NCT04628442|CompletedDMC
Tissue Immune Interaction in Nasal Polyposis
TIP
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TIP
Sponsor study identifier
Secondary identifiers
observational
38
1 country
1
Study Start
November 10, 2020
Actual (reported)Primary Completion
March 24, 2023
Actual (reported)Study Completion
March 24, 2023
Actual (reported)This is a cross-sectional study of up to 100 subjects who are undergoing clinically indicated sinus procedures to treat chronic rhinosinusitis. Participants will be asked to donate leftover sino-nasal secretions, sino-nasal tissue and blood as well as undergo partial characterization. As optional extensions of the main study, participants may also undergo a biopsy of extra sino-nasal tissue for additional tissue analysis and/or a more detailed characterization visit performed in the UCSF Airway Center Research Center (ACRC).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 24, 2023
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 27, 2020
Actual (reported)November 10, 2020
Actual (reported)November 13, 2020
Actual (reported)March 24, 2023
Actual (reported)March 24, 2023
Actual (reported)Percentage of ILC2 and tuft cells
This study enrolls chronic rhinosinusitis patients with and without nasal polyps. Investigators aim to compare the percentage of ILC2 and tuft cells present in nasal tissue and secretions between those who present with nasal polyps and without nasal polyps.
Up to 8 hours
Those in TIP-OB will be undergoing regularly scheduled office-based procedures at the otolaryngology clinic at UCSF Mount Zion campus. The investigators will be collecting nasal mucus and blood samples during each of their visits to the clinic, up to 9 times.
Those in TIP-OR will be undergoing regularly scheduled surgeries in the operating room at UCSF Parnassus or Mount Zion campus. The investigators will be collected nasal polyp tissue, nasal mucus if possible, and blood samples during each of their surgeries, up to 9 times. The investigators will also collect inferior turbinate tissue if consented to.
This is a medical procedure prescribed by the participant's physician that has been deemed necessary for patient care in order to address their chronic rhinosinusitis.
This is a surgical procedure prescribed by the participant's physician that has been deemed necessary for patient care in order to address their chronic rhinosinusitis.
Participants with chronic rhinosinusitis who present with or without nasal polyps between the ages of 18 and 80 years.
UCSF Airway Clinical Research Center
San Francisco, California, 94143, United States
Nasal polyp tissue collected from the nasal passages, inferior turbinate tissue collected form the nasal passages, mucus collected from the nasal passages, induced sputum, and blood.
John Fahy, MD, MSc
University of California, San Francisco
38 participants (actual enrollment reported by the registry).
First Submitted
February 27, 2020
First Posted
November 13, 2020
Study Start
November 10, 2020
Actual (reported)Biomarkers of Response to Mepolizumab Treatment in Patients With Nasal Polyps With or Without Bronchial Asthma
A biopsy is optional and will remove a sample of inferior turbinate tissue from the nasal passage. It will be performed during a nasal polyp removal surgery already scheduled for patient care.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Primary Completion
March 24, 2023
Actual (reported)Study Completion
March 24, 2023
Actual (reported)Last Updated
July 30, 2025
Record last verified: 2025-07
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Source: ClinicalTrials.gov.
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