NCT04637074

Brief Summary

The cerebral collateral circulation refers to the subsidiary network of vascular channels that stabilize cerebral blood flow when principal conduits fail. Collateral status differs among patients with acute ischemic stroke. Relatively sparse attention has been devoted to the role of baseline collateral circulation in patients with acute ischemic stroke who are candidates for revascularization. This study aim to investigate the correlation between baseline collateral circulation and the likelihood of opening of an arterial occlusion, the extent of reperfusion, tissue injury and clinical impairment.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
300

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Nov 2020

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 15, 2020

Completed
Same day until next milestone

Study Start

First participant enrolled

November 15, 2020

Completed
4 days until next milestone

First Posted

Study publicly available on registry

November 19, 2020

Completed
5.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 30, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2025

Completed
Last Updated

December 29, 2021

Status Verified

November 1, 2021

Enrollment Period

5.1 years

First QC Date

November 15, 2020

Last Update Submit

December 27, 2021

Conditions

Ischemic Stroke

Outcome Measures

Primary Outcomes (1)

  • Modified Rankin Scale

    Good functional outcome will be defined by a Modified Rankin Scale of 0-2, 3 months after stroke onset

    3 month

Eligibility Criteria

Age18 Years - 85 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients experiencing brain infarction complicating the large-vessel occlusion

You may qualify if:

  • Age ≥ 18 years.
  • Mechanical thrombectomy initiated within 24 hours after onset
  • CT perfusion can be performed before the initiation of thrombectomy and 24h after thrombectomy

You may not qualify if:

  • Contraindication to imaging with contrast agents
  • Delay between imaging and beginning of thrombectomy \> 90 minutes

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Neurology, First Affiliated Hospital of Fujian Medical University

Fuzhou, 350000, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

10mL venous blood sample will be collected Each participant

MeSH Terms

Conditions

Ischemic Stroke

Condition Hierarchy (Ancestors)

StrokeCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Central Study Contacts

Ying M Fu, MD

CONTACT

+8613920263688fuying@fjmu.eu.cn

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Director of Neurology department

Study Record Dates

First Submitted

November 15, 2020

First Posted

November 19, 2020

Study Start

November 15, 2020

Primary Completion

December 30, 2025

Study Completion

December 30, 2025

Last Updated

December 29, 2021

Record last verified: 2021-11

Locations

CN(1)