The Effect of Arterial Oxygen Parameters on Antioxidant Parameters

NCT04627220 | Completed

• 1 other identifier: Bursa High Education Hospital
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

We aimed to measure the changes in your blood values caused by different but safe oxygen values used by us during your heart surgery under laboratory conditions.

Conditions

Cardiovascular Diseases

Keywords

cardiovascular surgery; antioxidant; tiyol-disülfid homeostasis; ischemia modified albumin

Outcome Measures

Primary Outcomes (1)

• assessment of oxidative damage

  To measure the degree of oxidative damage in the patient's blood at different oxygen values used in cardiac bypass surgeries with thiol disulfide homeostasis and ischemia-modified albumin at times determined.

  48 hours after operation

Study Arms (2)

group 1

Group 1: Pressure of arterial oxygen\> 200 mmHg during the coronary surgery

Diagnostic Test: taken venous sample

group 2

Group 2: Pressure of arterial oxygen\<200 mmHg and \>80 mmHg during the coronary surgery

Diagnostic Test: taken venous sample

Interventions

taken venous sample DIAGNOSTIC_TEST

Venous blood samples taken during the operation and at the 48th hour after the operation will be examined after appropriate procedures.

group 1; group 2

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

128 patients scheduled for cardiac surgery

You may qualify if:

• patient scheduled for cardiac surgery
• ASA\>3
• Aged 18-75 years

You may not qualify if:

• those with valvular disease
• EF\<%40
• BMI\>40 kg/m2
• presence of arrhythmia that impairs hemodynamics
• previous history of cerebrovascular
• diagnosed with end-stage organ failure

Sponsors & Collaborators

• Bursa Yuksek Ihtisas Training and Research Hospital: lead

Study Sites (1)

University of Health Sciences Bursa Yüksek İhtisas Training and Research Hospital

Bursa, 60160, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Cardiovascular Diseases

Study Officials

• Ümran K Karaca, md

  Bursa Yuksek Ihtisas Training and Research Hospital

  PRINCIPAL INVESTIGATOR

• Tuğba O Onur, MD

  Bursa Yuksek Ihtisas Training and Research Hospital

  STUDY DIRECTOR

• Şeyda Ö Özgünay, MD

  Bursa Yuksek Ihtisas Training and Research Hospital

  STUDY DIRECTOR

• Filiz A Ata, MD

  Bursa Yuksek Ihtisas Training and Research Hospital

  STUDY DIRECTOR

• Canan Y Yılmaz, MD

  Bursa Yuksek Ihtisas Training and Research Hospital

  STUDY DIRECTOR

• Şermin E Eminoğlu, MD

  Bursa Yuksek Ihtisas Training and Research Hospital

  STUDY DIRECTOR

• Halil Erkan S Sayan, MD

  Bursa Yuksek Ihtisas Training and Research Hospital

  STUDY DIRECTOR

• Yasemin Ü Üstündağ, MD

  Bursa Yuksek Ihtisas Training and Research Hospital

  STUDY DIRECTOR

• Anıl O Onur, MD

  Bursa Yuksek Ihtisas Training and Research Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Days
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: November 3, 2020
• First Posted: November 13, 2020
• Study Start: January 1, 2020
• Primary Completion: October 1, 2020
• Study Completion: November 1, 2020
• Last Updated: November 13, 2020

Record last verified: 2020-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)