time to quantify synchronization accuracy (in degrees and in milliseconds respectively)
week 4
Relative phase angle
asynchrony in time to quantify synchronization accuracy (in degrees and in milliseconds respectively)
Cadence
week 3
Cadence
week 4
Cadence
week 5
Stride length
week 3
Stride length
week 4
The study contains 1 descriptive and 4 experimental sessions. In the descriptive session, participant's clinical motor and cognitive functions are collected. In the first experimental session, participant's beat perception and synchronisation abilities is examined within a finger tapping paradigm. In the following experimental sessions participants synchronsiation abilities is examined during walking paradigms, to music and metronomes, at different tempi and alignment strategies. In the latter three sessions, apart from outcome measures of synchronization the following will be collected as well: spatio-temporal gait parameters, perceived fatigue, perceived motivation and perceived speed of walking.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
National MS Center Melsbroek
Melsbroek, Belgium
Noorderhart Revalidatie & MS centrum
Overpelt, 3900, Belgium
Baliviera E, Rosso M, Moens B, Poncelet M, Manto M, Cabaraux P, Van Wijmeersch B, Leman M, Feys P, Moumdjian L. Neural and behavioral entrainment to auditory rhythmic perturbations in persons with cerebellar impairment. Cereb Cortex. 2025 Jul 1;35(7):bhaf164. doi: 10.1093/cercor/bhaf164.
Peter Feys, prof. dr.
Hasselt University
Lousin Moumdjian, dr.
Hasselt University
8 participants (actual enrollment reported by the registry).
First Submitted
November 9, 2020
First Posted
November 20, 2020
Study Start
November 9, 2020
Actual (reported)The Impact of Training on Sitting Time and Brain Volumes in Multiple Sclerosis.
week 5
Perceptual tempo and rhythm judgements
subjective indications in regards to what the participants hear in terms
week 2
Asynchrony
timing difference between the tap and the beat
week2
EEG
64 channel EEG measurement (only conducted in 4 PwMS and HC) -\> neural correlates of entrainment
week 2
Muscle weakness
Motricity Index of dorsi flexors, knee extensors and hip flexors -
week 1
Spasticity
Modified Aschowrth scale Hamstrings, Tricepts Surae, Quadricepts
week 1
Ataxia
Scale for the assessment and rating of ataxia
week 1
Dynamic gait index
dynamic balance
week 1
Time up and Go test
balance
week 1
6 minute walking test
gait pattern and endurance
week 1
Brief repeatable battery of Rao
cognitive test
week 1
Symbol digit mobility test
cognitive test
week 1
Stroop test 0
cognitive test
week 1
MS walking scale -12
impact of MS on walking ability
week 1
Activities-specific balance confidence scale
rating of balance confidence in performing activities of daily life
week 1
Modified fatigue impact scale
effect of fatigue
week 1
Hospital Anxiety and Depression Scale
determine the levels of anxiety and depression
week 1
Dual task questionnaire
troubles a person have when performing a dual task during daily activity
week 1
Contact the study team to confirm eligibility.
Primary Completion
January 1, 2025
Actual (reported)Study Completion
February 21, 2025
Actual (reported)Last Updated
February 27, 2025
Record last verified: 2024-04
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Source: ClinicalTrials.gov.
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