LUS in Acute Heart Failure Therapeutic Adaptation

NCT04633629 | Unknown

• 2 other identifiers: 38RC20.3282020-A02413-36
• Study Type: observational
• Target: 94
• Locations: 0 countries
• Sites: N/A

Brief Summary

Evaluate lung ultrasound aspect according to diuretics dosage evolution in patients hospitalized for acute heart failure.

Conditions

Acute Heart Failure; Pulmonary Congestion

Keywords

Lung Ultrasound; Diuretics; Medical department

Outcome Measures

Primary Outcomes (1)

• Lung ultrasound aspect according to diuretics dosage evolution.

  B-lines number on LUS

  LUS will be performed daily during the whole hospitalisation length (on average 7 days).

Secondary Outcomes (5)

• Lung ultrasound aspect according to clinical signs of acute heart failure (crackling auscultation or lower limbs edema)

  LUS and clinical examination will be performed daily during the whole hospitalisation length (on average 7 days).

• Lung ultrasound aspect according to acute kidney injury (based on plasmatic creatinine levels).

  LUS will be performed daily during the whole hospitalisation length (on average 7 days). Plasmatic creatinine measure will be performed at least weekly.

• Lung ultrasound aspect according to early prognosis (re-hospitalisation or mortality within 30 days after discharge)

  LUS will be performed daily during the whole hospitalisation length (on average 7 days). Patient will be called 30 days after discharge.

• Feasibility of daily LUS in medical department.

  LUS will be performed daily during the whole hospitalisation length (on average 7 days).

• Interest of LUS compared to clinical examination at discharge.

  LUS and clinical examination will be performed daily during the whole hospitalisation length (on average 7 days).

Study Arms (1)

Patients with acute heart failure

Patients hospitalized for acute heart failure in medical department.

Other: Lung ultrasound

Interventions

Lung ultrasound OTHER

We will perform daily a lung ultrasound to evaluate pulmonary congestion by counting B-lines.

Patients with acute heart failure

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged over 18, hospitalized from the emergency department in the medical department for acute heart failure.

You may qualify if:

• Acute heart failure diagnosed by a senior physician in the medical department, with a confirmation of a second senior physician.
• Hospitalised in the medical department.
• No objection from the patient of his trusted person.

You may not qualify if:

• Administrative supervision or deprived of their liberty
• Pulmonary conditions distracting lung ultrasound (pneumonectomy, pulmonary fibrosis)
• Chronically dialysed

Sponsors & Collaborators

• University Hospital, Grenoble: lead

Related Publications (6)

• Ohman J, Harjola VP, Karjalainen P, Lassus J. Focused echocardiography and lung ultrasound protocol for guiding treatment in acute heart failure. ESC Heart Fail. 2018 Feb;5(1):120-128. doi: 10.1002/ehf2.12208. Epub 2017 Sep 28.

  PMID: 28960894 BACKGROUND

• Coiro S, Rossignol P, Ambrosio G, Carluccio E, Alunni G, Murrone A, Tritto I, Zannad F, Girerd N. Prognostic value of residual pulmonary congestion at discharge assessed by lung ultrasound imaging in heart failure. Eur J Heart Fail. 2015 Nov;17(11):1172-81. doi: 10.1002/ejhf.344. Epub 2015 Sep 29.

  PMID: 26417699 BACKGROUND

• Gargani L, Pang PS, Frassi F, Miglioranza MH, Dini FL, Landi P, Picano E. Persistent pulmonary congestion before discharge predicts rehospitalization in heart failure: a lung ultrasound study. Cardiovasc Ultrasound. 2015 Sep 4;13:40. doi: 10.1186/s12947-015-0033-4.

  PMID: 26337295 BACKGROUND

• Platz E, Merz AA, Jhund PS, Vazir A, Campbell R, McMurray JJ. Dynamic changes and prognostic value of pulmonary congestion by lung ultrasound in acute and chronic heart failure: a systematic review. Eur J Heart Fail. 2017 Sep;19(9):1154-1163. doi: 10.1002/ejhf.839. Epub 2017 May 30.

  PMID: 28557302 BACKGROUND

• Volpicelli G, Caramello V, Cardinale L, Mussa A, Bar F, Frascisco MF. Bedside ultrasound of the lung for the monitoring of acute decompensated heart failure. Am J Emerg Med. 2008 Jun;26(5):585-91. doi: 10.1016/j.ajem.2007.09.014.

  PMID: 18534289 BACKGROUND

• Rusu DM, Siriopol I, Grigoras I, Blaj M, Ciumanghel AI, Siriopol D, Nistor I, Onofriescu M, Sandu G, Cobzaru B, Scripcariu DV, Diaconu O, Covic AC. Lung Ultrasound Guided Fluid Management Protocol for the Critically Ill Patient: study protocol for a multi-centre randomized controlled trial. Trials. 2019 Apr 25;20(1):236. doi: 10.1186/s13063-019-3345-0.

  PMID: 31023358 BACKGROUND

Study Officials

• Perrine Dumanoir, Doctor

  University Hospital, Grenoble

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Perrine Dumanoir, Doctor

CONTACT

+33476767098; pdumanoir@chu-grenoble.fr

Mélanie Arnaud

CONTACT

+3376767098; marnaud3@chu-grenoble.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 8, 2020
• First Posted: November 18, 2020
• Study Start: December 1, 2020
• Primary Completion: May 1, 2021
• Study Completion: October 1, 2021
• Last Updated: November 18, 2020

Record last verified: 2020-11