Correlation Between the Changes of Retinal Structure and Function and Ischemic Stroke

NCT05281887 | Recruiting

• 1 other identifier: GDREC2020207H(R1)
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Ischemic stroke is the most common type of stroke, accounting for 60%-80% of all types of strokes, and is one of the leading global causes of death and severe disability. In the risk factors of stroke, carotid atherosclerosis have higher incidence.As the only visible microvessels in vivo, retinal can provides an accurate window into cerebrovascular and systemic vascular conditions. Optical coherence tomography angiography (OCTA) and electroretinogram (ERG) can be used to quantitatively analyze the retinal structure and function in patients with ischemic stroke, and find out the valuable parameters. Electroencephalogram(EEG) can collect the electrical activity of cerebral cortex in patients with ischemic stroke and find the correlation between EEG and ERG. Finally, it is of great significance to establish a non-invasive, more objective, convenient and safe risk prediction model for stroke in combination with carotid atherosclerosis, retinal structural and functional parameters and EEG.

Conditions

Ischemic Stroke

Keywords

Ischemic Stroke; retinal

Outcome Measures

Primary Outcomes (2)

• Optical coherence tomography angiography (OCTA)

  Quantitatively analyzing the retinal microcirculation and structure in patients with ischemic stroke by using OCTA.

  1year

• Electroretinogram (ERG)

  The amplitude(μV) and implicit time(ms) of a-wave, b-wave and oscillatory potentials in dark-adapted and light-adapted.

  1year

Other Outcomes (1)

• Electroencephalogram(EEG)

  1year

Study Arms (2)

ischemic stroke

According to diagnostic criteria

healthy control

without any retinal diseases

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

ischemic stroke

You may qualify if:

• Patients with ischemic stroke

You may not qualify if:

• Refractive interstitial turbidity affect the examination results
• Any retinal diseases
• Other causes of ischemic stroke (cardiogenic embolism, dissection aneurysm, hemagglutination disorder, polycythemia, vasculitis, vascular malformation, etc.)
• Fails to complete an ophthalmic examination or the follow-up

Sponsors & Collaborators

• Guangdong Provincial People's Hospital: lead

Study Sites (1)

Guangdong Provincial People's Hospital

Guangzhou, Guangdong, 510080, China

RECRUITING

MeSH Terms

Conditions

Ischemic Stroke

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Qianli Meng

  Guangdong Provincial People's Hospital

  STUDY DIRECTOR

Central Study Contacts

Qianli Meng

CONTACT

13926469923; mengqly@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 5, 2022
• First Posted: March 16, 2022
• Study Start: December 1, 2021
• Primary Completion: December 31, 2022
• Study Completion (Estimated): January 1, 2032
• Last Updated: August 9, 2022

Record last verified: 2021-12

Locations

CN (1)